Involvement of YODA and mitogen activated protein kinase 6 in Arabidopsis post-embryogenic root development through auxin up-regulation and cell division plane orientation

Cell geometry has long been proposed to play a key role in the orientation of symmetric cell division planes. In particular, the recently proposed Besson–Dumais rule generalizes Errera’s rule and predicts that cells divide along one of the local minima of plane area. However, this rule has been tested only on tissues with rather local spherical shape and homogeneous growth. Here, we tested the application of the Besson–Dumais rule to the divisions occurring in the Arabidopsis shoot apex, which contains domains with anisotropic curvature and differential growth. We found that the Besson–Dumais rule works well in the central part of the apex, but fails to account for cell division planes in the saddle-shaped boundary region. Because curvature anisotropy and differential growth prescribe directional tensile stress in that region, we tested the putative contribution of anisotropic stress fields to cell division plane orientation at the shoot apex. To do so, we compared two division rules: geometrical (new plane along the shortest path) and mechanical (new plane along maximal tension). The mechanical division rule reproduced the enrichment of long planes observed in the boundary region. Experimental perturbation of mechanical stress pattern further supported a contribution of anisotropic tensile stress in division plane orientation. Importantly, simulations of tissues growing in an isotropic stress field, and dividing along maximal tension, provided division plane distributions comparable to those obtained with the geometrical rule. We thus propose that division plane orientation by tensile stress offers a general rule for symmetric cell division in plants.

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Arabidopsis α Aurora Kinases Function in Formative Cell Division Plane Orientation

The Plant Cell ◽

10.1105/tpc.111.089565 ◽

2011 ◽

Vol 23 (11) ◽

pp. 4013-4024 ◽

Cited By ~ 64

Author(s):

Daniël Van Damme ◽

Bert De Rybel ◽

Gustavo Gudesblat ◽

Dmitri Demidov ◽

Wim Grunewald ◽

...

Keyword(s):

Cell Division ◽

Aurora Kinases ◽

Division Plane ◽

Plane Orientation ◽

Division Plane Orientation ◽

Cell Division Plane

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Arabidopsis SABRE and CLASP interact to stabilize cell division plane orientation and planar polarity

Nature Communications ◽

10.1038/ncomms3779 ◽

2013 ◽

Vol 4 (1) ◽

Cited By ~ 38

Author(s):

Stefano Pietra ◽

Anna Gustavsson ◽

Christian Kiefer ◽

Lothar Kalmbach ◽

Per Hörstedt ◽

...

Keyword(s):

Cell Division ◽

Planar Polarity ◽

Division Plane ◽

Plane Orientation ◽

Division Plane Orientation ◽

Cell Division Plane

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Plant cortical microtubule dynamics and cell division plane orientation

10.18174/413054 ◽

2017 ◽

Author(s):

Bandan Chakrabortty

Keyword(s):

Cell Division ◽

Cortical Microtubule ◽

Microtubule Dynamics ◽

Division Plane ◽

Plane Orientation ◽

Division Plane Orientation ◽

Cell Division Plane

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Nutrient limitations alter cell division control and chromosome segregation through growth-related kinases and phosphatases

Philosophical Transactions of the Royal Society B Biological Sciences ◽

10.1098/rstb.2011.0124 ◽

2011 ◽

Vol 366 (1584) ◽

pp. 3508-3520 ◽

Cited By ~ 42

Author(s):

Mitsuhiro Yanagida ◽

Nobuyasu Ikai ◽

Mizuki Shimanuki ◽

Kenichi Sajiki

Keyword(s):

