Extract from Ascaris suum and N‐acetyl‐L‐cysteine induces an immunosuppressant effect in model of autoimmune hepatitis

2021 ◽  
Author(s):  
Roeckson Carlos Peixoto Silva ◽  
Raul Penaforte Correia Silva ◽  
Fabrício Oliveira Souto ◽  
Virginia Maria Barros Lorena ◽  
André de Lima Aires ◽  
...  
Keyword(s):  
Autoimmune Hepatitis ◽  
Ascaris Suum ◽  
Immunosuppressant Effect

Immunomodulation of liver injury by Ascaris suum extract in an experimental model of autoimmune hepatitis

2014 ◽  
Vol 113 (9) ◽  
pp. 3309-3317 ◽  
Author(s):  
Wheverton C. Nascimento ◽  
Roeckson P. Silva ◽  
Erica S. Fernandes ◽  
Maria C. Silva ◽  
Gabriela C. Holanda ◽  
...  
Keyword(s):  
Liver Injury ◽  
Autoimmune Hepatitis ◽  
Experimental Model ◽  
Ascaris Suum

scholarly journals Extract of Ascaris suum induces TGF-β and early production of IgG1 in experimental autoimmune hepatitis

2020 ◽  
Vol 29 (2) ◽  
Author(s):  
Roeckson Carlos Peixoto Silva ◽  
Raul Penaforte Correia da Silva ◽  
Maria da Conceição Silva ◽  
Wheverton Ricardo Correia do Nascimento ◽  
Vlaudia Maria Assis Costa ◽  
...  
Keyword(s):  
Immune Response ◽  
Autoimmune Hepatitis ◽  
Concanavalin A ◽  
Ascaris Suum ◽  
Response Control ◽  
Th1 Response ◽  
Early Production ◽  
Significant Production ◽  
Experimental Autoimmune

Abstract In experimental autoimmune hepatitis (EAH) of Th1 profile, an extract of adult Ascaris suum worms (ASC) was previously found to deviate the immune response to a Th2/IL-10 pattern. Here, the effects of treatment with ASC on production of TGF-β and the anti-Ascaris isotypes IgG1 and IgG2a in EAH were evaluated. EAH was induced in BALB/c mice, intravenously with concanavalin A. Two hours later, these animals received ASC (EAH+ASC group) or PBS vehicle (EAH group). IgG1 and IgG2a were evaluated 8 h, 24 h and 7 d after induction. TGF-β was measured in a splenocyte culture at this last time. The isotype levels in the EAH group were low throughout the kinetics. In the EAH+ASC group, there was significant production of IgG1 at 24 h and 7 d, but of IgG2a only at 7 d. There was statistically greater production of TGF-β in the EAH+ASC group. The higher levels of IgG1 and TGF-β in this group suggest that an additional Th1 response control route exists in EAH, which needs to be investigated.

Treat Autoimmune Hepatitis Based on History

2011 ◽  
Vol 44 (10) ◽  
pp. 26
Author(s):  
SHARON WORCESTER
Keyword(s):  
Autoimmune Hepatitis

High prevalence of autoimmune hepatitis among patients with primary sclerosing cholangitisNote

2000 ◽  
Vol 33 (4) ◽  
pp. 543-548 ◽  
Author(s):  
Henk R. van Buuren ◽  
Hubert J. F. van Hoogstraten ◽  
Turkan Terkivatan ◽  
Solko W. Schalm ◽  
Frank P. Vleggaar
Keyword(s):  
Autoimmune Hepatitis ◽  
High Prevalence
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