scholarly journals Impact of Neurapheresis System on Intrathecal Cerebrospinal Fluid Dynamics: A Computational Fluid Dynamics Study

2019 ◽  
Vol 142 (2) ◽  
Author(s):  
Mohammadreza Khani ◽  
Lucas R. Sass ◽  
Aaron R. McCabe ◽  
Laura M. Zitella Verbick ◽  
Shivanand P. Lad ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Cerebrospinal Fluid ◽  
Removal Rate ◽  
Maximum Flow ◽  
Cfd Model ◽  
Flow Loop ◽  
Steady Streaming ◽  
Lumbar Drain ◽  
The Impact

Abstract It has been hypothesized that early and rapid filtration of blood from cerebrospinal fluid (CSF) in postsubarachnoid hemorrhage patients may reduce hospital stay and related adverse events. In this study, we formulated a subject-specific computational fluid dynamics (CFD) model to parametrically investigate the impact of a novel dual-lumen catheter-based CSF filtration system, the Neurapheresis™ system (Minnetronix Neuro, Inc., St. Paul, MN), on intrathecal CSF dynamics. The operating principle of this system is to remove CSF from one location along the spine (aspiration port), externally filter the CSF routing the retentate to a waste bag, and return permeate (uncontaminated CSF) to another location along the spine (return port). The CFD model allowed parametric simulation of how the Neurapheresis system impacts intrathecal CSF velocities and steady–steady streaming under various Neurapheresis flow settings ranging from 0.5 to 2.0 ml/min and with a constant retentate removal rate of 0.2 ml/min simulation of the Neurapheresis system were compared to a lumbar drain simulation with a typical CSF removal rate setting of 0.2 ml/min. Results showed that the Neurapheresis system at a maximum flow of 2.0 ml/min increased average steady streaming CSF velocity 2× in comparison to lumbar drain (0.190 ± 0.133 versus 0.093 ± 0.107 mm/s, respectively). This affect was localized to the region within the Neurapheresis flow loop. The mean velocities introduced by the flow loop were relatively small in comparison to normal cardiac-induced CSF velocities.

scholarly journals In vitro and Numerical Simulation of Blood Removal from Cerebrospinal Fluid: Comparison of Lumbar Drain to Neurapheresis Therapy

2020 ◽  
Author(s):  
Mohammadreza Khani ◽  
Lucas Sass ◽  
M. Keith Sharp ◽  
Aaron McCabe ◽  
Laura Zitella Verbick ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Subarachnoid Space ◽  
Cfd Model ◽  
Tracer Concentration ◽  
Steady Streaming ◽  
Lumbar Drain ◽  
Spinal Subarachnoid Space ◽  
Subject Specific ◽  
The Impact

Abstract Background: Blood removal from cerebrospinal fluid (CSF) in post-subarachnoid hemorrhage patients may reduce the risk of related secondary brain injury. We formulated a computational fluid dynamics (CFD) model to investigate the impact of a dual-lumen catheter-based CSF filtration system, called Neurapheresis TM therapy, on blood removal from CSF compared to lumbar drain. Methods: A subject-specific multiphase CFD model of CSF system-wide solute transport was constructed based on MRI measurements. The Neurapheresis catheter geometry was added to the model within the spinal subarachnoid space. Neurapheresis flow aspiration and return rate was 2.0 and 1.8 (mL/min), versus 0.2 (mL/min) drainage for lumbar drain. Blood was modeled as a bulk fluid phase within CSF with a 10% initial tracer concentration and identical viscosity and density as CSF. Subject-specific oscillatory CSF flow was applied at the model inlet. The dura and spinal cord geometry were considered to be stationary. Spatial-temporal tracer concentration was quantified based on time-average steady-streaming velocities throughout the domain under Neurapheresis therapy and lumbar drain. To help verify CFD results, an optically clear in vitro CSF model was constructed with fluorescein used as a blood surrogate. Quantitative comparison of numerical and in vitro results was performed by linear regression of spatial-temporal tracer concentration over 24-hours. Results: After 24-hours, tracer concentration was reduced to 4.9% under Neurapheresis therapy compared to 6.5% under lumbar drain. Tracer clearance was most rapid between the catheter aspiration and return ports. Neurapheresis therapy was found to have a greater impact on steady-streaming compared to lumbar drain. Steady-streaming in the cranial SAS was ~50X smaller than in the spinal subarachnoid space for both cases. CFD results were strongly correlated with the in vitro spatial-temporal tracer concentration under Neurapheresis therapy (R 2 =0.89 with +2.13% and -1.93% tracer concentration confidence interval). Conclusion: A subject-specific CFD model of CSF system-wide solute transport was used to investigate the impact of Neurapheresis therapy on tracer removal from CSF compared to lumbar drain over a 24-hour period. Neurapheresis therapy was found to substantially increase tracer clearance compared to lumbar drain. The multiphase CFD results were verified by in vitro fluorescein tracer experiments.

