Corrigendum: Aorta, liver and portal vein CT contrast enhancement during the portal venous phase are positively associated with abdominal fat percentage in dogs

32-year-old man status post living donor liver transplantation for PSC Postgadolinium arterial phase image (Figure 2.19.1) demonstrates a hepatic artery stump (cutoff) at the level of the anastomosis. A subsequent axial portal venous phase image (Figure 2.19.2) at the level of the porta hepatis shows an absent main portal vein, which is confirmed on the coronal reformatted image (...

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Indicator for local recurrence of hepatocellular carcinoma after proton beam therapy: analysis of attenuation difference between the irradiated tumor and liver parenchyma on contrast enhancement CT

British Journal of Radiology ◽

10.1259/bjr.20190375 ◽

2020 ◽

Vol 93 (1105) ◽

pp. 20190375

Author(s):

Hiroaki Takahashi ◽

Yuta Sekino ◽

Kensaku Mori ◽

Toshiyuki Okumura ◽

Katsuhiro Nasu ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Local Recurrence ◽

Contrast Enhancement ◽

Proton Beam ◽

Proton Beam Therapy ◽

Liver Parenchyma ◽

Youden Index ◽

Tumor Control ◽

Portal Venous Phase ◽

Venous Phase

Objectives: We aimed to identify dynamic CT features that can be used for prediction of local recurrence of hepatocellular carcinoma (HCC) after proton beam therapy (PBT). Methods: We retrospectively retrieved CT scans of patients with PBT-treated HCC, taken between January 2004 and December 2016. 17 recurrent lesions and 34 non-recurrent lesions were retrieved. The attenuation difference between irradiated tumor and irradiated parenchyma (ADHCC-IP) was compared in the two groups by using the Mann–Whitney U test. Cut-off value of ADHCC-IP was estimated by using the Youden index. Results: The follow-up time after PBT initiation ranged from 374 to 2402 days (median, 1069 days) in recurrent lesions, and 418 to 2923 days (median, 1091.5 days) in non-recurrent lesions (p = 0.892). The time until appearance of local recurrence after PBT initiation ranged from 189 to 2270 days (median, 497 days). ADHCC-IP of recurrent lesions [mean, −21.8 Hounsfield units (HU); from −95 to −31 HU] was significantly greater than that of non-recurrent lesions (mean, −51.7 HU; from −117 to −12 HU) at 1–2 years in portal venous phase (p = 0.039). 5-year local tumor control rates were 0.93 and 0.56 in lesions with ADHCC-IP at 1–2 years in PVP < −55 and ≥ −55 HU, respectively. Conclusion: The attenuation difference between irradiated HCC and irradiated liver parenchyma in portal venous phase at 1-2 years after PBT can predict long-term local recurrence of HCC after treatment. Advances in knowledge: We identified a cut-off value for contrast enhancement of HCC after PBT that could predict future local recurrence.

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Aortic and Hepatic Contrast Enhancement During Hepatic-Arterial and Portal Venous Phase Computed Tomography Scanning

Journal of Computer Assisted Tomography ◽

10.1097/rct.0000000000000513 ◽

2017 ◽

Vol 41 (2) ◽

pp. 309-314 ◽

Cited By ~ 5

Author(s):

Takanori Masuda ◽

Takeshi Nakaura ◽

Yoshinori Funama ◽

Toru Higaki ◽

Masao Kiguchi ◽

...

Keyword(s):

Computed Tomography ◽

Contrast Enhancement ◽

Portal Venous Phase ◽

Computed Tomography Scanning ◽

Venous Phase ◽

Tomography Scanning

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Liver vessel enhancement by gd-bopta and gd-eob-dtpa: a comparison in healthy volunteers

Acta Radiologica ◽

10.1080/02841850903055603 ◽

2009 ◽

Vol 50 (7) ◽

pp. 709-715 ◽

Cited By ~ 48

Author(s):

T. B. Brismar ◽

N. Dahlström ◽

N. Edsborg ◽

A. Persson ◽

Ö. Smedby ◽

...

