Effect of a 0.5% chlorhexidine gel on dental plaque superinfecting microorganisms in mentally handicapped patients

A randomized clinical trial was conducted to investigate the effect of a 0.5% chlorhexidine (CHX) gel on dental plaque superinfecting microorganisms in mentally handicapped patients. Thirty inmates from the institution "Casas André Luiz" were assigned to either test group (CHX gel, n = 15) or control group (placebo gel, n = 15). The gel was administered over a period of 8 weeks. Supragingival plaque samples were collected at baseline, after gel use (8 weeks) and 16 weeks after baseline. The presence of Gram-negative Enterobacteriaceae, Staphylococcus and yeasts was evaluated. No significant growth of any superinfecting microorganism was observed in the CHX group, when compared to the placebo group. The results indicated that the 0.5% chlorhexidine gel did not produce an undesirable shift in these bacterial populations.

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The effect of Topical Application of Honey Based Gel Containing Zingibar Officinale for Non Surgical Periodontal Maintenance

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i32a31725 ◽

2021 ◽

pp. 134-139

Author(s):

Sneha Puri ◽

Rashmi Bele ◽

Akhilesh Shewale ◽

Rajvir Malik

Keyword(s):

Dental Plaque ◽

Test Group ◽

Control Group ◽

Ginger Extract ◽

Natural Gel ◽

Gingival Health ◽

Periodontal Infection ◽

The Mean ◽

Periodontal Maintenance ◽

Chlorhexidine Gel

Introduction: Ginger and honey have shown to be effective against pathogens routinely encountered in periodontal infection. However, none of literature has shown antibacterial effect of ginger and honey on the levels of dental plaque when used as a gel. Aim: To compare the effect of honey with ginger extract on the dental plaque levels and gingival health. Methodology: Fifteen systemically healthy patients were randomly allocated to either the test group [G1(ginger and honey gel = 15 sites)] or the control group [G2 (Chlorhexidine gel = 15 sites]. Full mouth Gingival Index (GI) Full mouth Plaque Index (PI) were evaluated at baseline and on 7th day. Results: The mean PI at baseline was 0.23 ± 0.02 (G1) and 0.29 ± 0.01 (G2) which was increased to 0.36 ± 0.01 (G1) and 0.37 ± 0.01 (G2) on 7th day. However, mean GI at baseline was 0.30 ± 0.04 (G1) and 0.34 ± 0.02 (G2) which was increased to 0.38 ± 0.03 (G1) and 0.43 ± 0.03 (G2) on 7th day. Conclusion: The results of this study suggest that the chlorhexidine gel and Natural gel containing Honey and Zingibar officinale both are effective in controlling plaque during the periodontal maintenance period.

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Supragingival plaque removal with and without dentifrice: a randomized controlled clinical trial

Brazilian Dental Journal ◽

10.1590/s0103-64402012000300009 ◽

2012 ◽

Vol 23 (3) ◽

pp. 235-240 ◽

Cited By ~ 4

Author(s):

Fabricio B. Zanatta ◽

Raquel P. Antoniazzi ◽

Tatiana M. P. Pinto ◽

Cassiano K. Rösing

Keyword(s):

Clinical Trial ◽

Test Group ◽

Control Group ◽

Controlled Clinical Trial ◽

Separate Analysis ◽

Randomized Controlled Clinical Trial ◽

Significance Level ◽

Plaque Removal ◽

Randomized Controlled ◽

Removal Capacity

The aim of this study was to compare the efficacy of dental plaque removal by brushing with and without conventional dentifrice. Twenty-four students aged 17 to 28 years participated in this randomized controlled clinical trial. Quadrants 1-3 or 2-4 were randomly allocated to the test group (brushing without dentifrice) or control group (brushing with dentifrice). After 72 h of cessation of oral hygiene, Quigley & Hein (Turesky) plaque index was assessed before and after brushing by a calibrated and blind examiner. Overtime and intergroup comparisons were performed by Student's paired sample t-test at 5% significance level. The results showed that both groups after toothbrushing presented statistically significant reductions in plaque, with no differences between them (from 3.06 ± 0.54 to 1.27 ± 0.26 versus from 3.07 ± 0.52 to 1.31 ± 0.23). A separate analysis of the buccal and lingual aspects also showed no significant differences between groups. It may be concluded that the use of a conventional dentifrice during toothbrushing does not seem to enhance plaque removal capacity.

