Prospective randomised blinded clinical trial assessing effectiveness of three dental plaque control methods in dogs

IntroductionPlaque control plays a critical role in the prevention and treatment of periodontitis. Antibacterial mouthwash is one of the most important tools for plaque control. Pudilan, including extracts of Scutellaria baicalensis root, Taraxacum mongolicum, Bunge corydalis herb and Isatis indigotica, was reported playing the role of anti-inflammatory and anti-bacterial. However, its effect on dental plaque and periodontal inflammation remains unknown. We aimed to assess the efficacy of Pudilan Keyanning antibacterial mouthwash which contains the active essence of Pudilan and 0.03%–0.06% cetylpyridinium chloride, as well as Pudilan active essence for plaque control and gingival anti-inflammation in patients during periodontal maintenance phase.Methods and analysisIn this double-blind, randomised, placebo-controlled clinical trial, a total of 120 participants during periodontal maintenance phase will be enrolled. After supragingival scaling, they will be randomly assigned into three groups in a 1:1:1 ratio: the Pudilan Keyanning antibacterial mouthwash group, a chlorhexidine acetate mouthwash (0.12%) group or a placebo group with mouthwash containing the same components as the Pudilan Keyanning mouthwash except for Pudilan active ingredients. They will rinse with mouthwash, respectively, two times per day for 6 weeks. Clinical parameters (such as plaque index, bleeding index) and the level of volatile sulfide in the breath will be measured and analysed. The subgingival plaque will be collected and analysed microbiologically. Questionnaire feedback will be analysed.Ethics and disseminationThe study protocol (V.4) was reviewed and approved by the Medical Ethical Committee of Peking University School and Hospital of Stomatology (Ethics Approval No. PKUSSIRB-201950153b). All participants signed a written consent form.Trial registration numberChiCTR2000041253.

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Adjunctive Effect of Green Tea Mouthwash Prepared at Different Steeping Temperatures on Gingivitis: A Triple-Blind Randomized Controlled Clinical Trial

Dentistry Journal ◽

10.3390/dj9120139 ◽

2021 ◽

Vol 9 (12) ◽

pp. 139

Author(s):

Hani T. Fadel ◽

Alhanouf M. AlRehaili ◽

Mona M. AlShanqiti ◽

Afnan A. Alraddadi ◽

Alhanouf M. Albolowi

Keyword(s):

Clinical Trial ◽

Green Tea ◽

Dental Plaque ◽

Hot Water ◽

Controlled Clinical Trial ◽

Randomized Controlled Clinical Trial ◽

Randomized Controlled ◽

Gingival Bleeding ◽

Plaque Control ◽

The Mean

Purpose: To compare the effect of green tea mouthwashes prepared at different steeping temperatures as adjuncts to mechanical plaque control on gingivitis. Methods: Forty-five women with gingivitis participated in this 4-week randomized controlled clinical trial. They received professional mechanical plaque control and rinsed daily with either warm green tea, hot–cold green tea or placebo. Dental plaque control record (PCR) and gingival bleeding indices (GBI) were recorded at baseline and 7, 14 and 28 days after. Results: Participants’ mean age was 20.7 ± 2 years. The mean scores for the PCR and GBI at baseline were 82.4 ± 19 and 85.8 ± 7, respectively. All groups showed significant reduction in PCR and GBI between Days 0 and 28 (p < 0.01). No significant differences in PCR were observed between the groups at any of the examinations (p > 0.01). The warm green tea group demonstrated significantly lower GBI at all examinations compared to the hot–cold group (p < 0.01). Conclusions: Within study limits, green tea-made mouthwashes significantly reduced plaque and gingivitis when used as adjuncts to mechanical plaque control. The green tea mouthwash prepared in warm water demonstrated significantly higher efficacy in lowering gingivitis compared to that prepared in hot water followed by ice.

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Does Customized Handle Toothbrush Influence Dental Plaque Removal in Children with Down Syndrome? A Randomized Controlled Trial

Healthcare ◽

10.3390/healthcare9091130 ◽

2021 ◽

Vol 9 (9) ◽

pp. 1130

Author(s):

Line Droubi ◽

Mohannad Laflouf ◽

Saleh Alkurdi ◽

Salvatore Sauro ◽

Davide Mancino ◽

...