Keyword(s):

Portal Vein ◽

Contrast Media ◽

Signal Intensity ◽

Liver Parenchyma ◽

Middle Hepatic Vein ◽

Maximum Enhancement ◽

Liver Parenchymal ◽

Portal Venous Phase ◽

Venous Phase ◽

Parenchymal Enhancement

Background: A thorough understanding of magnetic resonance (MR) contrast media dynamics makes it possible to choose the optimal contrast media for each investigation. Differences in visualizing hepatobiliary function between Gd-BOPTA and Gd-EOB-DTPA have previously been demonstrated, but less has been published regarding differences in liver vessel visualization. Purpose: To compare the liver vessel and liver parenchymal enhancement dynamics of Gd-BOPTA (MultiHance) and Gd-EOB-DTPA (Primovist). Material and Methods: The signal intensity of the liver parenchyma, the common hepatic artery, the middle hepatic vein, and a segmental branch of the right portal vein was obtained in 10 healthy volunteers before contrast media administration, during arterial and portal venous phases, and 10, 20, 30, 40, and 130 min after intravenous contrast medium injection, but, due to scanner limitations, not during the hepatic venous phase. The doses of contrast media were 0.1 mmol/kg for Gd-BOPTA and 0.025 mmol/kg for Gd-EOB-DTPA. Results: Maximum enhancement of liver parenchyma was observed from the portal venous phase until 130 min after Gd-BOPTA administration and from 10 min to 40 min after Gd-EOB-DTPA. There was no difference in maximum enhancement of liver parenchyma between the two contrast media. When using Gd-BOPTA, the vascular contrast enhancement was still apparent 40 min after injection, but had vanished 10 min after Gd-EOB-DTPA injection. The maximum difference in signal intensity between the vessels and the liver parenchyma was significantly greater with Gd-BOPTA than with Gd-EOB-DTPA ( P<0.0001). Conclusion: At the dosage used in this study, Gd-BOPTA yields higher maximum enhancement of the hepatic artery, portal vein, and middle hepatic vein during the arterial and the portal venous phase and during the delayed phases than Gd-EOB-DTPA does, whereas there is no difference in liver parenchymal enhancement between the two contrast agents.

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Value of contrast-enhanced CT texture analysis in predicting IDH mutation status of intrahepatic cholangiocarcinoma

Scientific Reports ◽

10.1038/s41598-021-86497-4 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Yong Zhu ◽

Yingfan Mao ◽

Jun Chen ◽

Yudong Qiu ◽

Yue Guan ◽

...

Keyword(s):

Texture Analysis ◽

Ct Images ◽

Textural Features ◽

Mutation Status ◽

Portal Venous Phase ◽

Contrast Enhanced Ct ◽

Contrast Enhanced ◽

Enhanced Ct ◽

Venous Phase ◽

Ct Texture Analysis

AbstractTo explore the value of contrast-enhanced CT texture analysis in predicting isocitrate dehydrogenase (IDH) mutation status of intrahepatic cholangiocarcinomas (ICCs). Institutional review board approved this study. Contrast-enhanced CT images of 138 ICC patients (21 with IDH mutation and 117 without IDH mutation) were retrospectively reviewed. Texture analysis was performed for each lesion and compared between ICCs with and without IDH mutation. All textural features in each phase and combinations of textural features (p < 0.05) by Mann–Whitney U tests were separately used to train multiple support vector machine (SVM) classifiers. The classification generalizability and performance were evaluated using a tenfold cross-validation scheme. Among plain, arterial phase (AP), portal venous phase (VP), equilibrium phase (EP) and Sig classifiers, VP classifier showed the highest accuracy of 0.863 (sensitivity, 0.727; specificity, 0.885), with a mean area under the receiver operating characteristic curve of 0.813 in predicting IDH mutation in validation cohort. Texture features of CT images in portal venous phase could predict IDH mutation status of ICCs with SVM classifier preoperatively.

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