scholarly journals Anticonvulsant discovery through animal models of status epilepticus induced by organophosphorus nerve agents and pesticides

2016 ◽  
Vol 1374 (1) ◽  
pp. 144-150 ◽  
Author(s):  
Hilary S. McCarren ◽  
John H. McDonough
Keyword(s):  
Status Epilepticus ◽  
Animal Models ◽  
Nerve Agents ◽  
Organophosphorus Nerve Agents

Catalytic Detoxification of Organophosphorus Nerve Agents by Butyrylcholinesterase-Polymer-Oxime Bioscavengers

2020 ◽  
Vol 21 (9) ◽  
pp. 3867-3877
Author(s):  
Libin Zhang ◽  
Hironobu Murata ◽  
Gabriel Amitai ◽  
Paige N. Smith ◽  
Krzysztof Matyjaszewski ◽  
...  
Keyword(s):  
Nerve Agents ◽  
Organophosphorus Nerve Agents

Amygdaloid complex anatomopathological findings in animal models of status epilepticus

2019 ◽  
pp. 106831 ◽  
Author(s):  
Cristiane Queixa Tilelli ◽  
Larissa Ribeiro Flôres ◽  
Vinicius Rosa Cota ◽  
Olagide Wagner de Castro ◽  
Norberto Garcia-Cairasco
Keyword(s):  
Status Epilepticus ◽  
Animal Models ◽  
Amygdaloid Complex

Age-Dependent Consequences of Status Epilepticus: Animal Models

Epilepsia ◽  
2007 ◽  
Vol 48 (s2) ◽  
pp. 75-82 ◽  
Author(s):  
Morris H. Scantlebury ◽  
James G. Heida ◽  
Henry J. Hasson ◽  
Jana Velíšková ◽  
Libor Velíšek ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Animal Models ◽  
Age Dependent

Animal models of status epilepticus and temporal lobe epilepsy: a narrative review

2018 ◽  
Vol 29 (7) ◽  
pp. 757-770 ◽  
Author(s):  
Nikita Nirwan ◽  
Preeti Vyas ◽  
Divya Vohora
Keyword(s):  
Animal Model ◽  
Status Epilepticus ◽  
Animal Models ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Current Literature ◽  
Clinical Characteristics ◽  
Genetic Models ◽  
Suitable Animal Model ◽  
Effective Models

Abstract Temporal lobe epilepsy (TLE) is the chronic and pharmacoresistant form of epilepsy observed in humans. The current literature is insufficient in explicating the comprehensive mechanisms underlying its pathogenesis and advancement. Consequently, the development of a suitable animal model mimicking the clinical characteristics is required. Further, the relevance of status epilepticus (SE) to animal models is dubious. SE occurs rarely in people; most epilepsy patients never experience it. The present review summarizes the established animal models of SE and TLE, along with a brief discussion of the animal models that have the distinctiveness and carries the possibility to be developed as effective models for TLE. The review not only covers the basic requirements, mechanisms, and methods of induction of each model but also focuses upon their major limitations and possible modifications for their future use. A detailed discussion on chemical, electrical, and hypoxic/ischemic models as well as a brief explanation on the genetic models, most of which are characterized by development of SE followed by neurodegeneration, is presented.

scholarly journals Galanin Modulation of Seizures and Seizure Modulation of Hippocampal Galanin in Animal Models of Status Epilepticus

1998 ◽  
Vol 18 (23) ◽  
pp. 10070-10077 ◽  
Author(s):  
Andrey M. Mazarati ◽  
Hantao Liu ◽  
Ursel Soomets ◽  
Raman Sankar ◽  
Don Shin ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Animal Models

ChemInform Abstract: Design, Synthesis and Evaluation of New α-Nucleophiles for the Hydrolysis of Organophosphorus Nerve Agents: Application to the Reactivation of Phosphorylated Acetylcholinesterase.

ChemInform ◽  
2011 ◽  
Vol 42 (52) ◽  
pp. no-no
Author(s):  
Geraldine Saint-Andre ◽  
Maria Kliachyna ◽  
Sanjeevarao Kodepelly ◽  
Ludivine Louise-Leriche ◽  
Emilie Gillon ◽  
...  
Keyword(s):  
Nerve Agents ◽  
Design Synthesis ◽  
Organophosphorus Nerve Agents ◽  
Hydrolysis Of

Phosphylated tyrosine in albumin as a biomarker of exposure to organophosphorus nerve agents

2007 ◽  
Vol 81 (9) ◽  
pp. 627-639 ◽  
Author(s):  
Nichola H. Williams ◽  
John M. Harrison ◽  
Robert W. Read ◽  
Robin M. Black
Keyword(s):  
Nerve Agents ◽  
Biomarker Of Exposure ◽  
Organophosphorus Nerve Agents ◽  
Phosphylated Tyrosine

Development of a Guinea Pig Model for Low-Dose, Long-Term Exposure to Organophosphorus Nerve Agents

2004 ◽  
Vol 14 (3) ◽  
pp. 183-194 ◽  
Author(s):  
Chessley R. Atchison ◽  
Robert E. Sheridan ◽  
Steven M. Duniho ◽  
Tsung-Ming Shih
Keyword(s):  
Guinea Pig ◽  
Low Dose ◽  
Nerve Agents ◽  
Pig Model ◽  
Organophosphorus Nerve Agents ◽  
Guinea Pig Model

Zirconium-Based Metal–Organic Frameworks for the Catalytic Hydrolysis of Organophosphorus Nerve Agents

2020 ◽  
Vol 12 (13) ◽  
pp. 14702-14720 ◽  
Author(s):  
Kent O. Kirlikovali ◽  
Zhijie Chen ◽  
Timur Islamoglu ◽  
Joseph T. Hupp ◽  
Omar K. Farha
Keyword(s):  
Metal Organic Frameworks ◽  
Nerve Agents ◽  
Catalytic Hydrolysis ◽  
Organophosphorus Nerve Agents ◽  
Metal Organic ◽  
Hydrolysis Of
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