scholarly journals Anthropomorphic Model of Intrathecal Cerebrospinal Fluid Dynamics Within the Spinal Subarachnoid Space: Spinal Cord Nerve Roots Increase Steady-Streaming

2018 ◽  
Vol 140 (8) ◽  
Author(s):  
Mohammadreza Khani ◽  
Lucas R. Sass ◽  
Tao Xing ◽  
M. Keith Sharp ◽  
Olivier Balédent ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Spinal Cord ◽  
Cerebrospinal Fluid ◽  
Cfd Model ◽  
Csf Flow ◽  
Nerve Roots ◽  
Csf Dynamics ◽  
Steady Streaming ◽  
Spinal Subarachnoid Space ◽  
The Impact

Cerebrospinal fluid (CSF) dynamics are thought to play a vital role in central nervous system (CNS) physiology. The objective of this study was to investigate the impact of spinal cord (SC) nerve roots (NR) on CSF dynamics. A subject-specific computational fluid dynamics (CFD) model of the complete spinal subarachnoid space (SSS) with and without anatomically realistic NR and nonuniform moving dura wall deformation was constructed. This CFD model allowed detailed investigation of the impact of NR on CSF velocities that is not possible in vivo using magnetic resonance imaging (MRI) or other noninvasive imaging methods. Results showed that NR altered CSF dynamics in terms of velocity field, steady-streaming, and vortical structures. Vortices occurred in the cervical spine around NR during CSF flow reversal. The magnitude of steady-streaming CSF flow increased with NR, in particular within the cervical spine. This increase was located axially upstream and downstream of NR due to the interface of adjacent vortices that formed around NR.

scholarly journals In vitro and Numerical Simulation of Blood Removal from Cerebrospinal Fluid: Comparison of Lumbar Drain to Neurapheresis Therapy

2020 ◽  
Author(s):  
Mohammadreza Khani ◽  
Lucas Sass ◽  
M. Keith Sharp ◽  
Aaron McCabe ◽  
Laura Zitella Verbick ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Subarachnoid Space ◽  
Cfd Model ◽  
Tracer Concentration ◽  
Steady Streaming ◽  
Lumbar Drain ◽  
Spinal Subarachnoid Space ◽  
Subject Specific ◽  
The Impact

