Prognostic value of enzymatic liver function for the estimation of short-term survival of liver transplant candidates: a prospective study with the LiMAx test

Background: Long-term survival and functional outcomes should influence admission decisions to intensive care, especially for patients with advanced disease. Aim: To determine whether physicians’ predictions of long-term prognosis influenced admission decisions for patients with and without advanced disease. Design: A prospective study was conducted. Physicians estimated patient survival with intensive care and with care on the ward, and the probability of 4 long-term outcomes: leaving hospital alive, survival at 6 months, recovery of functional status, and recovery of cognitive status. Patient mortality at 28 days was recorded. We built multivariate logistic regression models using admission to the intensive care unit (ICU) as the dependent variable. Setting/participants: ICU consultations for medical inpatients at a Swiss tertiary care hospital were included. Results: Of 201 evaluated patients, 105 (52.2%) had an advanced disease and 140 (69.7%) were admitted to the ICU. The probability of admission was strongly associated with the expected short-term survival benefit for patients with or without advanced disease. In contrast, the predicted likelihood that the patient would leave the hospital alive, would be alive 6 months later, would recover functional status, and would recover initial cognitive capacity was not associated with the decision to admit a patient to the ICU. Even for patients with advanced disease, none of these estimated outcomes influenced the admission decision. Conclusions: ICU admissions of patients with advanced disease were determined by short-term survival benefit, and not by long-term prognosis. Advance care planning and developing decision-aid tools for triage could help limit potentially inappropriate admissions to intensive care.

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Association between Growth Hormone and Insulin-like Growth Factor-1 (IGF-1) Levels, Liver Function and Short-Term Survival of Paediatric Liver Recipients

Russian Journal of Gastroenterology Hepatology Coloproctology ◽

10.22416/1382-4376-2020-30-4-44-51 ◽

2020 ◽

Vol 30 (4) ◽

pp. 44-51

Author(s):

R. M. Kurabekova ◽

O. M. Tsiroulnikova ◽

I. E. Pashkova ◽

L. V. Makarova ◽

N. P. Mozheiko ◽

...

Keyword(s):

Growth Hormone ◽

Growth Factor ◽

Liver Function ◽

Insulin Like Growth Factor ◽

Short Term ◽

Term Survival ◽

Short Term Survival

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Delisting of liver transplant candidates following recompensation of chronic liver diseases – patient characteristics and predictors of delisting: a prospective study

Russian Journal of Transplantology and Artificial Organs ◽

10.15825/1995-1191-2019-4-26-35 ◽

2020 ◽

Vol 21 (4) ◽

pp. 26-35

Author(s):

V. L. Korobka ◽

V. D. Pasechnikov ◽

E. S. Pak ◽

M. Y. Kostrykin ◽

A. V. Tkachev ◽

...

Keyword(s):

Prospective Study ◽

Liver Transplant ◽

Liver Diseases ◽

Patient Characteristics ◽

Chronic Liver ◽

Chronic Liver Diseases ◽

Transplant Candidates ◽

A Prospective Study

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Sa1936 CHALLENGES AND SUCCESS OF INTRAGASTRIC BALLOON THERAPY IN LIVER TRANSPLANT CANDIDATES: A PROSPECTIVE STUDY WITH LONG-TERM FOLLOW-UP

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2020.03.1281 ◽

2020 ◽

Vol 91 (6) ◽

pp. AB211-AB212

Author(s):

Veeravich Jaruvongvanich ◽

Julie Heimbach ◽

Monika Rizk ◽

William Sanchez ◽

John D. Port ◽

...

Keyword(s):

Prospective Study ◽

Liver Transplant ◽

Intragastric Balloon ◽

Long Term Follow Up ◽

Transplant Candidates ◽

A Prospective Study

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A Study on the Clinico-etiological Profile of Cirrhosis of the Liver and Prognostic Value of the MELD Score on Short-term Survival

Bengal Physician Journal ◽

10.5005/jp-journals-10070-7044 ◽

2020 ◽

Vol 7 (3) ◽

pp. 57-59

Author(s):

Atanu Chandra ◽

Gouri S Mahapatra ◽

Koustav A Shah ◽

Mrinal K Roy

Keyword(s):

Prognostic Value ◽

Meld Score ◽

Cirrhosis Of The Liver ◽

Short Term ◽

Term Survival ◽

Short Term Survival

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Prognostic value of paranasopharyngeal extension of nasopharyngeal carcinoma on local control and short-term survival

Head & Neck ◽

10.1002/hed.2880130406 ◽

1991 ◽

Vol 13 (4) ◽

pp. 298-310 ◽

Cited By ~ 73

Author(s):

Jonathan S. T. Sham ◽

D. Choy

Keyword(s):

Nasopharyngeal Carcinoma ◽

Local Control ◽

Prognostic Value ◽

Short Term ◽

Term Survival ◽

Short Term Survival

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The Danish comorbidity in liver transplant recipients study (DACOLT): a non-interventional prospective observational cohort study

BMC Gastroenterology ◽

10.1186/s12876-021-01733-5 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Magda Teresa Thomsen ◽

Julie Høgh ◽

Andreas Dehlbæk Knudsen ◽

Anne Marie Reimer Jensen ◽

Marco Gelpi ◽

...