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Effect of vitamin D supplementation on disease activity (SLEDAI) and fatigue in Systemic Lupus Erythematosus patients with hipovitamin D: An Open Clinical Trial

Indonesian Journal of Rheumatology ◽

10.37275/ijr.v8i2.59 ◽

2018 ◽

Vol 8 (2) ◽

Author(s):

Achmad Rifa’i ◽

Handono Kalim ◽

Kusworini Kusworini ◽

Cesarius Singgih Wahono

Keyword(s):

Systemic Lupus Erythematosus ◽

Clinical Trial ◽

Vitamin D ◽

Placebo Group ◽

Disease Activity ◽

Lupus Erythematosus ◽

Vitamin D Supplementation ◽

Control Group ◽

Systemic Lupus ◽

Significant Difference

Background : Low level of vitamin D impact the disease activity and the degree of fatigue in SLE patients. This study aims to determine the effect of vitamin D supplementation on disease activity and fatigue condition in Systemic Lupus Erythematosus (SLE) patients with hipovitamin D.Methods: We performed an open clinical trial. Subjects were randomized into two different groups (supplementation or placebo) using simple random sampling. The treatment group got vitamin D3 softgel/ cholecalciferol 1200 IU/day or 30 mg/day, while the control group gotplacebo for 3 months. SLEDAI scores and FSS scores were calculated at pre and posttreatment.Results: There were 20 subjectsfor supplementation group and 19 subjects in the placebo group. From this study, before and after treatment, we found a significant difference of mean level of vitamin D in supplementation group (p=0.000), and no significant difference inpatients with placebo (p=0.427). Moreover, from the SLEDAI score analysis, observed a significant difference bothin the supplemented group (p=0.000) and the placebo group (p=0.006). FSS scores significantly different in the supplemented group (p=0.000). Incorrelation test,there was a negative correlation (r=-0763) between vitamin D level and disease activity (SLEDAI), and both showing stastistical significance between thepre supplementation (p=0.000) and post supplementation (r=-0846; p=0.000). Similarly to theFSS scores, there was a meaningfulnegative correlation (r=-0.931, p=0.000) between the level of vitamin D with FSS scores pre and post supplementation (r=-0.911; p= 0.000). Furthermore, there was a significant correlation between disease activity (SLEDAI) pre supplementation with fatigue condition pre supplementation (r=0.846; p = 0.000) and postsupplementation (r=0.913; p= 0.000).Conclusion: The supplementation of vitamin D 1200 IU per day in patients with SLE improve disease activity and degree of fatigue. Keywords: vitamin D, disease activity, fatigue, SLE

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Changes in Distribution of Dental Biofilm after Insertion of Fixed Orthodontic Appliances

Journal of Clinical Medicine ◽

10.3390/jcm10235638 ◽

2021 ◽

Vol 10 (23) ◽

pp. 5638

Author(s):

Urszula Kozak ◽

Agnieszka Lasota ◽

Renata Chałas

Keyword(s):

Oral Hygiene ◽

Dental Plaque ◽

General Health ◽

Control Group ◽

Orthodontic Appliances ◽

Fixed Appliance ◽

Dental Biofilm ◽

Supragingival Plaque ◽

Fixed Orthodontic Appliances ◽

The Impact

Good oral hygiene is an important factor in oral and general health, especially in orthodontic patients, because fixed appliances might impede effective oral hygiene and thus increase the risks of tooth decay, periodontal disease and general health complications. This study investigated the impact of fixed orthodontic appliances on the distribution of dental biofilm in teenagers. Supragingival plaque was assessed at T0, T1 and T2. The distribution of the biofilm was analyzed. Approximal Plaque Index (API) and Bonded Bracket Index (BBI) were used to measure the presence of dental plaque. After insertion of the fixed appliance, the dental plaque indices values in the orthodontically treated group were significantly higher (p < 0.05) than in the control group. Fixed orthodontic appliances caused significant changes in the distribution of the biofilm. This was characterized by the change of location of the dental plaque. In the orthodontic group, we observed an increase in the amount of the supragingival plaque on the vestibular surface of the teeth.

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Effect of a Vibration System on Pain Reduction during Injection of Dental Anesthesia in Children: A Randomized Clinical Trial

International Journal of Dentistry ◽

10.1155/2021/8896408 ◽

2021 ◽

Vol 2021 ◽

pp. 1-8

Author(s):

Muhanad AlHareky ◽

Jehan AlHumaid ◽

Sumit Bedi ◽

Maha El Tantawi ◽

Mazin AlGahtani ◽

...

