Delisting of liver transplant candidates following recompensation of chronic liver diseases – patient characteristics and predictors of delisting: a prospective study

Background and Hypothesis: The impact of chronic liver diseases on patients and their family member is often understated and understudied. Chronic liver diseases can sometimes progress to a need for Liver transplant (LT). While recent studies have described quality of life (QOL) at different stages of liver disease, the impact of the patient’s QOL in LT survivors has not been examined. The importance of studying QOL in patients is due to its effect on the survivorship of LT recipients. We hypothesize that QOL in LT patients is lower than the general population. Our aim was to describe predictors of QOL in a well-described cohort of LT patients. Methods: Patients were enrolled at the Digestive and Liver Disease Liver clinic at Indiana University Hospital. All patients over the age of 18 were approached, if patients consented to the study, they were then enrolled during their liver follow up visit. The PROMIS survey was administered on an iPad and completed during the clinic visit. Survey were then scored and analyzed. Results: The T-scores for post liver transplant patients are lower in physical function, anxiety and depression, but higher in general life satisfaction compared to the general population. LT recipients have similar T-scores in Fatigue, Sleep disturbance, ability to participate in social activities, and pain interference compared to the general population. Conclusion and Potential Impact: Previous diagnosis of PBC, HCC, diagnosis of depression, household income, insurance status, Charlson Comorbid Index and number of non-transplant related medications have the highest association with quality of life. Further enrollment is needed to increase the power of the study. However, this can inform physicians the importance to taking these factors in to consideration in order to improve the QOL in LT recipients.

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Sa1936 CHALLENGES AND SUCCESS OF INTRAGASTRIC BALLOON THERAPY IN LIVER TRANSPLANT CANDIDATES: A PROSPECTIVE STUDY WITH LONG-TERM FOLLOW-UP

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2020.03.1281 ◽

2020 ◽

Vol 91 (6) ◽

pp. AB211-AB212

Author(s):

Veeravich Jaruvongvanich ◽

Julie Heimbach ◽

Monika Rizk ◽

William Sanchez ◽

John D. Port ◽

...

Keyword(s):

Prospective Study ◽

Liver Transplant ◽

Intragastric Balloon ◽

Long Term Follow Up ◽

Transplant Candidates ◽

A Prospective Study

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Analysis of antibody responses after COVID-19 vaccination in liver transplant recipients and those with chronic liver diseases

Journal of Hepatology ◽

10.1016/j.jhep.2021.08.008 ◽

2021 ◽

Author(s):

Paul J. Thuluvath ◽

Polly Robarts ◽

Mahak Chauhan

Keyword(s):

Liver Transplant ◽

Liver Diseases ◽

Chronic Liver ◽

Antibody Responses ◽

Transplant Recipients ◽

Chronic Liver Diseases ◽

Liver Transplant Recipients

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CHANGES IN CONCENTRATION OF SERUM FIBROSIS DIRECT BIOMARKERS IN CHRONIC LIVER DISEASES IN CHILDREN

PEDIATRIA Journal named after G N SPERANSKY ◽

10.24110/0031-403x-2021-100-2-112-118 ◽

2021 ◽

Vol 100 (2) ◽

pp. 112-118

Author(s):

E.A. Kulebina ◽

◽

A.N. Surkov ◽

N.M. Alyabeva ◽

I.V. Zubkova ◽

...

Keyword(s):

Liver Fibrosis ◽

Blood Serum ◽

Liver Diseases ◽

Chronic Liver ◽

Type I ◽

Chronic Liver Diseases ◽

Non Invasive ◽

Study Characteristics ◽

A Prospective Study

It is assumed that serum concentrations of type I, III, IV collagen (Col I, Col III, Col IV) and hyaluronic acid (HA) can provide informative evidence for the diagnosis of liver fibrosis (LF) using non-invasive procedures, however, there is insufficient data on the subject in paediatrics. Objectives: to study characteristics of changes in concentrations of Col I, Col III, Col IV and HA in blood serum in accordance with the stages of liver fibrosis in children. Materials and methods of research: a prospective study was carried out, which included 80 patients aged 5 to 17 years with chronic liver diseases of various etiologies, who underwent marginal resection of liver tissue under laparoscopic control, then a morphological study of the obtained biopsy was performed with determination of the stage of fibrosis on the METAVIR scale and the content of Col I, Col III, Col IV and HA in blood serum by the method of enzyme immunoassay. Results: the assessment of the content of K-I in the blood serum allows differentiating the stage F1 and F3 from F4 (p=0,025, p=0,006), Col IV – F1 from F2 (p=0,011), F3 (p=0,002) and F4 (p<0,001), HA – F1 from F3 (p=0,041), and also F4 from F1 (p<0,001), F2 (p<0,001) and F3 (p<0,001). There were no statistically significant differences in the content of Col III at different stages of LF (p=0,061). Statistically significant correlations of the histological stage of LF with changes in serological levels of Col I (ρ=–0,267, p=0,023), Col IV (ρ=0,409, p<0,001), and HA (ρ=0,575, p<0,001), and also the relationship between the concentrations of Col IV and HA (ρ=0,265, p=0,023). Conclusions: the correlations found in the histological phase of LF with changes in serological levels of Col I, Col IV and HA lead to the conclusion that fibrosis direct biomarkers are of diagnostic importance in determining the stage of LF, which is of great importance for practical medicine, especially in pediatrics.

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