Ethnic variation in the correlation between waist to height ratio and total daily insulin requirement in children with type 1 diabetes: a cross-sectional study

Abstract Background Double Diabetes (DD), type 1 diabetes (T1DM) + insulin resistance (IR), is associated with increased risk of micro/macro-vascular complications and mortality. Obesity can contribute to the development of DD. This study explored the prevalence of overweight/obesity and their association with DD in adults with T1DM. Methods Cross-sectional study of consecutive adults with T1DM attending diabetes clinics in a secondary care hospital (January-November 2019). Estimated glucose disposal rate (eGDR) was used as a marker of IR, and an eGDR < 8 was used to identify individuals with DD. Results One hundred seven adults with T1DM were included; female/male: 51/56; age [median (inter-quartile range): 30.0 (23–51) years]; BMI 25.4 (22.8–30.0) kg/m2. Overweight/obesity prevalence was 57/107 (53.3 %) [overweight: 30/107 (28 %); obesity: 27/107 (25.2 %)]. Compared to those with normal BMI, individuals with T1DM and overweight/obesity had longer diabetes duration; higher total daily insulin dose; and higher DD prevalence: 48/57 (84.2 %) vs. 14/50 (28 %) (p < 0.01); with similar HbA1c. BMI correlated with total daily insulin dose (rho = 0.55; p < 0.01). Individuals with DD were older, had longer duration of diabetes, higher HbA1c, and more adverse lipid profile and microalbuminuria compared to those without DD. Conclusions Overweight/obesity is very common in adults with T1DM, and is associated with double diabetes. BMI is positively associated with total insulin dose. Double diabetes is associated with adverse cardiovascular risk profile and is also common in lean individuals with T1DM. Further research is needed to examine the impact of overweight/obesity in people with T1DM and whether weight loss in this population can improve diabetes-related outcomes.

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The association between overweight/obesity and double diabetes in adults with type 1 diabetes; a cross-sectional study

10.21203/rs.3.rs-256189/v1 ◽

2021 ◽

Author(s):

Nathan Cantley ◽

Kathryn Lonnen ◽

Ioannis Kyrou ◽

Abd Tahrani ◽

Hassan Kahal

Keyword(s):

Type 1 Diabetes ◽

Insulin Dose ◽

Cross Sectional Study ◽

Care Hospital ◽

Sectional Study ◽

Cross Sectional ◽

Daily Insulin ◽

Daily Insulin Dose ◽

Double Diabetes

Abstract Backrgound: Double Diabetes (DD), type 1 diabetes (T1DM) + insulin resistance (IR), is associated with increased risk of micro/macro-vascular complications and mortality. Obesity can contribute to the development of DD. This study explored the prevalence of overweight/obesity and their association with DD in adults with T1DM.Methods: Cross-sectional study of consecutive adults with T1DM attending diabetes clinics in a secondary care hospital (January-November 2019). Estimated glucose disposal rate (eGDR) was used as a marker of IR, and an eGDR <8 was used to identify individuals with DD. Results: 107 adults with T1DM were included; female/male: 51/56; age [median (inter-quartile range): 30.0 (23-51) years]; BMI 25.4 (22.8-30.0) kg/m2. Overweight/obesity prevalence was 57/107 (53.3%) [overweight: 30/107 (28%); obesity: 27/107 (25.2%)]. Compared to those with normal BMI, individuals with T1DM and overweight/obesity had longer diabetes duration; higher total daily insulin dose; and higher DD prevalence: 48/57 (84.2%) vs 14/50 (28%) (p<0.01); with similar HbA1c. BMI correlated with total daily insulin dose (rho=0.55; p<0.01). Individuals with DD were older, had longer duration of diabetes, higher HbA1c, and more adverse lipid profile and microalbuminuria compared to those without DD.Conclusions: Overweight/obesity is very common in adults with T1DM, and is associated with double diabetes. BMI is positively associated with total insulin dose. Double diabetes is associated with adverse cardiovascular risk profile and is also common in lean individuals with T1DM. Further research is needed to examine the impact of overweight/obesity in people with T1DM and whether weight loss in this population can improve diabetes-related outcomes.

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Glycemic control associated factors in type 1 diabetes mellitus patients: a cross sectional study

Diabetology & Metabolic Syndrome ◽

10.1186/1758-5996-7-s1-a46 ◽

2015 ◽

Vol 7 (S1) ◽

Author(s):

Patrícia Ramos Guzatti ◽

Amely PS Balthazar ◽

Maria Heloisa Busi da Silva Canalli ◽

Thais Fagnani Machado

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Glycemic Control ◽

Type 1 Diabetes Mellitus ◽

Associated Factors ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

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24-hour central aortic systolic pressure and 24-hour central pulse pressure are related to diabetic complications in type 1 diabetes – a cross-sectional study

Cardiovascular Diabetology ◽

10.1186/1475-2840-12-122 ◽

2013 ◽

Vol 12 (1) ◽

pp. 122 ◽

Cited By ~ 16

Author(s):

Simone Theilade ◽

Maria Lajer ◽

Tine Hansen ◽

Christel Joergensen ◽

Frederik Persson ◽

...

