Investigation of prognostic indicators for human uveal melanoma as biomarkers of canine uveal melanoma metastasis

2013 ◽  
Vol 54 (11) ◽  
pp. 584-593 ◽  
Author(s):  
P. Malho ◽  
K. Dunn ◽  
D. Donaldson ◽  
R. R. Dubielzig ◽  
Z. Birand ◽  
...  
Keyword(s):  
Uveal Melanoma ◽  
Prognostic Indicators ◽  
Melanoma Metastasis

scholarly journals Digital Image Analysis of BAP-1 Accurately Predicts Uveal Melanoma Metastasis

2019 ◽  
Vol 8 (3) ◽  
pp. 11 ◽  
Author(s):  
Gustav Stålhammar ◽  
Thonnie Rose O. See ◽  
Stephen Phillips ◽  
Stefan Seregard ◽  
Hans E. Grossniklaus
Keyword(s):  
Image Analysis ◽  
Uveal Melanoma ◽  
Digital Image ◽  
Digital Image Analysis ◽  
Melanoma Metastasis

scholarly journals Immunoexpression of Macroh2a in Uveal Melanoma

2019 ◽  
Vol 9 (16) ◽  
pp. 3244 ◽  
Author(s):  
Salvatorelli ◽  
Puzzo ◽  
Bartoloni ◽  
Palmucci ◽  
Longo ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Uveal Melanoma ◽  
Metastatic Disease ◽  
Cutaneous Melanoma ◽  
High Expression ◽  
Melanoma Metastasis ◽  
Proper Treatment ◽  
Immunohistochemical Expression ◽  
Prognostic Role

MacroH2A is a histone variant whose expression has been studied in several neoplasms, including cutaneous melanomas (CMs). In the literature, it has been demonstrated that macroH2A.1 levels gradually decrease during CM progression, and a high expression of macroH2A.1 in CM cells relates to a better prognosis. Although both uveal and cutaneous melanomas arise from melanocytes, uveal melanoma (UM) is biologically and genetically distinct from the more common cutaneous melanoma. Metastasis to the liver is a frequent occurrence in UM, and about 40%–50% of patients die of metastatic disease, even with early diagnosis, proper treatment, and close follow-up. We wanted to investigate macroH2A.1 immunohistochemical expression in UM. Our results demonstrated that mH2A.1 expression was higher in metastatic UM (21/23, 91.4%), while only 18/32 (56.3%). UMs without metastases showed mH2A.1 staining. These data could suggest a possible prognostic role for mH2A.1 and could form a basis for developing new pharmacological strategies for UM treatment.

Genome-Wide Analysis of Uveal Melanoma Metastasis-Associated LncRNAs and Their Functional Network

2018 ◽  
Vol 37 (2) ◽  
pp. 99-108 ◽  
Author(s):  
Binbin Xu ◽  
Ruiqi Ma ◽  
Hui Ren ◽  
Jiang Qian
Keyword(s):  
Uveal Melanoma ◽  
Functional Network ◽  
Melanoma Metastasis ◽  
Genome Wide Analysis ◽  
Genome Wide

The left ventricle as the first site of uveal melanoma metastasis 13 years after treatment of the primary tumor

2011 ◽  
Vol 21 (2) ◽  
pp. 160-163 ◽  
Author(s):  
Nathalie A. Kolandjian ◽  
Sapna P. Patel ◽  
Nicholas E. Papadopoulos ◽  
Agop Y. Bedikian
Keyword(s):  
Left Ventricle ◽  
Uveal Melanoma ◽  
Primary Tumor ◽  
Melanoma Metastasis

scholarly journals BAP1 methylation: a prognostic marker of uveal melanoma metastasis

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Mathieu F. Bakhoum ◽  
Ellis J. Curtis ◽  
Michael H. Goldbaum ◽  
Paul S. Mischel
Keyword(s):  
High Risk ◽  
Dna Sequencing ◽  
Prognostic Marker ◽  
Uveal Melanoma ◽  
Primary Tumor ◽  
Melanoma Metastasis ◽  
Primary Cancer ◽  
Melanoma Patients

AbstractUveal melanoma, the most common intraocular primary cancer in adults, is characterized by striking variability in metastatic tendencies. BAP1 deletion in the primary tumor is associated with uveal melanoma metastasis, but it cannot always be resolved by bulk DNA sequencing of heterogeneous tumors. Here, we show that assessment of BAP1 methylation is an accurate and readily clinically actionable assay to accurately identify high-risk uveal melanoma patients.

scholarly journals Interpreting Discordant Monosomy 3 FISH and Chromosomal Microarray Analysis Results in Uveal Melanoma

2020 ◽  
Author(s):  
Nicholas Coley ◽  
Christopher Long ◽  
Simrin Sennik ◽  
John Thorson ◽  
Jonathan Lin
Keyword(s):  
Microarray Analysis ◽  
Uveal Melanoma ◽  
Molecular Pathology ◽  
Limit Of Detection ◽  
Prognostic Indicators ◽  
Chromosomal Microarray ◽  
Chromosomal Microarray Analysis ◽  
First Case ◽  
Monosomy 3 ◽  
Single Positive

Abstract Background: Uveal melanoma is the most common primary ocular tumor in adults and causes morbidity through lymphovascular metastasis. The presence of monosomy 3 in uveal melanomas is one of the most important prognostic indicators for metastasis. Two major molecular pathology testing modalities to assess monosomy 3 are fluorescent in situ hybridization (FISH) and chromosomal microarray analysis (CMA). Here, we report two cases of discordant monosomy 3 test results in uveal melanoma enucleation specimens using these molecular pathology tests.Case presentation: The first case is a uveal melanoma from a 51-year-old male that showed no evidence of monosomy 3 by CMA, but was subsequently detected by FISH. The second case is a uveal melanoma from a 49-year-old male that showed monosomy 3 at the limit of detection by CMA that was not detected by subsequent FISH.Conclusions: These two cases underscore the differences of each testing modality for monosomy 3. The high percentage of cells with one chromosome 3 signal requisite for a positive monosomy 3 FISH result may not be sensitive enough to detect a low level of monosomy 3 that CMA can detect. Conversely, a small uveal melanoma with monosomy 3 may be missed by CMA owing to background DNA from cytologically normal retina and other ocular tissues. Our cases suggest that both testing methods should be pursued for uveal melanoma, with a single positive result for either test interpreted as presence of monosomy 3.

scholarly journals Uveal Melanoma Metastasis Models

2015 ◽  
Vol 1 (3) ◽  
pp. 151-160 ◽  
Author(s):  
Hua Yang ◽  
Jinfeng Cao ◽  
Hans E. Grossniklaus
Keyword(s):  
Uveal Melanoma ◽  
Melanoma Metastasis ◽  
Metastasis Models

Blood biomarkers of uveal melanoma metastasis

2010 ◽  
Vol 95 (1) ◽  
pp. 3-4 ◽  
Author(s):  
P. L. Triozzi ◽  
A. D. Singh
Keyword(s):  
Uveal Melanoma ◽  
Melanoma Metastasis ◽  
Blood Biomarkers
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