scholarly journals COVID ‐19 convalescent plasma donor recruitment: beware the Faustian bargains

Transfusion ◽  
2020 ◽  
Vol 60 (7) ◽  
pp. 1643-1644 ◽  
Author(s):  
Thomas J. Gniadek ◽  
David Donnersberger
Transfusion ◽  
2021 ◽  
Author(s):  
Jenna Wade ◽  
Edward A. Dent ◽  
Melanie S. Wooten ◽  
Mitchell Moosavi ◽  
Hailly Butler ◽  
...  

2021 ◽  
Author(s):  
Durba Biswas ◽  
Chikam Maiti ◽  
Biplabendu Talukder ◽  
Md Azharuddin ◽  
Sayantan Saha ◽  
...  

Author(s):  
Joanna Balcerek ◽  
Evelin Trejo ◽  
Kendall Levine ◽  
Paul Couey ◽  
Zoe V Kornberg ◽  
...  

Abstract Objectives Serologic testing for antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in potential donors of coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) may not be performed until after blood donation. A hospital-based recruitment program for CCP may be an efficient way to identify potential donors prospectively Methods Patients who recovered from known or suspected COVID-19 were identified and recruited through medical record searches and public appeals in March and April 2020. Participants were screened with a modified donor history questionnaire and, if eligible, were asked for consent and tested for SARS-CoV-2 antibodies (IgG and IgM). Participants positive for SARS-CoV-2 IgG were referred for CCP collection. Results Of 179 patients screened, 128 completed serologic testing and 89 were referred for CCP donation. IgG antibodies to SARS-CoV-2 were detected in 23 of 51 participants with suspected COVID-19 and 66 of 77 participants with self-reported COVID-19 confirmed by polymerase chain reaction (PCR). The anti–SARS-CoV-2 IgG level met the US Food and Drug Administration criteria for “high-titer” CCP in 39% of participants confirmed by PCR, as measured by the Ortho VITROS IgG assay. A wide range of SARS-CoV-2 IgG levels were observed. Conclusions A hospital-based CCP donor recruitment program can prospectively identify potential CCP donors. Variability in SARS-CoV-2 IgG levels has implications for the selection of CCP units for transfusion.


2016 ◽  
Vol 14 (5) ◽  
pp. 609-617 ◽  
Author(s):  
Katherine M. Prioli ◽  
◽  
Laura T. Pizzi ◽  
Julie Katz Karp ◽  
Taki Galanis ◽  
...  
Keyword(s):  

Transfusion ◽  
2003 ◽  
Vol 43 (1) ◽  
pp. 7-16 ◽  
Author(s):  
Simone A. Glynn ◽  
Alan E. Williams ◽  
Catharie C. Nass ◽  
James Bethel ◽  
Debra Kessler ◽  
...  

Author(s):  
N.S. Vildanova ◽  
E.S. Kormshchikova ◽  
E.V. Butina ◽  
E.A. Poponina ◽  
A.V. Yovdiy ◽  
...  
Keyword(s):  

2013 ◽  
Vol 3 (5) ◽  
pp. 390-393 ◽  
Author(s):  
SR Kandel ◽  
P Ghimire ◽  
BR Tiwari ◽  
M Rajkarnikar

Background: HIV and Hepatitis B infections are public health problems in Nepal. This study was conducted based at NRCS/CBTS, with the objective of determining the HIV and HBsAg sero-prevalence in non-remunerated volunteer blood donors. Materials and Methods: A total of 66,904 units of blood collected, following donor recruitment criteriaduring March 2009-Sept. 2010 was included for analysis. All donated blood samples were subjected to screening for Transfusion transmitted infections including HIV and Hepatitis B surface antigen using standard ELISA test kits (Dade Behring, Germany). Initial reactive sera were re-tested for reconfi rmation with same test kits plus another test kit (Detect-HIV, Adaltis Inc, and Qualisa). Results: Out of 66,904 units of blood collected, 56,973 units were from male and 9,931 were from female donors. Among the total screened samples, 73 (0.10%) were found to be positive for HIV, {0.11% (64/56973) in male and 0.09% (9/9931) in female}; the difference between male and female donors (?2<3.841) was statistically signifi cant. The seroprevalence of HIV was highest in age group of 30- 39 both in male and female (p<0.001). Similarly, for HBsAg, overall seroprevalence was found to be 0.47% (316/66904 {0.42% (242/56973) in male and 0.74% (74/9931) in female}. The difference was statistically signifi cant (?2<3.841). The highest HBsAg sero-prevalence(0.65%) was also observed in same age group i.e. 30-39 (p<0.001) in male but highest seroprevalence (2.63%) was observed inage group of ?50 in female. Conclusion: Both HIV and HBV sero-prevalence is high in adult voluntary blood donors. Journal of Pathology of Nepal (2013) Vol. 3, No.1, Issue 5, 390-393 DOI: http://dx.doi.org/10.3126/jpn.v3i5.7864


2017 ◽  
Vol 78 ◽  
pp. 63
Author(s):  
Yuxin Yin ◽  
Ping Takemura ◽  
Yung-Tsi Bolon ◽  
Brianna Springer ◽  
Katsuyuki Saito ◽  
...  

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