scholarly journals System level analysis of cacao seed ripening reveals a sequential interplay of primary and secondary metabolism leading to polyphenol accumulation and preparation of stress resistance

2016 ◽  
Vol 87 (3) ◽  
pp. 318-332 ◽  
Author(s):  
Lei Wang ◽  
Thomas Nägele ◽  
Hannes Doerfler ◽  
Lena Fragner ◽  
Palak Chaturvedi ◽  
...  
Keyword(s):  
Secondary Metabolism ◽  
Stress Resistance ◽  
System Level ◽  
Primary And Secondary Metabolism ◽  
Level Analysis

scholarly journals Genome-Scale Reconstruction of Microbial Dynamic Phenotype: Successes and Challenges

2021 ◽  
Vol 9 (11) ◽  
pp. 2352
Author(s):  
Nicolai Panikov
Keyword(s):  
Growth Rate ◽  
Secondary Metabolism ◽  
Stress Responses ◽  
Stress Resistance ◽  
Environmental Conditions ◽  
The Real ◽  
Cell Composition ◽  
Primary And Secondary Metabolism ◽  
Conditional Expression ◽  
Genome Scale

This review is a part of the SI ‘Genome-Scale Modeling of Microorganisms in the Real World’. The goal of GEM is the accurate prediction of the phenotype from its respective genotype under specified environmental conditions. This review focuses on the dynamic phenotype; prediction of the real-life behaviors of microorganisms, such as cell proliferation, dormancy, and mortality; balanced and unbalanced growth; steady-state and transient processes; primary and secondary metabolism; stress responses; etc. Constraint-based metabolic reconstructions were successfully started two decades ago as FBA, followed by more advanced models, but this review starts from the earlier nongenomic predecessors to show that some GEMs inherited the outdated biokinetic frameworks compromising their performances. The most essential deficiencies are: (i) an inadequate account of environmental conditions, such as various degrees of nutrients limitation and other factors shaping phenotypes; (ii) a failure to simulate the adaptive changes of MMCC (MacroMolecular Cell Composition) in response to the fluctuating environment; (iii) the misinterpretation of the SGR (Specific Growth Rate) as either a fixed constant parameter of the model or independent factor affecting the conditional expression of macromolecules; (iv) neglecting stress resistance as an important objective function; and (v) inefficient experimental verification of GEM against simple growth (constant MMCC and SGR) data. Finally, we propose several ways to improve GEMs, such as replacing the outdated Monod equation with the SCM (Synthetic Chemostat Model) that establishes the quantitative relationships between primary and secondary metabolism, growth rate and stress resistance, process kinetics, and cell composition.

Pravastatin: A tool for investigating the availability of mevalonate metabolites for primary and secondary metabolism in Catharanthus roseus cell suspensions

1996 ◽  
Vol 98 (4) ◽  
pp. 803-809 ◽  
Author(s):  
Nadine Imbault ◽  
Martine Thiersault ◽  
Paulette Duperon ◽  
Abdellah Benabdelmouna ◽  
Pierre Doireau
Keyword(s):  
Secondary Metabolism ◽  
Catharanthus Roseus ◽  
Cell Suspensions ◽  
Primary And Secondary Metabolism

Application of AI-based techniques for system-level analysis of Space Station Freedom

1991 ◽  
Author(s):  
KENNETH LASKEY ◽  
ALFRED KROMHOLZ
Keyword(s):  
Space Station ◽  
System Level ◽  
Space Station Freedom ◽  
Level Analysis

scholarly journals A system-level analysis model for lunar calibration of multispectral payload on remote sensing satellites

2020 ◽  
Vol 514 ◽  
pp. 022031
Author(s):  
Chi Xu ◽  
Tao He ◽  
Jin Huang ◽  
Fang Ren
Keyword(s):  
Remote Sensing ◽  
System Level ◽  
Analysis Model ◽  
Level Analysis

scholarly journals Metabolite profiling during graft union formation reveals the reprogramming of primary metabolism and the induction of stilbene synthesis at the graft interface in grapevine

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Duyên Prodhomme ◽  
Josep Valls Fonayet ◽  
Cyril Hévin ◽  
Céline Franc ◽  
Ghislaine Hilbert ◽  
...  
Keyword(s):  
Amino Acids ◽  
Secondary Metabolism ◽  
Fruits And Vegetables ◽  
Cell Formation ◽  
Union Formation ◽  
Primary Metabolism ◽  
Graft Union ◽  
Primary And Secondary Metabolites ◽  
Primary And Secondary Metabolism ◽  
Graft Interface

Abstract Background Grafting with rootstocks is essential for the culture of many perennial fruit crops and is increasing being used in the production of annual fruits and vegetables. Our previous work based on microarrays showed that transcripts encoding enzymes of both primary and secondary metabolism were differentially expressed during graft union formation in both homo-grafts (a genotype grafted with itself) and hetero-grafts (two different genotypes grafted together). The aim of this study was to profile primary and secondary metabolites, and quantify the activity of phenylalanine ammonia lyase (PAL) and neutral invertase (NI) in the scion and rootstock tissues and the graft interface of homo and hetero-grafts of grapevine 1 month after grafting. Table-top grafting was done on over-wintering stems (canes) of grapevine and the graft interface tissues (containing some woody stem tissues and callus) were compared to the surrounding rootstock and scion tissues. The objective was to identify compounds involved in graft union formation and hetero-grafting responses. Results A total of 54 compounds from primary and secondary metabolism (19 amino acids, five primary and 30 secondary compounds metabolites) and the activity of two enzymes were measured. The graft interface was associated with an increase in the accumulation of the branched-chain amino acids, basic amino acids, certain stilbene compounds and higher PAL and NI activity in comparison to the surrounding woody stem tissues. Some amino acids and stilbenes were identified as being accumulated differently between the graft interfaces of the scion/rootstock combinations in a manner which was unrelated to their concentrations in the surrounding woody stem tissues. Conclusions This study revealed the modification of primary metabolism to support callus cell formation and the stimulation of stilbene synthesis at the graft interface, and how these processes are modified by hetero-grafting. Knowledge of the metabolites and/or enzymes required for successful graft union formation offer us the potential to identify markers that could be used by nurseries and researchers for selection and breeding purposes.

scholarly journals Control of sulfur partitioning between primary and secondary metabolism in Arabidopsis

2012 ◽  
Vol 3 ◽  
Author(s):  
Stanislav Kopriva ◽  
Sarah G. Mugford ◽  
Patrycja Baraniecka ◽  
Bok-Rye Lee ◽  
Colette A. Matthewman ◽  
...  
Keyword(s):  
Secondary Metabolism ◽  
Primary And Secondary Metabolism

Simple large-signal model based on gyrator for system level analysis

2011 ◽  
Author(s):  
Weijing Du ◽  
Yang Zhang ◽  
Junming Zhang ◽  
Zhaoming Qian
Keyword(s):  
System Level ◽  
Large Signal ◽  
Signal Model ◽  
Model Based ◽  
Level Analysis

On-Site Renewable Energy and Green Buildings: A System-Level Analysis

2016 ◽  
Vol 50 (9) ◽  
pp. 4606-4614 ◽  
Author(s):  
Sami G. Al-Ghamdi ◽  
Melissa M. Bilec
Keyword(s):  
Renewable Energy ◽  
Green Buildings ◽  
System Level ◽  
Level Analysis
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