scholarly journals Reactive oxygen species, glutathione, and vitamin E concentrations in dogs with hemolytic or nonhemolytic anemia

2020 ◽  
Vol 34 (6) ◽  
pp. 2357-2364
Author(s):  
Andrew D. Woolcock ◽  
Priscila B. S. Serpa ◽  
Andrea P. Santos ◽  
John A. Christian ◽  
George E. Moore
Keyword(s):  
Reactive Oxygen Species ◽  
Vitamin E ◽  
Reactive Oxygen ◽  
Oxygen Species

scholarly journals POTENSI BUAH MERAH (Pandanus conoideus Lam.) DALAM MENURUNKAN KADAR LDL DARAH TIKUS PUTIH

2017 ◽  
Vol 3 (1) ◽  
pp. 48 ◽  
Author(s):  
Oki Sandra Agnesa ◽  
Joko Waluyo ◽  
Jekti Prihatin ◽  
Sri Rahayu Lestari
Keyword(s):  
Reactive Oxygen Species ◽  
Vitamin E ◽  
Rattus Norvegicus ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Reactive Oxygen ◽  
Low Density ◽  
Oxygen Species ◽  
One Way Anova

Penyakit jantung koroner (PJK) terutama disebabkan oleh aterosklerosis karena hiperkolesterolimia. Oksidasi low density lipoprotein (LDL) oleh reactive oxygen species (ROS) sebagai penyebab utama proses aterogenik dapat dicegah dengan kehadiran antioksidan seperti vitamin E. Buah dan sayuran banyak mengandung vitamin. Salah satu buah yang mengandung vitamin E adalah buah merah (Pandanus conoideus Lam.). Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak buah merah terhadap kadar LDL darah pada tikus putih (Rattus norvegicus L.). Jenis penelitian ini adalah penelitian eksperimental laboratorium yang didesain mengikuti Rancangan Acak Lengkap (RAL) dengan 6 perlakuan dan 4 kali ulangan dengan parameter penelitian adalah kadar LDL darah tikus putih. Data dianalisis menggunakan one way anova dilanjutkan dengan uji Duncan 95%. Berdasarkan hasil penelitian, minyak buah merah memiliki kemampuan untuk menurunkan kadar LDL darah tikus putih.

scholarly journals The Effect Of Vitamin E Coated Tracheotomy Canula On Tracheal Reactive Oxygen Species

2008 ◽  
Author(s):  
Murat Sari ◽  
Zahide Mine Yazici ◽  
Nevruz Ozdemir ◽  
Mustafa Yanik ◽  
Cuneyd Uneri
Keyword(s):  
Reactive Oxygen Species ◽  
Vitamin E ◽  
Reactive Oxygen ◽  
Oxygen Species

Specific inhibition of mitochondrial oxidative stress suppresses inflammation and improves cardiac function in a rat pneumonia-related sepsis model

2012 ◽  
Vol 302 (9) ◽  
pp. H1847-H1859 ◽  
Author(s):  
Qun S. Zang ◽  
Hesham Sadek ◽  
David L. Maass ◽  
Bobbie Martinez ◽  
Lisha Ma ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Vitamin E ◽  
Antioxidant Capacity ◽  
Membrane Integrity ◽  
Reactive Oxygen ◽  
Myocardial Inflammation ◽  
Oxygen Species ◽  
Mitochondrial Reactive Oxygen Species ◽  
Sprague Dawley ◽  
Sepsis Model

Using a mitochondria-targeted vitamin E (Mito-Vit-E) in a rat pneumonia-related sepsis model, we examined the role of mitochondrial reactive oxygen species in sepsis-mediated myocardial inflammation and subsequent cardiac contractile dysfunction. Sepsis was produced in adult male Sprague-Dawley rats via intratracheal injection of S. pneumonia (4 × 106colony formation units per rat). A single dose of Mito-Vit-E, vitamin E, or control vehicle, at 21.5 μmol/kg, was administered 30 min postinoculation. Blood was collected, and heart tissue was harvested at various time points. Mito-Vit-E in vivo distribution was confirmed by mass spectrometry. In cardiac mitochondria, Mito-Vit-E improved total antioxidant capacity and suppressed H2O2generation, whereas vitamin E offered little effect. In cytosol, both antioxidants decreased H2O2levels, but only vitamin E strengthened antioxidant capacity. Mito-Vit-E protected mitochondrial structure and function in the heart during sepsis, demonstrated by reduction in lipid and protein oxidation, preservation of mitochondrial membrane integrity, and recovery of respiratory function. While both Mito-Vit-E and vitamin E suppressed sepsis-induced peripheral and myocardial production of proinflammatory cytokines (tumor necrosis factor-α, interleukin-1β, and interleukin-6), Mito-Vit-E exhibited significantly higher efficacy ( P < 0.05). Stronger anti-inflammatory action of Mito-Vit-E was further shown by its near-complete inhibition of sepsis-induced myeloperoxidase accumulation in myocardium, suggesting its effect on neutrophil infiltration. Echocardiography analysis indicated that Mito-Vit-E ameliorated cardiac contractility of sepsis animals, shown by improved fractional shortening and ejection fraction. Together, our data suggest that targeted scavenging of mitochondrial reactive oxygen species protects mitochondrial function, attenuates tissue-level inflammation, and improves whole organ activities in the heart during sepsis.

Effects of vitamin E and/or C on reactive oxygen species-related lead toxicity in the rat sperm

Toxicology ◽  
1998 ◽  
Vol 128 (3) ◽  
pp. 169-179 ◽  
Author(s):  
Ping-Chi Hsu ◽  
Ming-Yie Liu ◽  
Chao-Chin Hsu ◽  
Lih-Yuh Chen ◽  
Yueliang Leon Guo
Keyword(s):  
Reactive Oxygen Species ◽  
Vitamin E ◽  
Reactive Oxygen ◽  
Lead Toxicity ◽  
Oxygen Species
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