Statin-induced adverse effects – facts and genes

2013 ◽  
Vol 154 (3) ◽  
pp. 83-92
Author(s):  
Mariann Harangi ◽  
Noémi Zsíros ◽  
Lilla Juhász ◽  
György Paragh
Keyword(s):  
Risk Factors ◽  
Single Nucleotide Polymorphisms ◽  
Adverse Effects ◽  
Adverse Events ◽  
Statin Therapy ◽  
Significant Proportion ◽  
Gene Mutations ◽  
Nucleotide Polymorphisms ◽  
Serious Adverse Events ◽  
Single Nucleotide

Statin therapy is considered to be safe and rarely associated with serious adverse events. However, a significant proportion of patients on statin therapy show some degree of intolerance which can lead to decreased adherence to statin therapy. The authors summarize the symptoms, signs and frequencies of the most common statin-induced adverse effects and their most important risk factors including some single nucleotide polymorphisms and gene mutations. Also, they review the available approaches to detect and manage the statin-intolerant patients. Orv. Hetil., 2013, 154, 83–92.

scholarly journals Role of six single nucleotide polymorphisms, risk factors in coronary disease, inOLR1alternative splicing

RNA ◽  
2015 ◽  
Vol 21 (6) ◽  
pp. 1187-1202 ◽  
Author(s):  
J. Ramón Tejedor ◽  
Hagen Tilgner ◽  
Camilla Iannone ◽  
Roderic Guigó ◽  
Juan Valcárcel
Keyword(s):  
Risk Factors ◽  
Single Nucleotide Polymorphisms ◽  
Coronary Disease ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

Identification of single nucleotide polymorphisms (SNPs) associated with adverse effects of gefinitib

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 3020-3020
Author(s):  
M. Isomura ◽  
M. Fukuoka ◽  
S. Sone ◽  
M. Matsuura ◽  
T. Noda ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Adverse Effects ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

scholarly journals Variants in the 5α-Reductase Type 1 and Type 2 Genes Are Associated with Polycystic Ovary Syndrome and the Severity of Hirsutism in Affected Women

2006 ◽  
Vol 91 (10) ◽  
pp. 4085-4091 ◽  
Author(s):  
Mark O. Goodarzi ◽  
Nissar A. Shah ◽  
Heath J. Antoine ◽  
Marita Pall ◽  
Xiuqing Guo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Los Angeles ◽  
Single Nucleotide Polymorphisms ◽  
Polycystic Ovary Syndrome ◽  
White Women ◽  
Polycystic Ovary ◽  
Nucleotide Polymorphisms ◽  
Ovary Syndrome ◽  
Single Nucleotide ◽  
Control Subjects

Abstract Context: Despite the importance of dihydrotestosterone in androgen action, polymorphisms in the genes for the two isoforms of 5α-reductase (SRD5A1 and SRD5A2) have not been evaluated as risk factors for polycystic ovary syndrome (PCOS). Objective: The objective of the study was to test the hypothesis that haplotypes in the SRD5A1 and SRD5A2 genes are risk factors for PCOS and the severity of hirsutism in affected women. Design: PCOS and control subjects were genotyped for seven single-nucleotide polymorphisms in SRD5A1 and eight single-nucleotide polymorphisms in SRD5A2. Haplotypes were determined and tested for association with PCOS diagnosis and component phenotypes. Setting: Subjects were recruited from the reproductive endocrinology clinic at the University of Alabama at Birmingham; control subjects were recruited from the general surrounding community. Genotyping took place at Cedars-Sinai Medical Center in Los Angeles. Participants: A total of 287 White women with PCOS and 187 controls participated. Main Measurements: SRD5A1 and SRD5A2 genotype, quantitative hirsutism score, and hormonal and metabolic phenotypes were assessed. Results: Haplotypes within both genes were associated with PCOS risk. The Leu allele of the Val89Leu variant in SRD5A2 was associated with protection against PCOS; this allele is known to modestly reduce 5α-reductase activity. Haplotypes in SRD5A1 but not SRD5A2 were also associated with the degree of hirsutism in affected women. Conclusions: This study presents genetic evidence suggesting an important role of both isoforms of 5α-reductase in the pathogenesis of PCOS. That only SRD5A1 haplotypes were associated with hirsutism suggests that only this isoform is important in the hair follicle.

scholarly journals Use of Single-Nucleotide Polymorphisms and Mammographic Density Plus Classic Risk Factors for Breast Cancer Risk Prediction

JAMA Oncology ◽  
2018 ◽  
Vol 4 (4) ◽  
pp. 476 ◽  
Author(s):  
Elke M. van Veen ◽  
Adam R. Brentnall ◽  
Helen Byers ◽  
Elaine F. Harkness ◽  
Susan M. Astley ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Single Nucleotide Polymorphisms ◽  
Risk Prediction ◽  
Mammographic Density ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide
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