scholarly journals Evaluation of reticulocyte hemoglobin content (RETIC‐HGB) for the diagnosis of iron‐limited erythropoiesis in cats

2020 ◽  
Vol 49 (4) ◽  
pp. 557-566
Author(s):  
Miriam Keiner ◽  
Jannika Fuchs ◽  
Natali Bauer ◽  
Andreas Moritz

2018 ◽  
Vol 50 (11) ◽  
pp. 1178-1182 ◽  
Author(s):  
Eloísa Urrechaga ◽  
Johannes J.M.L. Hoffmann ◽  
Antonio Bernal ◽  
Juan A. Arévalo ◽  
José L. Cabriada


2015 ◽  
Vol 30 (4) ◽  
pp. 326-334 ◽  
Author(s):  
Raeda T. Al-Ghananim ◽  
Demet Nalbant ◽  
Robert L. Schmidt ◽  
Gretchen A. Cress ◽  
M. Bridget Zimmerman ◽  
...  


Author(s):  
Azza A. Tantawy ◽  
Iman A. Ragab ◽  
Eman A. Ismail ◽  
Fatma S.E. Ebeid ◽  
Ramadan M. Al-Bshkar


Blood ◽  
1994 ◽  
Vol 83 (10) ◽  
pp. 3100-3101 ◽  
Author(s):  
C Brugnara ◽  
MR Laufer ◽  
AJ Friedman ◽  
K Bridges ◽  
O Platt


2018 ◽  
Vol 483 ◽  
pp. 20-24 ◽  
Author(s):  
A.Mireille Baart ◽  
Michiel G.J. Balvers ◽  
Maria T.E. Hopman ◽  
Thijs M.H. Eijsvogels ◽  
Jacqueline M.T. Klein Gunnewiek ◽  
...  


Author(s):  
Mauro Buttarello ◽  
Rachele Pajola ◽  
Enrica Novello ◽  
Giacomo Mezzapelle ◽  
Mario Plebani

AbstractBackground:Iron deficiency represents the most frequent cause of anemia. To diagnose iron deficiency some biochemical tests such as serum ferritin and the transferring saturation percent (TSAT%) are usually used. Recently, some hematological parameters such as mean reticulocyte hemoglobin content (CHr or Ret-He) and percentage of hypochromic RBCs (Hypo% or %Hypo-He) were proposed as alternative to biochemical tests. In this study, the analytic performance and the diagnostic efficiency of these two parameters provided by Sysmex XE5000 analyzer on iron deficiency patients with or without anemia (IDA and ID, respectively) were evaluated.Methods:One hundred and sixty-four healthy adults, 58 with IDA, 21 with iron depleted stores (ID), 23 with β-thalassemia trait, and 24 with non iron deficiency anemia were selected. The gold standard used to define iron deficiency was the coexistence of serum ferritin below 15 μg/L (12 in women) and TSAT <16%.Results:For %Hypo-He, the best cut-off value for both IDA and ID is 0.9% while for Ret-He is 30.6 pg. For both parameters the performance was better to diagnose IDA (AUC, 0.96 and 0.98) than ID (AUC, 0.93 and 0.95). The Ret-He behavior was always slightly better than that of %Hypo-He.Conclusions:The use of these two parameters is useful to detect iron deficiency conditions if the hemoglobin synthesis has already been compromised.



Anemia ◽  
2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Eloísa Urrechaga ◽  
Luís Borque ◽  
Jesús F. Escanero

Reticulocyte hemoglobin content (CHr) and percentage of hypochromic cells (%Hypo) are restricted to the Siemens analysers. The aims of the study were to investigate the correlation of Red cells size factor (RSf) and low Hemoglobin density (LHD%), reported by Beckman-Coulter analysers, with CHr and %Hypo in the assessment of iron status in the presence of inflammation. 381 samples were run on both LH 750 (Beckman-Coulter) and Advia 2120 (Siemens) analysers. Correlation between parameters were calculated and the diagnostic performance of the new parameters was assessed.Results. Correlation between RSf and CHr, . ROC curve analysis for RSf in the diagnosis of iron restricted erythropoiesis defined as CH pg: AUC 0.983; Cutoff 91.1%; Sensitivity 98.8%; Specificity 89.6% Correlation between LHD% and %Hypo, . ROC curve analysis for LHD% in the diagnosis of iron deficiency defined by %Hypo %: AUC 0.954; Cut off 6.0%; Sensitivity 96.6%; Specificity 83.2%Conclusions. RSf and LHD% could be reliable parameters for the study of iron metabolism status.





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