Keyword(s):

Clinical Trial ◽

Test Group ◽

The United States ◽

Nerve Fibers ◽

T Test ◽

Control Group ◽

Controlled Clinical Trial ◽

Clinical Trial Registry ◽

Dental Anesthesia ◽

Gate Control Theory

Background. The ‘‘gate control’’ theory suggests pain can be reduced by simultaneous activation of larger diameter nerve fibers using appropriate coldness, warmth, rubbing, pressure, or vibration. This study investigated the efficacy of a device combining cold and vibration, for needle-related procedural pain in children. Methodology. A total of 51 children aged 5–12 years participated in this randomized controlled clinical trial. Half of the children were in the control group and received maxillary buccal infiltration, by injecting 1.8 ml of 2% lidocaine with 1 : 100,000 adrenaline using topical anesthesia 20% benzocaine gel for 15 seconds, while the other half were in the test group and received the same anesthesia using a commercially available external cold and a vibrating device. A face version of Visual Analogue Scale (VAS) was used as a subjective measure to assess the child’s pain experience. The parents were requested to evaluate the child’s ability to tolerate pain using a behavioral/observational pain scale. Sound, Eyes, and Motor (SEM) scale and Faces, Legs, Activity, Cry, and Consolability (FLACC) scale were used to record the child’s pain as perceived by the external evaluator. T-test or Mann–Whitney U-test was used for scale variables, paired sample T-test or Wilcoxon rank t-test was used for before and after data, and chi-square was used for categorical variable, based on the results of normality test. Results. The results showed a statistically significant reduction in pain after the injection for the test group compared with control using VAS scale (mean = 6.68 (1.09) and 8.42 (0.50); p = 0.001 ) and FLACC scale (mean = 5.92 (1.05) and 8.16 (0.54); p = 0.002 ), but not when using SEM scale (mean 3.22 (0.42) and 4.24 (2.74); p = 0.08 ). Conclusions. Combined external cold and vibrating devices can be an effective alternative in reducing experienced pain and fear in children undergoing infiltration dental anesthesia. This study was registered with clinical trial registry of the United States National Institutes of Health (NIH) at ClinicalTrials.gov (NCT03953001).

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The effect of reflexology on quality of life in Iranian patients with breast cancer.

Journal of Clinical Oncology ◽

10.1200/jco.2016.34.26_suppl.90 ◽

2016 ◽

Vol 34 (26_suppl) ◽

pp. 90-90

Author(s):

Shadan Pedramrazi

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Placebo Group ◽

Test Group ◽

Control Group ◽

Relaxation Techniques ◽

Control Groups ◽

Significant Difference ◽

And Control

90 Background: Breast cancer is one the most prevalent cancers among Iranian women. One of the complementary therapies is reflexology. The extant paper has been provided with the objective of determining the effect of reflexology on quality of life of patients with breast cancer undergoing chemotherapy in the breast disease center. Methods: This study is a randomized clinical trial which has been applied to 60 patients suffering from breast cancer under chemotherapy in breast diseases center, in 2012. The patients were selected randomly in three test, control and placebo groups. In test group, reflexology was implemented for 3 weeks and each session lasted half an hour. In placebo group, only relaxation techniques were implemented for 3 weeks, each session lasted 20-30 minutes. Control group received the routine therapies of breast cancer center. Results: Data were collected by standard questionnaires of EORTIC QLQ-C30.V.3 and EORTIC QLQ-BR23.V.3. The questionnaires were filled before intervention and two weeks after applying study. There was no significant difference in demographic characteristics or quality of life score of three groups, before intervention. Total score of quality of life was higher in interventional group compared to placebo group before and two weeks after intervention (p < 0.001) Results also indicated a significant difference in total score of quality of life between three test, placebo, and control groups after intervention (p < 0.001). A considerable improvement was noticed in the different aspects of quality of life in the test group compared to two other placebo and control groups. Conclusions: Reduction of pain, anxiety, nausea, and other symptoms related to cancer in patients suffering from cancer are assumed as the important cases of nursing cares focus, and precise nursing may diminish these symptoms considerably. Using reflexology in patients suffering from breast cancer may improve the quality of life as an effective method, and can be recommended for use in patients with breast cancer if it is supervised by health system personnel.

