Impacts of high‐intensity exercise on the metabolomics profile of human skeletal muscle tissue

2021 ◽  
Author(s):  
Alessandro M. Zagatto ◽  
David J. Bishop ◽  
Barbara Moura Antunes ◽  
Wladimir R. Beck ◽  
Elvis S. Malta ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Tissue ◽  
High Intensity ◽  
Human Skeletal Muscle ◽  
High Intensity Exercise ◽  
Skeletal Muscle Tissue

3D-bioengineered model of human skeletal muscle tissue with phenotypic features of aging for drug testing purposes

2021 ◽  
Author(s):  
Rafael Mestre ◽  
Nerea García ◽  
Tania Patiño ◽  
Maria Guix ◽  
Judith Fuentes ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Tissue ◽  
Drug Testing ◽  
Human Skeletal Muscle ◽  
Skeletal Muscle Tissue ◽  
Phenotypic Features

scholarly journals Antioxidants Facilitate High–intensity Exercise IL–15 Expression in Skeletal Muscle

2018 ◽  
Vol 40 (01) ◽  
pp. 16-22 ◽  
Author(s):  
Alberto Pérez-López ◽  
Marcos Martin-Rincon ◽  
Alfredo Santana ◽  
Ismael Perez-Suarez ◽  
Cecilia Dorado ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Protein Expression ◽  
High Intensity ◽  
Human Skeletal Muscle ◽  
Vastus Lateralis ◽  
Acute Hypoxia ◽  
High Intensity Exercise ◽  
Oxygen Deficit ◽  
Post Exercise ◽  
Sprint Exercise

AbstractInterleukin (IL)-15 stimulates mitochondrial biogenesis, fat oxidation, glucose uptake and myogenesis in skeletal muscle. However, the mechanisms by which exercise triggers IL-15 expression remain to be elucidated in humans. This study aimed at determining whether high-intensity exercise and exercise-induced RONS stimulate IL-15/IL-15Rα expression and its signaling pathway (STAT3) in human skeletal muscle. Nine volunteers performed a 30-s Wingate test in normoxia and hypoxia (PIO2=75 mmHg), 2 h after placebo or antioxidant administration (α-lipoic acid, vitamin C and E) in a randomized double-blind design. Blood samples and muscle biopsies (vastus lateralis) were obtained before, immediately after, and 30 and 120 min post-exercise. Sprint exercise upregulated skeletal muscle IL-15 protein expression (ANOVA, P=0.05), an effect accentuated by antioxidant administration in hypoxia (ANOVA, P=0.022). In antioxidant conditions, the increased IL-15 expression at 120 min post-exercise (33%; P=0.017) was associated with the oxygen deficit caused by the sprint (r=–0.54; P=0.020); while, IL-15 and Tyr705-STAT3 AUCs were also related (r=0.50; P=0.036). Antioxidant administration promotes IL-15 protein expression in human skeletal muscle after sprint exercise, particularly in severe acute hypoxia. Therefore, during intense muscle contraction, a reduced PO2 and glycolytic rate, and possibly, an attenuated RONS generation may facilitate IL-15 production, accompanied by STAT3 activation, in a process that does not require AMPK phosphorylation.

Effect of short-term, high-intensity exercise training on human skeletal muscle citrate synthase maximal activity: single versus multiple bouts per session

2019 ◽  
Vol 44 (12) ◽  
pp. 1391-1394
Author(s):  
Martin J. MacInnis ◽  
Lauren E. Skelly ◽  
F. Elizabeth Godkin ◽  
Brian J. Martin ◽  
Thomas R. Tripp ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Exercise Training ◽  
High Intensity ◽  
Human Skeletal Muscle ◽  
Citrate Synthase ◽  
Vastus Lateralis ◽  
Maximal Activity ◽  
High Intensity Exercise ◽  
Short Term ◽  
Significant Difference

The legs of 9 men (age 21 ± 2 years, 45 ± 4 mL/(kg·min)) were randomly assigned to complete 6 sessions of high-intensity exercise training, involving either one or four 5-min bouts of counterweighted, single-leg cycling. Needle biopsies from vastus lateralis revealed that citrate synthase maximal activity increased after training in the 4-bout group (p = 0.035) but not the 1-bout group (p = 0.10), with a significant difference between groups post-training (13%, p = 0.021). Novelty Short-term training using brief intense exercise requires multiple bouts per session to increase mitochondrial content in human skeletal muscle.

Comparing time-resolved and continuous-wave near-infrared spectroscopy for determining oxygen saturation in human skeletal muscle tissue

2016 ◽  
Author(s):  
Emilie Krite Svanberg ◽  
Alfi Shaharin ◽  
Ida Ellerström ◽  
Arman Ahamed Subash ◽  
Dmitry Khoptyar ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Infrared Spectroscopy ◽  
Oxygen Saturation ◽  
Muscle Tissue ◽  
Near Infrared Spectroscopy ◽  
Human Skeletal Muscle ◽  
Near Infrared ◽  
Continuous Wave ◽  
Skeletal Muscle Tissue ◽  
Time Resolved

Expression of both oestrogen receptor alpha and beta in human skeletal muscle tissue

2008 ◽  
Vol 131 (2) ◽  
pp. 181-189 ◽  
Author(s):  
A. Wiik ◽  
M. Ekman ◽  
O. Johansson ◽  
E. Jansson ◽  
M. Esbjörnsson
Keyword(s):  
Skeletal Muscle ◽  
Muscle Tissue ◽  
Oestrogen Receptor ◽  
Human Skeletal Muscle ◽  
Skeletal Muscle Tissue ◽  
Receptor Alpha ◽  
Oestrogen Receptor Alpha

The response of human skeletal muscle tissue to hypoxia

2009 ◽  
Vol 66 (22) ◽  
pp. 3615-3623 ◽  
Author(s):  
Carsten Lundby ◽  
Jose A. L. Calbet ◽  
Paul Robach
Keyword(s):  
Skeletal Muscle ◽  
Muscle Tissue ◽  
Human Skeletal Muscle ◽  
Skeletal Muscle Tissue
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