scholarly journals Anti‐D alloimmunization in Rh(D) negative adults with severe traumatic injury

Transfusion ◽  
2021 ◽  
Vol 61 (S1) ◽  
Author(s):  
Jay S. Raval ◽  
Kathleen M. Madden ◽  
Matthew D. Neal ◽  
Sarah A. Moore
Keyword(s):  
Traumatic Injury ◽  
Severe Traumatic Injury

Ketamine in Severe Traumatic Injury

2020 ◽  
Author(s):  
Keyword(s):  
Traumatic Injury ◽  
Severe Traumatic Injury

scholarly journals The Histopathology of Severe Graded Compression in Lower Thoracic Spinal Cord Segment of Rat, Evaluated at Late Post-injury Phase

2021 ◽  
Author(s):  
Fedorova Jana ◽  
Kellerova Erika ◽  
Bimbova Katarina ◽  
Pavel Jaroslav
Keyword(s):  
Spinal Cord ◽  
Spontaneous Recovery ◽  
Traumatic Injury ◽  
Blue Dye ◽  
Post Injury ◽  
Thoracic Spinal Cord ◽  
Thoracic Spinal ◽  
Severe Traumatic Injury ◽  
Spinal Cord Segment ◽  
Cord Injury

AbstractSpontaneous recovery of lost motor functions is relative fast in rodent models after inducing a very mild/moderate spinal cord injury (SCI), and this may complicate a reliable evaluation of the effectiveness of potential therapy. Therefore, a severe graded (30 g, 40 g and 50 g) weight-compression SCI at the Th9 spinal segment, involving an acute mechanical impact followed by 15 min of persistent compression, was studied in adult female Wistar rats. Functional parameters, such as spontaneous recovery of motor hind limb and bladder emptying function, and the presence of hematuria were evaluated within 28 days of the post-traumatic period. The disruption of the blood-spinal cord barrier, measured by extravasated Evans Blue dye, was examined 24 h after the SCI, when maximum permeability occurs. At the end of the survival period, the degradation of gray and white matter associated with the formation of cystic cavities, and quantitative changes of glial structural proteins, such as GFAP, and integral components of axonal architecture, such as neurofilaments and myelin basic protein, were evaluated in the lesioned area of the spinal cord. Based on these functional and histological parameters, and taking the animal’s welfare into account, the 40 g weight can be considered as an upper limit for severe traumatic injury in this compression model.

scholarly journals Full circumference lower extremity degloving injury treated with hydrosurgical debridement and negative-pressure wound therapy with gauze wound filler for fixation of avulsed flap skin grafts

2020 ◽  
Vol 2020 (12) ◽  
Author(s):  
Tae Nagama ◽  
Natsuko Kakudo ◽  
Atsuyuki Kuro ◽  
Yujiro Ozaki ◽  
Yasuko Shirasawa ◽  
...  
Keyword(s):  
Lower Extremity ◽  
Negative Pressure ◽  
Negative Pressure Wound Therapy ◽  
Traumatic Injury ◽  
Skin Grafts ◽  
Wound Therapy ◽  
Left Lower Extremity ◽  
Degloving Injury ◽  
Severe Traumatic Injury ◽  
Degloving Injuries

Abstract Degloving, a skin and subcutis avulsion, is a severe traumatic injury sometimes caused by rolling wheels or machines. Although avulsed flaps are often readapted to its original site, most of these tissues become necrotic. Due to the extensive skin and soft tissue deficiency caused by necrosis, treatment becomes difficult. Skin grafts harvested from avulsed flaps may be used to treat degloving injuries, while negative pressure wound therapy (NPWT) is used to secure the grafts. Commonly used porous polyurethane foam wound fillers are difficult to set in circumferential extremity degloving injuries; gauze-based wound fillers are easier to use and cause less pain during dressing changes. We present a case of an extensive, full-circumference left lower-extremity degloving injury, treated using NPWT with gauze-based wound fillers for fixation of skin grafts harvested from avulsed flaps after hydrosurgical debridement. For complex wound geometries, gauze-based wound fillers can be easily applied for skin graft immobilization.