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Effects of the Preoperative Administration of Dexketoprofen Trometamol on Pain and Swelling After Implant Surgery: A Randomized, Double-Blind Controlled Trial

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-17-00185 ◽

2018 ◽

Vol 44 (2) ◽

pp. 122-129

Author(s):

Arturo Sánchez-Pérez ◽

Jesús Muñoz-Peñalver ◽

María José Moya-Villaescusa ◽

Carmen Sánchez-Matás

Keyword(s):

Placebo Group ◽

Postoperative Pain ◽

Controlled Trial ◽

Test Group ◽

Control Group ◽

Double Blind ◽

Implant Surgery ◽

Lower Pain ◽

Dexketoprofen Trometamol ◽

Group A

The fear of postoperative pain is often mentioned by patients as one of the factors that is most frequently associated with dental implants. To reduce this factor, a single oral dose of 25 mg dexketoprofen trometamol (DKT) or placebo was administered 15 minutes before implant surgery. One hundred patients who required single-implant treatments were randomly assigned to 1 of 2 blinded groups. The patients in the test group were given 25 mg DKT (DKT group), and those in the control group were given 500 mg vitamin C as a placebo (PLACEBO group). A subjective visual analogue scale of 100 mm in length was used to evaluate pain. Inflammation and complications were assessed using a 5-point Likert scale. An analysis of variance, t-tests, and a Mann-Whitney U test were performed. Among the 100 patients, 83 completed the study (there were 8 dropouts in the PLACEBO group and 9 in the DKT group). The patients who received DKT reported a lower pain intensity during the immediate postoperative period. The inflammatory response was weaker in the DKT group than the control group at 48 hours, but bleeding was greater. There were no other complications in either of the groups. In conclusion, the preemptive use of 25 mg soluble DKT administered orally 15 minutes before implant surgery can reduce the severity of immediate postoperative pain.

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Photobiomodulation Therapy Prevents Dysgeusia Chemotherapy-Induced in Breast Cancer Women Treated with Doxorubicin Plus Cyclophosphamide: A Triple-Blinded, Randomized, Placebo-Controlled Clinical Trial

10.21203/rs.3.rs-687053/v1 ◽

2021 ◽

Author(s):

Malta Cássia Emanuella Nóbrega ◽

Anna Clara Aragão Matos Carlos ◽

Manuele Carine Maciel de Alencar ◽

Eveline Fernandes Alves e Silva ◽

Victor Bruno Caitano Nogueira ◽

...

Keyword(s):

Breast Cancer ◽

Clinical Trial ◽

Placebo Group ◽

Cancer Patients ◽

Performance Status ◽

Test Group ◽

Controlled Clinical Trial ◽

Breast Cancer Patients ◽

Ecog Performance Status ◽

Chi Square

Abstract Purpose To evaluate the effectiveness of photobiomodulation (PBMT) in preventing dysgeusia in breast cancer patients treated with doxorubicin-cyclophosphamide (AC). Methods This is a phase II, randomized, triple-blind, placebo-controlled clinical trial involving 112 breast cancer patients treated with AC. The patients were divided equally into two groups: a test group treated with 2 J red laser and 3 J infrared laser on 21 points that were symmetrically distributed on the tongue on day 0 of four cycles of AC, and an equal placebo group treated with simulated PBMT to blind the patient, evaluator, and statistician. The clinicopathological and sociodemographic data, results of the hematological tests, taste test, and subjective taste analysis, and the QoL, ECOG performance status, body mass index, and other side effects were recorded. The data were analyzed using ANOVA-RM/Bonferroni, Friedman/Dunn, and chi-square/Fisher's exact tests. Results PBMT patients showed less objective and subjective taste loss (p < 0.05). On the other hand, the placebo group showed a higher ECOG status (p = 0.037) and more significant weight loss (p < 0.001) after four cycles of AC. The QoL was significantly higherin the PBMT group (p < 0.05) at all assessment periods, and PBMT treatment also reduced the incidence of cachexia (p = 0.020), anorexia (p < 0.001), diarrhea (p = 0.040), oral mucositis (p = 0.020), and vomiting (p = 0.008). Conclusion PBMT reduced the taste loss and improved the overall health status and QoL of patients with breast cancer treated with AC. Trial registration : Brazilian Clinical Trials Registry (www.ensaiosclinicos.gov.br) approval numberRBR-9qnm34y, registered on 01/05/2021

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The efficacy and safety of indocyanine green-hyaluronic acid mixture (LuminoMark™) for localization in patients with non-palpable breast lesions: a multi-center open-label parallel phase-2 clinical trial

BMC Surgery ◽

10.1186/s12893-021-01129-y ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Isaac Kim ◽

Hee Jun Choi ◽

Jai Min Ryu ◽

Se Kyung Lee ◽

Jong Han Yu ◽

...