Keyword(s):

Clinical Trial ◽

Down Syndrome ◽

Special Needs ◽

Dental Plaque ◽

Controlled Trial ◽

Gingival Index ◽

Children With Down Syndrome ◽

Plaque Removal ◽

Randomized Controlled ◽

Plaque Control

The present study aimed to evaluate the effectiveness of customized handle toothbrush in dental plaque removal in children with Down syndrome in comparison to children with no special needs. A randomized clinical trial was performed on 48 children aged 6–9 years old. Participants were divided into two groups (n = 24, children with no special needs or with Down syndrome). Each group was divided into two subgroups (customized and conventional toothbrush). Plaque accumulation was evaluated using Turesky modification of the Quigley–Hein plaque index (TMQHPI) at four times (pre-brushing (T0), post-brushing at baseline (T1), 1 week (T2) and 3 weeks (T3)), and the modified gingival index (MGI) was used to evaluate the gingivitis at three times (T0, T2 and T3). Data were statistically analyzed. Plaque accumulation and gingivitis decreased significantly for all groups between T0 and T3 (p < 0.05). Both customized groups demonstrated significant lower plaque accumulation compared to conventional groups (p < 0.05) at T1, T2 and T3 and significant lower gingivitis at T3. Customizing the toothbrush handle improved child’s ability for plaque control, especially in children with Down syndrome.

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Comparative evaluation of multiflower honey, jamun honey and chlorhexidine gluconate gel (0.2%) on clinical levels of dental plaque: one week Randomized controlled clinical trial.

International Journal of Pharma and Bio Sciences ◽

10.22376/ijpbs.2017.8.4.p55-60 ◽

2017 ◽

Vol 8 (4) ◽

Author(s):

GAUTAMI S PENMETSA ◽

L KALYANI KONDEPUDI

Keyword(s):

Clinical Trial ◽

Dental Plaque ◽

Comparative Evaluation ◽

Chlorhexidine Gluconate ◽

Controlled Clinical Trial ◽

Randomized Controlled Clinical Trial ◽

Randomized Controlled

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Monitoring the efficacy of plaque control methods

Periodontology 2000 ◽

10.1111/j.1600-0757.1995.tb00043.x ◽

1995 ◽

Vol 8 (1) ◽

pp. 24-41 ◽

Cited By ~ 2

Author(s):

Frank A. Scannapieco

Keyword(s):

Control Methods ◽

Plaque Control

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Dental plaque control strategies for the elderly population: a scoping review

International Journal of Dental Hygiene ◽

10.1111/idh.12497 ◽

2021 ◽

Author(s):

María del Rosario Ruiz Núñez ◽

Mariane da Luz Raulino ◽

Renata Goulart Castro ◽

Ana Lúcia Schaefer Ferreira de Mello

Keyword(s):

Scoping Review ◽

Dental Plaque ◽

Elderly Population ◽

Control Strategies ◽

The Elderly ◽

Plaque Control

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Effect of a 0.5% chlorhexidine gel on dental plaque superinfecting microorganisms in mentally handicapped patients

Pesquisa Odontológica Brasileira ◽

10.1590/s1517-74912003000300006 ◽

2003 ◽

Vol 17 (3) ◽

pp. 228-233 ◽

Cited By ~ 7

Author(s):

Cláudio Mendes Pannuti ◽

Roberto Fraga Moreira Lotufo ◽

Silvana Cai ◽

Maria da Conceição Saraiva ◽

Nívea Maria de Freitas ◽

...

Keyword(s):

Clinical Trial ◽

Placebo Group ◽

Dental Plaque ◽

Test Group ◽

Control Group ◽

Mentally Handicapped ◽

Bacterial Populations ◽

Gram Negative ◽

Supragingival Plaque ◽

Chlorhexidine Gel

A randomized clinical trial was conducted to investigate the effect of a 0.5% chlorhexidine (CHX) gel on dental plaque superinfecting microorganisms in mentally handicapped patients. Thirty inmates from the institution "Casas André Luiz" were assigned to either test group (CHX gel, n = 15) or control group (placebo gel, n = 15). The gel was administered over a period of 8 weeks. Supragingival plaque samples were collected at baseline, after gel use (8 weeks) and 16 weeks after baseline. The presence of Gram-negative Enterobacteriaceae, Staphylococcus and yeasts was evaluated. No significant growth of any superinfecting microorganism was observed in the CHX group, when compared to the placebo group. The results indicated that the 0.5% chlorhexidine gel did not produce an undesirable shift in these bacterial populations.

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