scholarly journals Increased Pain Sensitivity in Chronic Pain Subjects on Opioid Therapy: A Cross-Sectional Study Using Quantitative Sensory Testing

Pain Medicine ◽  
2015 ◽  
Vol 16 (5) ◽  
pp. 911-922 ◽  
Author(s):  
Yi Zhang ◽  
Shihab Ahmed ◽  
Trang Vo ◽  
Kristin St. Hilaire ◽  
Mary Houghton ◽  
...  
Diabetes Care ◽  
1997 ◽  
Vol 20 (2) ◽  
pp. 179-181 ◽  
Author(s):  
R. E. Maser ◽  
C. Laudadio ◽  
M. J. Lenhard ◽  
G. S. DeCherney

Physiotherapy ◽  
2019 ◽  
Vol 105 (3) ◽  
pp. 346-353
Author(s):  
Laura M. Mackey ◽  
Catherine Blake ◽  
Maire-Brid Casey ◽  
Camillus K. Power ◽  
Ray Victory ◽  
...  

Pain Medicine ◽  
2021 ◽  
Author(s):  
Michal Rivel ◽  
Anat Achiron ◽  
Mark Dolev ◽  
Yael Stern ◽  
Gaby Zeilig ◽  
...  

Abstract Objective About a third of patients with multiple sclerosis (MS) suffer from chronic and excruciating central neuropathic pain (CNP). The mechanism underlying CNP in MS is not clear, since previous studies are scarce and their results are inconsistent. Our aim was to determine whether CNP in MS is associated with impairment of the spinothalamic-thalamocortical pathways (STTCs) and/or increased excitability of the pain system. Design Cross sectional study Setting General hospital Subjects 47 MS patients with CNP, 42 MS patients without CNP, and 32 healthy controls. Methods Sensory testing included the measurement of temperature, pain, and touch thresholds and the thermal grill illusion (TGI) for evaluating STTCs function, and hyperpathia and allodynia as indicators of hyperexcitability. CNP was characterized using interviews and questionnaires. Results The CNP group had higher cold and warm thresholds (p < 0.01), as well as higher TGI perception thresholds (p < 0.05), especially in painful body regions compared to controls, whereas touch and pain thresholds values were normal. The CNP group also had a significantly greater prevalence of hyperpathia and allodynia. Regression analysis revealed that whereas presence of CNP was associated with a higher cold threshold, CNP intensity, and the number of painful body regions were associated with allodynia and hyperpathia, respectively. Conclusions CNP in MS is characterized by a specific impairment of STTC function; the innocuous thermal pathways, and by pain hyperexcitability. Whereas CNP presence is associated with STTC impairment, its severity and extent are associated with pain hyperexcitability. Interventions that reduce excitability level may therefore mitigate CNP severity.


2015 ◽  
Vol 71 (11) ◽  
pp. 2551-2562 ◽  
Author(s):  
Julia Lukewich ◽  
Elizabeth Mann ◽  
Elizabeth VanDenKerkhof ◽  
Joan Tranmer

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Ashraf El-Metwally ◽  
Quratulain Shaikh ◽  
Abdulrahman Aldiab ◽  
Jamaan Al-Zahrani ◽  
Sameer Al-Ghamdi ◽  
...  

PLoS ONE ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. e0190567 ◽  
Author(s):  
Heidi Johansen ◽  
Trine Bathen ◽  
Liv Øinæs Andersen ◽  
Svend Rand-Hendriksen ◽  
Kristin Østlie

2020 ◽  
Vol 34 (3) ◽  
pp. 107-113
Author(s):  
R. Marcus C. Foo ◽  
Chantal Hoff ◽  
Nitin K. Sekhri ◽  
Garret Weber

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