Keyword(s):

Clinical Trial ◽

Hyaluronic Acid ◽

Test Group ◽

Acid Mixture ◽

Control Group ◽

Breast Lesions ◽

Efficacy And Safety ◽

Group 2 ◽

Palpable Breast ◽

Group 1

Abstract Background Increasing rates of breast cancer screening have been associated with an increasing frequency of non-palpable breast lesions detection. Preoperative breast lesion localization is essential for optimizing excision accuracy. This study aimed to evaluate the efficacy and safety of indocyanine green (ICG) hyaluronic acid injection as a novel mixture for localization. Methods We performed a prospective clinical trial with female patients who underwent surgery for non-palpable breast lesions. All patients were sequentially assigned to the control group (localization with activated charcoal), Test Group 1 (ICG-hyaluronic acid mixture 0.1 mL), or Test Group 2 (ICG-hyaluronic acid mixture 0.2 mL) by 1:1:1 ratio. Results A total of 44 patients were eligible for this study (Control Group = 14, Test Group 1 = 15, Test Group 2 = 15 patients). Fibroadenoma (n = 17, 38.6%) accounted for the largest proportion of diagnoses, and five patients (11.4%) were diagnosed with malignancies. There were no statistically significant differences in baseline characteristics among the three groups. The marking rate was over 86% in all groups, with no significant intergroup differences. Skin pigmentation was only observed in the control group. The mean accuracy of resection (the greatest diameter of the excised specimen divided by the greatest diameter of the preoperative lesion as observed using ultrasonography, with values closer to 1 reflecting a higher accuracy) was 3.7 in the control group, 2.2 in Test Group 1, and 2.1 in Test Group 2 (p = 0.037 between Controls and Test Group 1, p = 0.744 between Test Group 1 and Test Group 2, and p = 0.026 between Controls and Test Group 2). Conclusion ICG-hyaluronic acid injection is a novel method that was shown to accurately localize non-palpable breast lesions and was associated with no skin pigmentation. Further research is required to apply this method to malignant breast lesions. Trial registration “A Multicenter Open-label, Parallel, Phase 2 Clinical Trial to Evaluate the Efficacy and Safety of LuminoMark™ Inj. (Conc. for Fluorescence) Localization in Patients with Non-palpable Breast Lesions” was prospectively registered as a trial (ClinicalTrials. gov Identifier: NCT03743259, date of registration: May 29, 2018, https://clinicaltrials.gov/ct2/show/NCT03743259)

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Clinical effect of a herbal dentifrice on the control of plaque and gingivitis: a double-blind study

Pesquisa Odontológica Brasileira ◽

10.1590/s1517-74912003000400004 ◽

2003 ◽

Vol 17 (4) ◽

pp. 314-318 ◽

Cited By ~ 25

Author(s):

Claudio Mendes Pannuti ◽

Joyce Pereira de Mattos ◽

Paula Nini Ranoya ◽

Alberto Martins de Jesus ◽

Roberto Fraga Moreira Lotufo ◽

...

Keyword(s):

Clinical Trial ◽

Clinical Effect ◽

Test Group ◽

Control Group ◽

Double Blind Study ◽

Gingival Index ◽

Control Groups ◽

Double Blind ◽

Double Blind Clinical Trial ◽

Significant Difference

The aim of this randomized, double-blind clinical trial was to evaluate the effect of the Paradontax dentifrice on the reduction of plaque and gingivitis. Subjects were randomly allocated into either the test group (n = 15, Paradontax) or the control group (n = 15, standard dentifrice with fluoride). Plaque levels were measured using the Turesky modification of the Quigley & Hein Plaque Index (PI), and gingivitis was evaluated with the Gingival Index (GI). Subjects were asked to brush their teeth with the allocated dentifrice, three times a day, for 21 days. There was no significant difference between groups in relation to the PI and GI medians, at baseline and at the end of the 21-day period. There was no significant reduction in PI in either the test or control groups. There was a significant decrease in GI in the test group. The authors concluded that there was no difference between the dentifrices in the reduction of plaque and gingivitis.

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