intermittent pth
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2022 ◽  
Vol 23 (2) ◽  
pp. 940
Author(s):  
René St-Arnaud ◽  
Martin Pellicelli ◽  
Mahmoud Ismail ◽  
Alice Arabian ◽  
Toghrul Jafarov ◽  
...  

PTH induces phosphorylation of the transcriptional coregulator NACA on serine 99 through Gαs and PKA. This leads to nuclear translocation of NACA and expression of the target gene Lrp6, encoding a coreceptor of the PTH receptor (PTH1R) necessary for full anabolic response to intermittent PTH (iPTH) treatment. We hypothesized that maintaining enough functional PTH1R/LRP6 coreceptor complexes at the plasma membrane through NACA-dependent Lrp6 transcription is important to ensure maximal response to iPTH. To test this model, we generated compound heterozygous mice in which one allele each of Naca and Lrp6 is inactivated in osteoblasts and osteocytes, using a knock-in strain with a Naca99 Ser-to-Ala mutation and an Lrp6 floxed strain (test genotype: Naca99S/A; Lrp6+/fl;OCN-Cre). Four-month-old females were injected with vehicle or 100 μg/kg PTH(1-34) once daily, 5 days a week for 4 weeks. Control mice showed significant increases in vertebral trabecular bone mass and biomechanical properties that were abolished in compound heterozygotes. Lrp6 expression was reduced in compound heterozygotes vs. controls. The iPTH treatment increased Alpl and Col1a1 mRNA levels in the control but not in the test group. These results confirm that NACA and LRP6 form part of a common genetic pathway that is necessary for the full anabolic effect of iPTH.


2021 ◽  
Vol 11 (11) ◽  
pp. 5268
Author(s):  
Zohaib Khurshid ◽  
Faris Yahya Asiri

Objective: The aim of this review is to summarize the effects of local and systemic PTH administration on periodontal tissues during orthodontic tooth movement. Materials and methods: An electronic search was conducted on the following databases: PubMed/MEDLINE, Google Scholar, SCOPUS and Embase. On PubMed/MEDLINE, the Medical Subject Headings (MeSH) keywords used were: “orthodontic tooth movement” OR (“tooth” (All Fields) AND “tooth movement” (All Fields)) OR “tooth movement” (All Fields)) AND (“parathyroid hormone”); all studies included using CONSORT. Results: After elimination of duplicates and articles not meeting our inclusion criteria, seven animal studies were included in this review. Although the majority of the studies suggest that PTH may a have a favorable outcome on OTM, most studies were found to have several sources of bias. Conclusion: Animal studies with minimal bias and long-term clinical studies are needed to ascertain the efficacy of intermittent PTH administration in improving the rate and retention of OTM.


Author(s):  
Shen Zhao ◽  
Tomoka Hasegawa ◽  
Hiromi Hongo ◽  
Tomomaya Yamamoto ◽  
Miki Abe ◽  
...  

2020 ◽  
Vol 23 (3) ◽  
pp. 511-519 ◽  
Author(s):  
Jenifer Freitas Campos ◽  
Aline Gomes Hidalgo Mierzwa ◽  
Mariana Freitas-Jesus ◽  
Marise Lazaretti-Castro ◽  
Keico Okino Nonaka ◽  
...  

Bone ◽  
2020 ◽  
Vol 136 ◽  
pp. 115370
Author(s):  
Kenji Kosugi ◽  
Takafumi Tajima ◽  
Kunitaka Menuki ◽  
Kayoko Furukawa Okuma ◽  
Kotaro Tokuda ◽  
...  

2018 ◽  
Vol 124 (6) ◽  
pp. 1426-1437 ◽  
Author(s):  
Seungyong Lee ◽  
Ashley Bice ◽  
Brianna Hood ◽  
Juan Ruiz ◽  
Jahyun Kim ◽  
...  

Inflammation coincides with diminished marrow function, vasodilation of blood vessels, and bone mass. Intermittent parathyroid hormone (PTH) administration independently improves marrow and vascular function, potentially impacting bone accrual. Currently, the influence of marrow and intermittent PTH administration on aged bone blood vessels has not been examined. Vasodilation of the femoral principal nutrient artery (PNA) was assessed in the presence and absence of marrow. Furthermore, we determined the influence of PTH 1–34 on 1) endothelium-dependent vasodilation and signaling pathways [i.e., nitric oxide (NO) and prostacyclin (PGI2)], 2) endothelium-independent vasodilation, 3) cytokine production by marrow cells, and 4) bone microarchitecture and bone static and dynamic properties. Young (4–6 mo) and old (22–24 mo) male Fischer-344 rats were treated with PTH 1–34 or a vehicle for 2 wk. In the absence and presence of marrow, femoral PNAs were given cumulative doses of acetylcholine, with and without the NO and PGI2blockers, and diethylamine NONOate. Marrow-derived cytokines and bone parameters in the distal femur were assessed. Exposure to marrow diminished endothelium-dependent vasodilation in young rats. Reduced bone volume and NO-mediated vasodilation occurred with old age and were partially reversed with PTH. Additionally, PTH treatment in old rats restored endothelium-dependent vasodilation in the presence of marrow and augmented IL-10, an anti-inflammatory cytokine. Endothelium-independent vasodilation was unaltered, and PTH treatment reduced osteoid surfaces in old rats. In conclusion, the marrow microenvironment reduced vascular function in young rats, and PTH treatment improved the marrow microenvironment and vasodilation with age.NEW & NOTEWORTHY This study investigated the influence of the marrow microenvironment on bone vascular function in young and old rats. An inflamed marrow microenvironment may reduce vasodilator capacity of bone blood vessels, diminishing delivery of blood flow to the skeleton. In young rats, the presence of the marrow reduced vasodilation in the femoral principal nutrient artery (PNA). However, intermittent parathyroid hormone administration (i.e., a treatment for osteoporosis) improved the marrow microenvironment and vasodilator capacity in old PNAs.


2018 ◽  
Vol 16 (1) ◽  
Author(s):  
Ji-Hye Kim ◽  
Ae Ri Kim ◽  
Yun Hui Choi ◽  
Aeryun Kim ◽  
Yongsung Sohn ◽  
...  

EMBO Reports ◽  
2017 ◽  
Vol 19 (1) ◽  
pp. 156-171 ◽  
Author(s):  
Mingcan Yu ◽  
Patrizia D'Amelio ◽  
Abdul Malik Tyagi ◽  
Chiara Vaccaro ◽  
Jau‐Yi Li ◽  
...  

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