Intrahepatic immune infiltrate in chronic hepatitis B and chronic hepatitis C: Similar but not the same

2021 ◽  
Author(s):  
Cecilia Graciela Giadans ◽  
Daniela Alejandra Ríos ◽  
Beatriz Ameigeiras ◽  
Leila Haddad ◽  
Elena Noemí De Matteo ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Chronic Hepatitis C ◽  
Chronic Hepatitis B ◽  
Immune Infiltrate

scholarly journals Comparing the safety, tolerability and quality of life in patients with chronic hepatitis B vs chronic hepatitis C treated with peginterferon alpha-2a

2008 ◽  
Vol 28 (4) ◽  
pp. 477-485 ◽  
Author(s):  
Patrick Marcellin ◽  
George K. K. Lau ◽  
Stefan Zeuzem ◽  
E. Jenny Heathcote ◽  
Paul J. Pockros ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Chronic Hepatitis C ◽  
Chronic Hepatitis B

Significance of biglycan and osteopontin as non-invasive markers of liver fibrosis in patients with chronic hepatitis B virus and chronic hepatitis C virus

2018 ◽  
Vol 67 (3) ◽  
pp. 681-685 ◽  
Author(s):  
Ali Sobhy ◽  
Mohammed Fakhry M. ◽  
Haitham A Azeem ◽  
Ahmed M Ashmawy ◽  
Hamed Omar Khalifa
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Chronic Hepatitis C ◽  
Chronic Hepatitis B ◽  
Non Invasive ◽  
B Virus

Several studies were performed to evaluate the degree of liver fibrosis by non-invasive markers. We aimed to assess the diagnostic value of both biglycan (BGN) and osteopontin (OPN) as non-invasive markers of hepatic fibrosis in patients with chronic hepatitis B (CHB) and chronic hepatitis C (CHC). This study was performed on 100 patients with CHB virus, 100 patients with CHC virus and 100 normal controls. All participants were subjected to the following laboratory tests: hemoglobin, platelet, alanine aminotransferase, aspartate aminotransferase, albumin, international normalized ratio, HBs Ag, hepatitis C virus (HCV) antibody, hepatitis B virus DNA, HCV RNA, liver biopsy, BGN and OPN. We found that BGN level was significantly increased in the CHB group compared with the controls (p<0.001), but the level was not different between the CHC group and the controls (p<0.96). OPN was increased in both the CHB and CHC groups compared with the controls (p<0.001). Positive correlation was found between fibrosis stages and BGN level of the CHB group (r=0.64; p<0.001) and between fibrosis stages and OPN level of the CHB (r=0.63; p<0.001) and CHC (r=0.59; p<0.03) groups. The area under the curve (AUC), sensitivity and specificity of BGN were 1.0, 100% and 100% in predicting fibrosis in patients with CHB, and 0.50, 26% and 78% in predicting fibrosis in patients with CHC. OPN had an AUC of 0.997, sensitivity of 96% and specificity of 100% in predicting fibrosis in patients with CHB, and 0.974, 96.5% and 100% in predicting fibrosis in patients with CHC. In conclusion, BGN and OPN could be considered non-invasive markers for liver fibrosis assessment.

Mortality related to chronic hepatitis B and chronic hepatitis C in France: Evidence for the role of HIV coinfection and alcohol consumption

2008 ◽  
Vol 48 (2) ◽  
pp. 200-207 ◽  
Author(s):  
Patrick Marcellin ◽  
Françoise Pequignot ◽  
Elisabeth Delarocque-Astagneau ◽  
Jean-Pierre Zarski ◽  
Nathalie Ganne ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Alcohol Consumption ◽  
Hepatitis B ◽  
Chronic Hepatitis C ◽  
Chronic Hepatitis B ◽  
Hiv Coinfection

Areal Bone Mineral Density in Pediatric Patients with Chronic Hepatitis B or Chronic Hepatitis C

2014 ◽  
Vol 95 (3) ◽  
pp. 218-221 ◽  
Author(s):  
Stefano Mora ◽  
Vania Giacomet ◽  
Alessandra Viganò ◽  
Katia Maruca ◽  
Silvia Capelli ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Chronic Hepatitis C ◽  
Chronic Hepatitis B ◽  
Bone Mineral ◽  
Pediatric Patients ◽  
Areal Bone Mineral Density ◽  
Mineral Density
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