X-linked inhibitor of apoptosis single nucleotide polymorphisms and copy number variation are not risk factors for asthma

Statin therapy is considered to be safe and rarely associated with serious adverse events. However, a significant proportion of patients on statin therapy show some degree of intolerance which can lead to decreased adherence to statin therapy. The authors summarize the symptoms, signs and frequencies of the most common statin-induced adverse effects and their most important risk factors including some single nucleotide polymorphisms and gene mutations. Also, they review the available approaches to detect and manage the statin-intolerant patients. Orv. Hetil., 2013, 154, 83–92.

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The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease

Human Genetics ◽

10.1007/s00439-018-1910-3 ◽

2018 ◽

Vol 137 (6-7) ◽

pp. 553-567 ◽

Cited By ~ 19

Author(s):

Jiaqi Liu ◽

◽

Yangzhong Zhou ◽

Sen Liu ◽

Xiaofei Song ◽

...

Keyword(s):

Single Nucleotide Polymorphisms ◽

Copy Number ◽

Copy Number Variations ◽

Nucleotide Polymorphisms ◽

Single Nucleotide

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Stability of variable importance scores and rankings using statistical learning tools on single-nucleotide polymorphisms and risk factors involved in gene × gene and gene × environment interactions

BMC Proceedings ◽

10.1186/1753-6561-1-s1-s58 ◽

2007 ◽

Vol 1 (Suppl 1) ◽

pp. S58 ◽

Cited By ~ 7

Author(s):

Kristin K Nicodemus ◽

Wenyi Wang ◽

Yin Shugart

Keyword(s):

Risk Factors ◽

Single Nucleotide Polymorphisms ◽

Statistical Learning ◽

Variable Importance ◽

Nucleotide Polymorphisms ◽

Learning Tools ◽

Single Nucleotide ◽

Gene Environment

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Genetics of Schizophrenia and Bipolar Disorder

10.1093/med/9780190681425.003.0013 ◽

2017 ◽

Author(s):

Alexander Charney ◽

Pamela Sklar

Keyword(s):

Bipolar Disorder ◽

Copy Number ◽

Psychotic Disorders ◽

Copy Number Variants ◽

Nucleotide Polymorphisms ◽

Common Variants ◽

Single Nucleotide Variants ◽

Single Nucleotide ◽

Number Variation

Schizophrenia and bipolar disorder are the classic psychotic disorders. Both diseases are strongly familial, but have proven recalcitrant to genetic methodologies for identifying the etiology until recently. There is now convincing genetic evidence that indicates a contribution of many DNA changes to the risk of becoming ill. For schizophrenia, there are large contributions of rare copy number variants and common single nucleotide variants, with an overall highly polygenic genetic architecture. For bipolar disorder, the role of copy number variation appears to be much less pronounced. Specific common single nucleotide polymorphisms are associated, and there is evidence for polygenicity. Several surprises have emerged from the genetic data that indicate there is significantly more molecular overlap in copy number variants between autism and schizophrenia, and in common variants between schizophrenia and bipolar disorder.

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