The left ventricle as the first site of uveal melanoma metastasis 13 years after treatment of the primary tumor

2011 ◽  
Vol 21 (2) ◽  
pp. 160-163 ◽  
Author(s):  
Nathalie A. Kolandjian ◽  
Sapna P. Patel ◽  
Nicholas E. Papadopoulos ◽  
Agop Y. Bedikian
Keyword(s):  
Left Ventricle ◽  
Uveal Melanoma ◽  
Primary Tumor ◽  
Melanoma Metastasis

scholarly journals BAP1 methylation: a prognostic marker of uveal melanoma metastasis

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Mathieu F. Bakhoum ◽  
Ellis J. Curtis ◽  
Michael H. Goldbaum ◽  
Paul S. Mischel
Keyword(s):  
High Risk ◽  
Dna Sequencing ◽  
Prognostic Marker ◽  
Uveal Melanoma ◽  
Primary Tumor ◽  
Melanoma Metastasis ◽  
Primary Cancer ◽  
Melanoma Patients

AbstractUveal melanoma, the most common intraocular primary cancer in adults, is characterized by striking variability in metastatic tendencies. BAP1 deletion in the primary tumor is associated with uveal melanoma metastasis, but it cannot always be resolved by bulk DNA sequencing of heterogeneous tumors. Here, we show that assessment of BAP1 methylation is an accurate and readily clinically actionable assay to accurately identify high-risk uveal melanoma patients.

scholarly journals Digital Image Analysis of BAP-1 Accurately Predicts Uveal Melanoma Metastasis

2019 ◽  
Vol 8 (3) ◽  
pp. 11 ◽  
Author(s):  
Gustav Stålhammar ◽  
Thonnie Rose O. See ◽  
Stephen Phillips ◽  
Stefan Seregard ◽  
Hans E. Grossniklaus
Keyword(s):  
Image Analysis ◽  
Uveal Melanoma ◽  
Digital Image ◽  
Digital Image Analysis ◽  
Melanoma Metastasis

Investigation of prognostic indicators for human uveal melanoma as biomarkers of canine uveal melanoma metastasis

2013 ◽  
Vol 54 (11) ◽  
pp. 584-593 ◽  
Author(s):  
P. Malho ◽  
K. Dunn ◽  
D. Donaldson ◽  
R. R. Dubielzig ◽  
Z. Birand ◽  
...  
Keyword(s):  
Uveal Melanoma ◽  
Prognostic Indicators ◽  
Melanoma Metastasis

scholarly journals Immunoexpression of Macroh2a in Uveal Melanoma

2019 ◽  
Vol 9 (16) ◽  
pp. 3244 ◽  
Author(s):  
Salvatorelli ◽  
Puzzo ◽  
Bartoloni ◽  
Palmucci ◽  
Longo ◽  
...  
Keyword(s):  
Early Diagnosis ◽  
Uveal Melanoma ◽  
Metastatic Disease ◽  
Cutaneous Melanoma ◽  
High Expression ◽  
Melanoma Metastasis ◽  
Proper Treatment ◽  
Immunohistochemical Expression ◽  
Prognostic Role

MacroH2A is a histone variant whose expression has been studied in several neoplasms, including cutaneous melanomas (CMs). In the literature, it has been demonstrated that macroH2A.1 levels gradually decrease during CM progression, and a high expression of macroH2A.1 in CM cells relates to a better prognosis. Although both uveal and cutaneous melanomas arise from melanocytes, uveal melanoma (UM) is biologically and genetically distinct from the more common cutaneous melanoma. Metastasis to the liver is a frequent occurrence in UM, and about 40%–50% of patients die of metastatic disease, even with early diagnosis, proper treatment, and close follow-up. We wanted to investigate macroH2A.1 immunohistochemical expression in UM. Our results demonstrated that mH2A.1 expression was higher in metastatic UM (21/23, 91.4%), while only 18/32 (56.3%). UMs without metastases showed mH2A.1 staining. These data could suggest a possible prognostic role for mH2A.1 and could form a basis for developing new pharmacological strategies for UM treatment.