Cell Division ◽

Protein Kinase ◽

Nitrogen Source ◽

Cell Size ◽

Chromosome Segregation ◽

Mitogen Activated Protein Kinase ◽

Size Determination ◽

Glucose Limitation ◽

Mitogen Activated Protein ◽

Dependent Protein

In dividing fission yeast Schizosaccharomyces pombe cells, the balance between Wee1 kinase and Cdc25 phosphatase which control the cyclin-dependent kinase (CDK) at the G2–M transition determines the rod-shaped cell length. Under nitrogen source starvation or glucose limitation, however, cell size determination is considerably modulated, and cell size shortening occurs for wild-type cells. For several mutants of kinases or phosphatases, including CDK, target of rapamycin complex (TORC) 1 and 2, stress-responsive mitogen-activated protein kinase (MAPK) Sty1/Spc1, MAPK kinase Wis1, calcium- and calmodulin-dependent protein kinase kinase-like Ssp1, and type 2A and 2A-related phosphatases inhibitor Sds23, this cell shortening does not normally occur. In tor1 and ssp1 mutants, cell elongation is observed. Sds23 that binds to and inhibits 2A and 2A-related phosphatases is synergistic with Ssp1 in the cell size determination and survival under low glucose and nitrogen source. Tor2 (TORC1) is required for growth, whereas Tor1 (TORC2) is needed for determining division size according to different nutrient conditions. Surprisingly, in growth-diminished tor2 mutant or rapamycin-treated cells, the requirement of separase/Cut1-securin/Cut2 essential for chromosome segregation is greatly alleviated. By contrast, defects of tor1 with secruin/ cut2 or overproduction of Cut1 are additive. While Tor1 and Tor2 are opposite in their apparent functions, both may actually coordinate cell division with growth in response to the changes in nutrients.

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Mitogen activated protein kinase-1 and cell division control protein-42 are putative targets for the binding of novel natural lead molecules: a therapeutic intervention against Candida albicans

Journal of Biomolecular Structure and Dynamics ◽

10.1080/07391102.2019.1682053 ◽

2019 ◽

Vol 38 (15) ◽

pp. 4584-4599 ◽

Cited By ~ 1

Author(s):

Dharshini Gopal ◽

Aditi G Muddebihalkar ◽

Sinosh Skariyachan ◽

Akshay Uttarkar C ◽

Prinith Kaveramma ◽

...

Keyword(s):

Candida Albicans ◽

Cell Division ◽

Protein Kinase ◽

Therapeutic Intervention ◽

Mitogen Activated Protein Kinase ◽

Mitogen Activated Protein ◽

Control Protein ◽

Cell Division Control

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Noncanonical auxin signaling regulates cell division pattern during lateral root development

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1910916116 ◽

2019 ◽

Vol 116 (42) ◽

pp. 21285-21290 ◽

Cited By ~ 9

Author(s):

Rongfeng Huang ◽

Rui Zheng ◽

Jun He ◽

Zimin Zhou ◽

Jiacheng Wang ◽

...

Keyword(s):

Cell Division ◽

Root Development ◽

Lateral Root ◽

Control Cell ◽

Mapk Signaling ◽

Mitogen Activated Protein Kinase ◽

Auxin Signaling ◽

Lateral Root Development ◽

Division Pattern ◽

Mitogen Activated Protein

In both plants and animals, multiple cellular processes must be orchestrated to ensure proper organogenesis. The cell division patterns control the shape of growing organs, yet how they are precisely determined and coordinated is poorly understood. In plants, the distribution of the phytohormone auxin is tightly linked to organogenesis, including lateral root (LR) development. Nevertheless, how auxin regulates cell division pattern during lateral root development remains elusive. Here, we report that auxin activates Mitogen-Activated Protein Kinase (MAPK) signaling via transmembrane kinases (TMKs) to control cell division pattern during lateral root development. Both TMK1/4 and MKK4/5-MPK3/6 pathways are required to properly orient cell divisions, which ultimately determine lateral root development in response to auxin. We show that TMKs directly and specifically interact with and phosphorylate MKK4/5, which is required for auxin to activate MKK4/5-MPK3/6 signaling. Our data suggest that TMK-mediated noncanonical auxin signaling is required to regulate cell division pattern and connect auxin signaling to MAPK signaling, which are both essential for plant development.

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