scholarly journals Estimating plasma glucose with the FreeStyle Libre Pro continuous glucose monitor during oral glucose tolerance tests in youth without diabetes

2019 ◽  
Vol 20 (8) ◽  
pp. 1072-1079 ◽  
Author(s):  
Nejla Ghane ◽  
Miranda M. Broadney ◽  
Elisabeth K. Davis ◽  
Robert W. Trenschel ◽  
Shavonne M. Collins ◽  
...  
Author(s):  
S T Cummings ◽  
C G Fraser

A series of ten 75g oral glucose tolerance tests was carried out on each of 14 apparently healthy subjects. The analytical, intra-individual and inter-individual components of variation were calculated by nested ANOVA following duplicate analyses of capillary plasma glucose under optimal conditions. The analyses met the objectively set analytical goal of CV ≤2·2%. There was considerable intra-individual variation, but no subject was ever classified as diabetic or having impaired glucose tolerance. Recent criteria for interpretation of results must be used since conventional population-based reference values are not adequate. Serial results from an individual must differ by more than 0·7 mmol/L for fasting specimens and at least 1·6 mmol/L for other specimens for a statistically significant ( P ≤ 0·05) change to have occurred.


The Lancet ◽  
1998 ◽  
Vol 352 (9135) ◽  
pp. 1223 ◽  
Author(s):  
Keiji Yoshioka ◽  
Sadayoshi Yokoh ◽  
Toshihide Yoshida

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 684
Author(s):  
Benjamin J. Stubbs ◽  
Keith Frankston ◽  
Marcel Ramos ◽  
Nancy Laranjo ◽  
Frank M. Sacks ◽  
...  

We describe an open source software package, ogttMetrics, to compute diverse measures of glucose metabolism derived from oral glucose tolerance tests (OGTTs). Tools are provided to organize, visualize and compare OGTT data from large cohorts. Numerical difficulties in estimation of parameters of the Bergman minimal model are described, and in one large clinical trial, the simpler closed form index of Matsuda is observed to lead to similar rankings of individuals with respect to insulin sensitivity, and similar inferences concerning effects of modifications to carbohydrate content and glycemic index of experimental diets.


1965 ◽  
Vol 208 (1) ◽  
pp. 115-117 ◽  
Author(s):  
Harry Sobel ◽  
George C. Haberfelde ◽  
Albert E. Reeves

Guinea pigs were exposed continuously to a temperature of 2–4 C for 6 months. They were then reacclimatized to room temperature, and after 4–6 months certain tests were carried out. During control collections and following exposure to cold the previously cold-exposed animals exhibited urinary corticoid excretion values which were approximately 10% below those of their controls. Following intraperitoneal injection of ACTH the response was approximately 20% greater. However, these differences were not statistically significant. Oral glucose tolerance tests revealed definite evidence of reduction in tolerance in the previously cold-exposed animals. Six animals exhibited 150-min values which exceeded by more than 20 mg/ 100 ml the highest value observed in the controls. Fourteen others whose values fell within this limit exhibited a statistically significant increase in the 150-min value as compared with the controls. The PBI values were the same in each group. There were no histological residues in the pituitary, adrenal, pancreas, and thyroid glands.


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