An Extended First Dorsal Metacarpal Artery Neurovascular Island Flap

1995 ◽  
Vol 20 (4) ◽  
pp. 529-531 ◽  
Author(s):  
B. GEBHARD ◽  
G. MEISSL
Keyword(s):  
Traumatic Injury ◽  
Island Flap ◽  
Severe Traumatic Injury ◽  
Dorsal Metacarpal Artery ◽  
First Dorsal Metacarpal Artery

A case of severe traumatic injury to the thumb treated by an extended variation of the first dorsal metacarpal artery neurovascular pedicled island flap is reported.

scholarly journals Severe trauma in young permanent tooth: a case report

2020 ◽  
Vol 68 ◽  
Author(s):  
Ana Luiza Costa Silva de OMENA ◽  
Ivana Aguiar FERREIRA ◽  
Claudia Lima RAMAGEM ◽  
Kelly Maria Silva MOREIRA ◽  
Isabela FLORIANO ◽  
...  
Keyword(s):  
Alveolar Bone ◽  
Root Resorption ◽  
Traumatic Injury ◽  
Severe Trauma ◽  
Permanent Tooth ◽  
Dental Office ◽  
Severe Traumatic Injury ◽  
Dentoalveolar Trauma ◽  
To Receive

ABSTRACT Dentoalveolar trauma is a severe traumatic injury involving alveolar bone and dental structures. Like any trauma, it can leave irreparable sequelae and even cause tooth loss. The aim of this study is to report on the case of a dentoalveolar trauma in a 10-year-old male patient and the treatment performed with 12-month follow-up. The child had lateral luxation and displacement of teeth 11 and 21 in labial direction after a fall from his own height. The patient was examined at a hospital, received medication and was referred to a dental clinic. At the dental office, the teeth were repositioned, as well as received endodontic treatment and dental reanatomization. Two months after the trauma, root resorption was observed externally, which remained stable for 12 months. It was concluded that post-trauma treatment should be immediate and that follow-up sessions should be done carefully to minimize sequelae and to receive better prognosis.

scholarly journals Severe Traumatic Injury Induces Phenotypic and Functional Changes of Neutrophils and Monocytes

2021 ◽  
Vol 10 (18) ◽  
pp. 4139
Author(s):  
Andrea Janicova ◽  
Nils Becker ◽  
Baolin Xu ◽  
Marija Simic ◽  
Laurens Noack ◽  
...  
Keyword(s):  
Immune Response ◽  
Traumatic Injury ◽  
Physiological Role ◽  
Blood Analysis ◽  
Intermediate Phenotype ◽  
Ros Generation ◽  
Monocyte Subsets ◽  
Phagocytic Capacity ◽  
Functional Changes ◽  
Severe Traumatic Injury

Background: Severe traumatic injury has been associated with high susceptibility for the development of secondary complications caused by dysbalanced immune response. As the first line of the cellular immune response, neutrophils and monocytes recruited to the site of tissue damage and/or infection, are divided into three different subsets according to their CD16/CD62L and CD16/CD14 expression, respectively. Their differential functions have not yet been clearly understood. Thus, we evaluated the phenotypic changes of neutrophil and monocyte subsets among their functionality regarding oxidative burst and the phagocytic capacity in severely traumatized patients. Methods: Peripheral blood was withdrawn from severely injured trauma patients (TP; n = 15, ISS ≥ 16) within the first 12 h post-trauma and from healthy volunteers (HV; n = 15) and stimulated with fMLP and PMA. CD16dimCD62Lbright (immature), CD16brightCD62Lbright (mature) and CD16brightCD62Ldim (CD62Llow) neutrophil subsets and CD14brightCD16− (classical), CD14brightCD16+ (intermediate) and CD14dimCD16+ (non-classical) monocyte subsets of HV and TP were either directly analyzed by flow cytometry or the examined subsets of HV were sorted first by fluorescence-activated cell sorting and subsequently analyzed. Subset-specific generation of reactive oxygen species (ROS) and of E. coli bioparticle phagocytosis were evaluated. Results: In TP, the counts of immature neutrophils were significantly increased vs. HV. The numbers of mature and CD62Ldim neutrophils remained unchanged but the production of ROS was significantly enhanced in TP vs. HV and the stimulation with fMLP significantly increased the generation of ROS in the mature and CD62Ldim neutrophils of HV. The counts of phagocyting neutrophils did not change but the mean phagocytic capacity showed an increasing trend in TP. In TP, the monocytes shifted toward the intermediate phenotype, whereas the classical and non-classical monocytes became less abundant. ROS generation was significantly increased in all monocyte subsets in TP vs. HV and PMA stimulation significantly increased those level in both, HV and TP. However, the PMA-induced mean ROS generation was significantly lower in intermediate monocytes of TP vs. HV. Sorting of monocyte and neutrophil subsets revealed a significant increase of ROS and decrease of phagocytic capacity vs. whole blood analysis. Conclusions: Neutrophils and monocytes display a phenotypic shift following severe injury. The increased functional abnormalities of certain subsets may contribute to the dysbalanced immune response and attenuate the antimicrobial function and thus, may represent a potential therapeutic target. Further studies on isolated subsets are necessary for evaluation of their physiological role after severe traumatic injury.

