Could medications and biologic factors affect post‐orthodontic tooth movement changes? A systematic review of animal studies

ABSTRACT Objectives To critically appraise the current evidence available from animal studies pertaining to the effectiveness of platelet-rich plasma (PRP) in accelerating orthodontic tooth movement. Materials and Methods Electronic searches of nine databases were conducted up to June 2020, followed by a hand search of the reference list of eligible studies. The study design required was prospective controlled animal studies. The primary outcome assessed was the rate of orthodontic tooth movement. The secondary outcome evaluated was histological changes after PRP application. Following study retrieval and selection, relevant data were extracted. Risk-of-bias (RoB) assessment was done using the Systematic Review Center for Laboratory Animal Experimentation's Risk of Bias Tool (SYRCLE's Risk of Bias Tool). Two review authors conducted the work of searching, study selection, and quality assessment independently and in duplicate. Results Of 193 studies, 5 animal studies were included in this systematic review. Three studies found a positive correlation between PRP injection and tooth movement acceleration, along with corresponding histological changes. Two studies detected no significant difference in tooth movement rate after PRP application. Conclusions Based on the current limited evidence, the efficacy of PRP on tooth movement acceleration remains debatable. More well-designed randomized controlled trials involving humans are called for to obtain more clinically significant conclusions.

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Impact of Vibration on the Levels of Biomarkers: A Systematic Review

The Journal of Indian Orthodontic Society ◽

10.1177/03015742211019520 ◽

2021 ◽

pp. 030157422110195

Author(s):

Ashish Agrawal ◽

TM Chou

Keyword(s):

Systematic Review ◽

Web Of Science ◽

Tooth Movement ◽

Orthodontic Tooth Movement ◽

Cochrane Collaboration ◽

Risk Of Bias ◽

Cochrane Library ◽

Inclusion Criteria ◽

Electronic Search ◽

Proquest Dissertation

Introduction: The objective of this systematic review is to assess the effect of vibrational force on biomarkers for orthodontic tooth movement. Methods: An electronic search was conducted for relevant studies (up to December 31, 2020) on the following databases: Pubmed, Google scholar, Web of Science, Cochrane Library, Wiley Library, and ProQuest Dissertation Abstracts and Thesis database. Hand searching of selected orthodontic journals was also undertaken. The selected studies were assessed for the risk of bias in Cochrane collaboration risk of bias tool. The “traffic plot” and “weighted plot” risk of bias distribution are designed in the RoB 2 tool. The 2 authors extracted the data and analyzed it. Results: Six studies fulfilled the inclusion criteria. The risks of biases were high for 4, low and some concern for other 2 studies. The biomarkers, medium, device, frequency and duration of device, as well as other data were extracted. The outcomes of the studies were found to be heterogenous. Conclusion: One study showed highly statistically significant levels of IL-1 beta with <.001. Rate of tooth movement was correlated with levels of released biomarkers under the influence of vibrational force in 3 studies, but it was found to be significant only in 1 study. It was further observed that vibration does not have any significant reduction in pain and discomfort.

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Influence of Intermittent Parathyroid Hormone (PTH) Administration on the Outcomes of Orthodontic Tooth Movement—A Systematic Review

Applied Sciences ◽

10.3390/app11115268 ◽

2021 ◽

Vol 11 (11) ◽

pp. 5268

Author(s):

Zohaib Khurshid ◽

Faris Yahya Asiri

Keyword(s):

Parathyroid Hormone ◽

Animal Studies ◽

Tooth Movement ◽

Orthodontic Tooth Movement ◽

Inclusion Criteria ◽

Medical Subject Headings ◽

Periodontal Tissues ◽

Minimal Bias ◽

Intermittent Pth

Objective: The aim of this review is to summarize the effects of local and systemic PTH administration on periodontal tissues during orthodontic tooth movement. Materials and methods: An electronic search was conducted on the following databases: PubMed/MEDLINE, Google Scholar, SCOPUS and Embase. On PubMed/MEDLINE, the Medical Subject Headings (MeSH) keywords used were: “orthodontic tooth movement” OR (“tooth” (All Fields) AND “tooth movement” (All Fields)) OR “tooth movement” (All Fields)) AND (“parathyroid hormone”); all studies included using CONSORT. Results: After elimination of duplicates and articles not meeting our inclusion criteria, seven animal studies were included in this review. Although the majority of the studies suggest that PTH may a have a favorable outcome on OTM, most studies were found to have several sources of bias. Conclusion: Animal studies with minimal bias and long-term clinical studies are needed to ascertain the efficacy of intermittent PTH administration in improving the rate and retention of OTM.