Keyword(s):

Risk Factors ◽

Liver Transplant ◽

Transplant Recipients ◽

Short Term ◽

Term Survival ◽

Blood Samples ◽

Liver Transplant Recipients ◽

Short Term Survival

Abstract Background Liver transplantation is the only curative treatment for patients with end-stage liver disease. Short-term survival has improved due to improved surgical techniques and greater efficacy of immunosuppressive drugs. However, long-term survival has not improved to the same extent as the short-term survival, and the 10-year survival after liver transplantation is 60%. In addition to liver- and transplant-related causes, comorbidities such as cardiovascular, pulmonary, renal, and metabolic diseases have emerged as leading causes of morbidity and mortality in liver transplant recipients. The objective of this study is to assess the burden of comorbidities and identify both liver- and transplant-related risk factors as well as traditional risk factors that contribute to the pathogenesis of comorbidity in liver transplant recipients. Methods/design The Danish Comorbidity in Liver Transplant Recipients (DACOLT) study is an observational, longitudinal study. We aim to include all adult liver transplant recipients in Denmark (n = approx. 600). Participants will be matched by sex and age to controls from the Copenhagen General Population Study (CGPS) and the Copenhagen City Heart Study (CCHS). Physical and biological measures including blood pressure, ankle–brachial index, spirometry, exhaled nitric oxide, electrocardiogram, transthoracic echocardiography, computed tomography (CT) angiography of the heart, unenhanced CT of chest and abdomen and blood samples will be collected using uniform protocols in participants in DACOLT, CGPS, and CCHS. Blood samples will be collected and stored in a research biobank. Follow-up examinations at regular intervals up to 10 years of follow-up are planned. Discussion There is no international consensus standard for optimal clinical care or monitoring of liver transplant recipients. This study will determine prevalence, incidence and risk factors for comorbidity in liver transplant recipients and may be used to provide evidence for guidelines on management, treatment and screening and thereby contribute to improvement of the long-term survival. Trial registration ClinicalTrials.gov: NCT04777032; date of registration: March 02, 2021.

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CT findings and the prognostic value of the Koret CT score in cats with traumatic brain injury

Journal of Feline Medicine and Surgery ◽

10.1177/1098612x211005306 ◽

2021 ◽

pp. 1098612X2110053

Author(s):

Ohad Mann ◽

Dana Peery ◽

Ronnie Bader Segev ◽

Sigal Klainbart ◽

Efrat Kelmer ◽

...

Keyword(s):

Prognostic Value ◽

Intracranial Haemorrhage ◽

Ct Scans ◽

Short Term ◽

Term Survival ◽

Long Term Survival ◽

Head Ct ◽

Ct Findings ◽

Short Term Survival

Objectives The aims of this study were to evaluate associations between abnormal head CT findings and outcome, and to examine the prognostic value of the Koret CT score (KCTS) in cats sustaining acute traumatic brain injury (TBI). Methods The medical records of cats hospitalised with TBI that underwent head CT scans within 72 h of admission were retrospectively reviewed. CT scans were evaluated independently by a radiologist and a neurologist who were blinded to the outcome. A KCTS and modified Glasgow Coma Scale (MGCS) were assigned to each cat and the association between abnormal CT findings, KCTS, MGCS and outcome were analysed. Results Fourteen cats were included in the study: nine (64.2%) survivors and five (35.7%) non-survivors. Of the nine cats that were discharged, one was a short-term survivor (10 days) and eight (57.1%) were long-term survivors (⩾6 months). Abnormal CT findings included lateral ventricle asymmetry/midline shift (42.8%), intracranial haemorrhage (35.7%), caudotentorial lesions (14.2%) and cranial vault fractures (14.2%), all of which were depressed. Intracranial haemorrhage was found to be significantly and negatively associated with short-term ( P = 0.005) and long-term ( P = 0.023) survival. KCTS was significantly associated with short-term survival ( P = 0.002) and long-term survival ( P = 0.004). A KCTS cut-off value of 2 yielded a 100% sensitivity and 100% specificity for short-term survival and 100% sensitivity and 80% specificity for long-term survival. A MGCS cut-off value of ⩾13 was associated with a 100% sensitivity and 100% specificity for short-term survival, and with a 100% sensitivity and 80% specificity for long-term survival. Conclusions and relevance KCTS, performed up to 72 h from injury, can be used as an additional diagnostic tool for the prediction of survival in cats with TBI.

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