Genome-Wide Analysis of Uveal Melanoma Metastasis-Associated LncRNAs and Their Functional Network

2018 ◽  
Vol 37 (2) ◽  
pp. 99-108 ◽  
Author(s):  
Binbin Xu ◽  
Ruiqi Ma ◽  
Hui Ren ◽  
Jiang Qian
Keyword(s):  
Uveal Melanoma ◽  
Functional Network ◽  
Melanoma Metastasis ◽  
Genome Wide Analysis ◽  
Genome Wide

scholarly journals Presumed Melanoma of Unknown Primary Origin Metastatic to the Choroid Mimics Primary Uveal Melanoma

2021 ◽  
pp. 987-993
Author(s):  
John M. Rieth ◽  
Randy Chris Bowen ◽  
Mohammed M. Milhem ◽  
H. Culver Boldt ◽  
Elaine M. Binkley
Keyword(s):  
Genetic Analysis ◽  
Uveal Melanoma ◽  
Primary Tumor ◽  
Tumor Tissue ◽  
Treatment Options ◽  
Unknown Primary ◽  
Primary Malignancy ◽  
Rare Presentation ◽  
Primary Origin ◽  
Unknown Primary Origin

We describe the case of a 69-year-old woman who presented with a decline in vision in the left eye and was found to have a choroidal lesion with clinical and echographic features concerning for primary uveal melanoma. Systemic imaging identified numerous metastases to the liver, kidneys, paratracheal lymph nodes, lung, and brain. The hepatic lesion was biopsied, and genetic analysis identified a Val600Glu (c.1799T&#x3e;A) <i>BRAF</i> mutation, consistent with a cutaneous primary malignancy, although no primary tumor was identified. This case highlights that metastasis to the choroid is a rare presentation of nonuveal melanoma that can mimic primary uveal melanoma. Genetic analysis of tumor tissue can identify the origin of the melanoma and guide treatment options. Systemic imaging should be performed prior to intervention for choroidal neoplasms.

scholarly journals Uveal Melanoma Metastasis Models

2015 ◽  
Vol 1 (3) ◽  
pp. 151-160 ◽  
Author(s):  
Hua Yang ◽  
Jinfeng Cao ◽  
Hans E. Grossniklaus
Keyword(s):  
Uveal Melanoma ◽  
Melanoma Metastasis ◽  
Metastasis Models

Blood biomarkers of uveal melanoma metastasis

2010 ◽  
Vol 95 (1) ◽  
pp. 3-4 ◽  
Author(s):  
P. L. Triozzi ◽  
A. D. Singh
Keyword(s):  
Uveal Melanoma ◽  
Melanoma Metastasis ◽  
Blood Biomarkers

scholarly journals Prognostic Value of Autophagy-related Genes Correlated With Metastasis in Uveal Melanoma Patients

2021 ◽  
Author(s):  
Yan Sun ◽  
Xiaoran Wang ◽  
Baoxin Chen ◽  
Lang Xiong ◽  
Jingqi Huang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Survival Analysis ◽  
Uveal Melanoma ◽  
Risk Score ◽  
Protein Interactions ◽  
Cox Regression ◽  
Early Stage ◽  
Expression Profiles ◽  
High Expression ◽  
Melanoma Metastasis

Abstract Half of the patients with primary uveal melanoma will develop progressive metastasis, leading to high mortality rate. Autophagy has been demonstrated to engage in metastasis in multiple tumors. Detection, diagnosis and treatment at the early-stage of uveal melanoma may help prevent potential tumor progression and optimize the prognosis. The purpose of our study was to discover autophagy-related genes (ARGs) correlated with uveal melanoma metastasis and determine their prognostic values. We analyzed the gene expression profiles and the clinical data from the Gene Expression Omnibus (GEO) database in uveal melanoma. A total of 14 and 16 differentially expressed ARGs were identified to be related to uveal melanoma metastasis from GSE22138 and GSE27831 sets. The two datasets shared three common genes including RAF1, CDKN1A and WIPI1 that occupied the core positions in the Protein-Protein Interactions (PPI) Network of ARGs. Following that, TCGA was introduced for survival analysis of the three genes. The survival analysis showed that high expression of RAF1 was related to favorable prognosis of uveal melanoma, whereas high expression of CDKN1A and WIPI1 suggested poor prognosis. Then a three-ARG based prognostic risk score model was constructed to predict survival outcomes. Univariate and multivariate Cox regression analyses indicated that the risk score can be considered as an independent prognostic factor for uveal melanoma, exhibiting good accuracy and sensitivity. In summary, we established an autophagy-related prognostic model based on uveal melanoma metastasis, which may contribute to the detection of early metastasis and prediction of prognosis, thereby prolonging survival through early personalized intervention.

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