scholarly journals Four Subgroups of Blood Stasis Syndrome Are Identified by Manifestation Cluster Analysis in Males

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Sooseong You ◽  
Byoung-Kab Kang ◽  
Jihyun Kim ◽  
Hoyoung Lee ◽  
Eun Hyoung Shim ◽  
...  
Keyword(s):  
Cluster Analysis ◽  
Pathological Condition ◽  
Traumatic Injury ◽  
Blood Stasis ◽  
Biological Characteristics ◽  
Blood Stasis Syndrome ◽  
Inflammatory Conditions ◽  
East Asian Medicine ◽  
Severe Traumatic Injury ◽  
Inflammatory State

Blood stasis syndrome (BSS) is an important pathological condition in traditional East Asian medicine and is associated with ischemic heart disease, cerebral vascular accident, diabetes mellitus, chronic renal failure, severe traumatic injury, and dysmenorrhea. However, previous studies have been unable to reveal the clinical and biological characteristics or biological markers of BSS. We hypothesized that the heterogeneity among the manifestations of BSS or non-BSS could interfere with an analysis to describe the characteristics of BSS. In this study, male participants based on the severity of BSS-associated symptoms and signs were clustered and classified into four subgroups: BSS subgroups (1), (2), (3), and (4). Non-BSS core subgroup was redefined using manifestation cluster analysis. Biological characteristics of subgroups BSS(1) and BSS(2) belong to the range of the non-BSS core subgroup (1), whereas that of subgroups BSS(3) and BSS(4) are characterized by different biological parameters such as systemic inflammatory conditions and elevated D-dimer level. Our results suggested that patients in subgroups of BSS(3) and BSS(4) are more likely to be exposed in an inflammatory state than other BSS subgroups. We found the heterogeneity among the manifestations which could mask the characteristics of BSS and identified the clinical and biological profiles of the four BSS subgroups through comparisons of the redefined non-BSS and BSS subgroups. This finding could provide accurate diagnostic criteria and new approaches for BSS treatments in different subgroups.

Nosocomial Infection Following Severe Traumatic Injury in Children

2020 ◽  
Vol 21 (5) ◽  
pp. 443-450
Author(s):  
Eric A. Sribnick ◽  
Josey Hensley ◽  
Melissa Moore-Clingenpeel ◽  
Jennifer A. Muszynski ◽  
Rajan K. Thakkar ◽  
...  
Keyword(s):  
Nosocomial Infection ◽  
Traumatic Injury ◽  
Severe Traumatic Injury

Reduced expression of neutrophil CD11b and CD16 after severe traumatic injury

1992 ◽  
Vol 52 (1) ◽  
pp. 22-26 ◽  
Author(s):  
Cathy White-Owen ◽  
J.Wesley Alexander ◽  
George F. Babcock
Keyword(s):  
Traumatic Injury ◽  
Severe Traumatic Injury

89 PROLONGED SURVIVAL FOLLOWING SEVERE TRAUMATIC INJURY LIMITED TO THE BRAIN STEM

1984 ◽  
Vol 43 (3) ◽  
pp. 322
Author(s):  
R. C. Kim ◽  
K. Fagin ◽  
B. H. Choi
Keyword(s):  
Brain Stem ◽  
Traumatic Injury ◽  
Prolonged Survival ◽  
Severe Traumatic Injury ◽  
The Brain
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