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Effectiveness of adjunctive interventions for accelerating orthodontic tooth movement: a systematic review of systematic reviews

Journal of Oral Rehabilitation ◽

10.1111/joor.12509 ◽

2017 ◽

Vol 44 (8) ◽

pp. 636-654 ◽

Cited By ~ 22

Author(s):

J. Yi ◽

J. Xiao ◽

H. Li ◽

Y. Li ◽

X. Li ◽

...

Keyword(s):

Systematic Review ◽

Systematic Reviews ◽

Tooth Movement ◽

Orthodontic Tooth Movement

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Effects of vibrational devices on orthodontic tooth movement: A systematic review

American Journal of Orthodontics and Dentofacial Orthopedics ◽

10.1016/j.ajodo.2018.07.012 ◽

2018 ◽

Vol 154 (6) ◽

pp. 768-779 ◽

Cited By ~ 2

Author(s):

Aljazi Aljabaa ◽

Khalid Almoammar ◽

Abdullah Aldrees ◽

Greg Huang

Keyword(s):

Systematic Review ◽

Tooth Movement ◽

Orthodontic Tooth Movement

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Does the rate of orthodontic tooth movement change during the estrus cycle? A systematic review based on animal studies

BMC Oral Health ◽

10.1186/s12903-021-01875-8 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Noura Saeed Sultan Almidfa ◽

Athanasios E. Athanasiou ◽

Miltiadis A. Makrygiannakis ◽

Eleftherios G. Kaklamanos

Keyword(s):

Animal Studies ◽

Tooth Movement ◽

Citation Index ◽

Cochrane Review ◽

Orthodontic Tooth Movement ◽

Risk Of Bias ◽

Cochrane Library ◽

Hormonal Changes ◽

Estrus Cycle ◽

Russian Science Citation Index

Abstract Background As the fluctuation of sex hormone levels in menstruating women results in periodical effects in bone metabolism, understanding the implications for tooth movement could be of benefit to the orthodontist. This type of research presents practical and ethical problems in humans, but animal models could provide useful information. Our objective was to systematically investigate the available evidence on the question whether the rate of orthodontic tooth movement varies between the different stages of the estrus cycle in animals. Methods Unrestricted searches in 7 databases and manual searching of the reference lists in relevant studies were performed up to February 2021 (Medline [PubMed], CENTRAL [Cochrane Library; includes records from Embase, CINAHL, ClinicalTrials.gov, WHO's ICTRP, KoreaMed, Cochrane Review Groups’ Specialized Registers, and records identified by handsearching], Cochrane Database of Systematic Reviews [Cochrane Library], Scopus, Web of Knowledge [including Web of Science Core Collection, KCI Korean Journal Database, Russian Science Citation Index, SciELO Citation Index and Zoological Record], Arab World Research Source [EBSCO] and ProQuest Dissertation and Theses [ProQuest]). Our search focused on prospective controlled animal studies, whose samples included female subjects of any species that were quantitatively comparing the amount of tooth movement in the different stages of the estrus cycle. Following study retrieval and selection, relevant data was extracted, and the risk of bias was assessed using the SYRCLE’s Risk of Bias Tool. Results From the finally assessed records, 3 studies met the inclusion criteria. Two of the studies experimented on Wistar rats, whereas the other on cats. Tooth movement was induced by expansion or coil springs. The rate of orthodontic tooth movement was increased during the stages of the estrus cycle when oestrogen and/or progesterone levels were lower. The risk of bias in the retrieved studies was assessed to be unclear. Conclusion Hormonal changes during the estrus cycle may affect the rate of orthodontic tooth movement. Although these animal experiment results should be approached cautiously regarding their translational potential, it could be useful to consider the possible impact of these physiological changes in the clinical setting until more information becomes available. Registration: PROSPERO (CRD42021158069).

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