Rapid response to secukinumab in a 5‐year‐old with deficiency of the interleukin‐36 receptor antagonist (DITRA) with severe scalp and nail involvement

2021 ◽  
Author(s):  
Guo Jing ◽  
Wang Bin ◽  
Zhang Zhen Ying
Keyword(s):  
Receptor Antagonist ◽  
Rapid Response ◽  
Nail Involvement

Pharmacological analysis of components of the change in transmural potential difference evoked by distension of rat proximal small intestine in vivo

2008 ◽  
Vol 294 (1) ◽  
pp. G165-G173 ◽  
Author(s):  
Marie H. Larsson ◽  
Maria Sapnara ◽  
Evan A. Thomas ◽  
Joel C. Bornstein ◽  
Erik Lindström ◽  
...  
Keyword(s):  
Small Intestine ◽  
Receptor Antagonist ◽  
Time Course ◽  
Slow Component ◽  
Chloride Secretion ◽  
Rapid Response ◽  
Sustained Response ◽  
Potential Difference ◽  
Reflex Response

The reflex response to distension of the small intestine in vivo is complex and not well understood. The aim of this study was to characterize the neural mechanisms contributing to the complex time course of the intestinal secretory response to distension. Transmucosal potential difference (PD) was used as a marker for mucosal chloride secretion, which reflects the activity of the secretomotor neurons. Graded distensions (5, 10, and 20 mmHg) of distal rat duodenum with saline for 5 min induced a biphasic PD response with an initial peak (rapid response) followed by a plateau (sustained response). The rapid response was significantly reduced by the neural blockers tetrodotoxin and lidocaine (given serosally) and by intravenous (iv) administration of the ganglionic blocker hexamethonium and the NK1 receptor antagonist SR-140333. Serosal TTX and iv SR-140333 significantly reduced the sustained response, which was also reduced by the NK3 receptor antagonist talnetant and by the vasoactive intestinal polypeptide (VPAC) receptor antagonist [4Cl-d-Phe6, Leu17]-VIP. Serosal lidocaine and iv hexamethonium had no significant effect on this component. Inhibition of nitric oxide synthase had no effect on any of the components of the PD response to distension. The PD response to distension thus seems to consist of two components, a rapidly activating and adapting component operating via nicotinic transmission and NK1 receptors, and a slow component operating via VIP-ergic transmission and involving both NK1 and NK3 receptors.

The novel histamine H2 receptor antagonist FRG-8813 prevents delay of wound repair induced by hydrogen peroxide in a rabbit gastric epithelial cell system

1998 ◽  
Vol 13 (11-s4) ◽  
pp. S209-S213
Author(s):  
NOBUHIRO SATO ◽  
SUMIO WATANABE ◽  
XIAN-EN WANG ◽  
TARO OSADA ◽  
HIROSHI TANAKA ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Epithelial Cell ◽  
Receptor Antagonist ◽  
Wound Repair ◽  
Cell System ◽  
The Novel ◽  
H2 Receptor Antagonist ◽  
Histamine H2 Receptor ◽  
H2 Receptor ◽  
Histamine H2 Receptor Antagonist

Colonic effects of TAK-637: A novel NK, receptor antagonist

2001 ◽  
Vol 120 (5) ◽  
pp. A331-A331
Author(s):  
K VENKOVA ◽  
K TYLER ◽  
D SUTKOWSKIMARKMANN
Keyword(s):  
Receptor Antagonist ◽  
Nk Receptor

Rapid Response Systems Now Established at 2,900 Hospitals

2010 ◽  
Vol 3 (3) ◽  
pp. 1-25
Author(s):  
MARY ELLEN SCHNEIDER
Keyword(s):  
Rapid Response ◽  
Rapid Response Systems ◽  
Response Systems

Data Fail to Back Rapid Response Teams

2011 ◽  
Vol 4 (6) ◽  
pp. 8-9
Author(s):  
MARY ANN MOON
Keyword(s):  
Rapid Response ◽  
Rapid Response Teams

Microinjection of NMDA Receptor Antagonist AP5 to the Telencephalon

2001 ◽  
Author(s):  
Jennifer Bazner ◽  
Min Qi ◽  
Xiaojuan Xu
Keyword(s):  
Nmda Receptor ◽  
Receptor Antagonist ◽  
Nmda Receptor Antagonist
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