Keyword(s):

Type 1 Diabetes ◽

Diabetic Complications ◽

Pulse Pressure ◽

Systolic Pressure ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Central Pulse Pressure

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Insulin micro-secretion in Type 1 diabetes and related microRNA profiles

Scientific Reports ◽

10.1038/s41598-021-90856-6 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Andrzej S. Januszewski ◽

Yoon Hi Cho ◽

Mugdha V. Joglekar ◽

Ryan J. Farr ◽

Emma S. Scott ◽

...

Keyword(s):

Type 1 Diabetes ◽

Cross Sectional Study ◽

Diabetes Duration ◽

Adult Onset ◽

Sectional Study ◽

Childhood Onset ◽

Cross Sectional ◽

C Peptide ◽

Adult Onset Diabetes

AbstractThe aim of this cross-sectional study was to compare plasma C-peptide presence and levels in people without diabetes (CON) and with Type 1 diabetes and relate C-peptide status to clinical factors. In a subset we evaluated 50 microRNAs (miRs) previously implicated in beta-cell death and associations with clinical status and C-peptide levels. Diabetes age of onset was stratified as adult (≥ 18 y.o) or childhood (< 18 y.o.), and diabetes duration was stratified as ≤ 10 years, 10–20 years and > 20 years. Plasma C-peptide was measured by ultrasensitive ELISA. Plasma miRs were quantified using TaqMan probe-primer mix on an OpenArray platform. C-peptide was detectable in 55.3% of (n = 349) people with diabetes, including 64.1% of adults and 34.0% of youth with diabetes, p < 0.0001 and in all (n = 253) participants without diabetes (CON). C-peptide levels, when detectable, were lower in the individuals with diabetes than in the CON group [median lower quartile (LQ)–upper quartile (UQ)] 5.0 (2.6–28.7) versus 650.9 (401.2–732.4) pmol/L respectively, p < 0.0001 and lower in childhood versus adult-onset diabetes [median (LQ–UQ) 4.2 (2.6–12.2) pmol/L vs. 8.0 (2.3–80.5) pmol/L, p = 0.02, respectively]. In the childhood-onset group more people with longer diabetes duration (> 20 years) had detectable C-peptide (60%) than in those with shorter diabetes duration (39%, p for trend < 0.05). Nine miRs significantly correlated with detectable C-peptide levels in people with diabetes and 16 miRs correlated with C-peptide levels in CON. Our cross-sectional study results are supportive of (a) greater beta-cell function loss in younger onset Type 1 diabetes; (b) persistent insulin secretion in adult-onset diabetes and possibly regenerative secretion in childhood-onset long diabetes duration; and (c) relationships of C-peptide levels with circulating miRs. Confirmatory clinical studies and related basic science studies are merited.

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BMI, waist to height ratio and waist circumference as a screening tool for hypertension in hospital out patients: a cross-sectional study

10.21203/rs.3.rs-66161/v2 ◽

2020 ◽

Author(s):

Rajan Shrestha ◽

Bijay Khatri ◽

Madan P. Upadhyay ◽

Janak R. Bhattarai ◽

Manish Kayastha ◽

...

Keyword(s):

Risk Factor ◽

Waist Circumference ◽

Low Income ◽

Cross Sectional Study ◽

Anthropometric Measurement ◽

Sectional Study ◽

Height Ratio ◽

Cross Sectional ◽

Obesity And Overweight ◽

Waist To Height Ratio

Abstract BackgroundObesity has become a global epidemic and an important risk factor for non-communicable diseases. Earlier thought to be a problem of developed world, it has now become a problem of low- and middle-income countries like Nepal. In absence of a routine surveillance or a registry system, the actual burden and trend of obesity in Nepal is unknown. Obesity and overweight are recognized risk factors for hypertension and associated with cardiovascular disease. The aim of the study was to find out burden of obesity, using three commonly employed metrics in hospital outpatient setting of a low-income country as predictors of hypertension, and compare ability of different anthropometric measurements through a non-inferiority study to predict hypertension.MethodsThis cross-sectional study was conducted among 40-69 years outpatients in a tertiary Eye and ENT hospital in a semi-urban area of Nepal among randomly selected 2,256 participants from 6,769 outpatients who were evaluated in Health Promotion and risk factor screening service. We did correlation analysis to determine the relationship between anthropometric measurement and blood pressure. The area under the Receiver Operating characteristic curve of Body Mass Index (BMI), Waist to Height Ratio (WHtR) and Waist Circumference (WC) was calculated and compared. ResultsThe prevalence of obesity and overweight by BMI was 16.09% and 42.20% respectively; by Waist-to-Height-Ratio was 32.76% which is two times higher than obesity measured by BMI. High waist circumference was observed among 66.76% participants. Female participants had greater prevalence of high WC (77.46%) than male (53.73%) (p<0.001). Prevalence of hypertension and pre-hypertension was 40.67% and 36.77% respectively. The areas under the curve were significantly higher than 0.5 for BMI (0.593), WHtR (0.602) and WC (0.610).ConclusionWaist circumference correlated well with obesity and hypertension. It also had higher predicting ability than WHtR and BMI to predict hypertension. Waist circumference thus proved to be non-inferior to two other commonly used metrics. It proved superior in detecting obesity in female. This simple and inexpensive tape measurement may play an important role in future diagnosis of obesity and prediction of HTN in resource constrained settings of developing countries.

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