Abstract Background: Blood removal from cerebrospinal fluid (CSF) in post-subarachnoid hemorrhage patients may reduce the risk of related secondary brain injury. We formulated a computational fluid dynamics (CFD) model to investigate the impact of a dual-lumen catheter-based CSF filtration system, called Neurapheresis TM therapy, on blood removal from CSF compared to lumbar drain. Methods: A subject-specific multiphase CFD model of CSF system-wide solute transport was constructed based on MRI measurements. The Neurapheresis catheter geometry was added to the model within the spinal subarachnoid space. Neurapheresis flow aspiration and return rate was 2.0 and 1.8 (mL/min), versus 0.2 (mL/min) drainage for lumbar drain. Blood was modeled as a bulk fluid phase within CSF with a 10% initial tracer concentration and identical viscosity and density as CSF. Subject-specific oscillatory CSF flow was applied at the model inlet. The dura and spinal cord geometry were considered to be stationary. Spatial-temporal tracer concentration was quantified based on time-average steady-streaming velocities throughout the domain under Neurapheresis therapy and lumbar drain. To help verify CFD results, an optically clear in vitro CSF model was constructed with fluorescein used as a blood surrogate. Quantitative comparison of numerical and in vitro results was performed by linear regression of spatial-temporal tracer concentration over 24-hours. Results: After 24-hours, tracer concentration was reduced to 4.9% under Neurapheresis therapy compared to 6.5% under lumbar drain. Tracer clearance was most rapid between the catheter aspiration and return ports. Neurapheresis therapy was found to have a greater impact on steady-streaming compared to lumbar drain. Steady-streaming in the cranial SAS was ~50X smaller than in the spinal subarachnoid space for both cases. CFD results were strongly correlated with the in vitro spatial-temporal tracer concentration under Neurapheresis therapy (R 2 =0.89 with +2.13% and -1.93% tracer concentration confidence interval). Conclusion: A subject-specific CFD model of CSF system-wide solute transport was used to investigate the impact of Neurapheresis therapy on tracer removal from CSF compared to lumbar drain over a 24-hour period. Neurapheresis therapy was found to substantially increase tracer clearance compared to lumbar drain. The multiphase CFD results were verified by in vitro fluorescein tracer experiments.

scholarly journals In vitro and Numerical Simulation of Blood Removal from Cerebrospinal Fluid: Comparison of Lumbar Drain to Neurapheresis Therapy

2020 ◽  
Author(s):  
Mohammadreza Khani ◽  
Lucas Sass ◽  
M. Keith Sharp ◽  
Aaron McCabe ◽  
Laura Zitella Verbick ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Solute Transport ◽  
Cfd Model ◽  
Tracer Concentration ◽  
Steady Streaming ◽  
Lumbar Drain ◽  
Subject Specific ◽  
Multiphase Cfd ◽  
The Impact

Abstract Background: Blood removal from cerebrospinal fluid (CSF) in post-subarachnoid hemorrhage patients may reduce the risk of related secondary brain injury. We formulated a computational fluid dynamics (CFD) model to investigate the impact of a dual-lumen catheter-based CSF filtration system, called NeurapheresisTM therapy, on blood removal from CSF compared to lumbar drain. Methods: A subject-specific multiphase CFD model of CSF system-wide solute transport was constructed based on MRI measurements. The Neurapheresis catheter geometry was added to the model within the spinal subarachnoid space (SAS). Neurapheresis flow aspiration and return rate was 2.0 and 1.8 mL/min, versus 0.2 mL/min drainage for lumbar drain. Blood was modeled as a bulk fluid phase within CSF with a 10% initial tracer concentration and identical viscosity and density as CSF. Subject-specific oscillatory CSF flow was applied at the model inlet. The dura and spinal cord geometry were considered to be stationary. Spatial-temporal tracer concentration was quantified based on time-average steady-streaming velocities throughout the domain under Neurapheresis therapy and lumbar drain. To help verify CFD results, an optically clear in vitro CSF model was constructed with fluorescein used as a blood surrogate. Quantitative comparison of numerical and in vitro results was performed by linear regression of spatial-temporal tracer concentration over 24-hours.Results: After 24-hours, tracer concentration was reduced to 4.9% under Neurapheresis therapy compared to 6.5% under lumbar drain. Tracer clearance was most rapid between the catheter aspiration and return ports. Neurapheresis therapy was found to have a greater impact on steady-streaming compared to lumbar drain. Steady-streaming in the cranial SAS was ~50X smaller than in the spinal SAS for both cases. CFD results were strongly correlated with the in vitro spatial-temporal tracer concentration under Neurapheresis therapy (R2=0.89 with +2.13% and -1.93% tracer concentration confidence interval). Conclusion: A subject-specific CFD model of CSF system-wide solute transport was used to investigate the impact of Neurapheresis therapy on tracer removal from CSF compared to lumbar drain over a 24-hour period. Neurapheresis therapy was found to substantially increase tracer clearance compared to lumbar drain. The multiphase CFD results were verified by in vitro fluorescein tracer experiments.

scholarly journals Design of Road-Side Barriers to Mitigate Air Pollution near Roads

2021 ◽  
Vol 11 (5) ◽  
pp. 2391
Author(s):  
Jose I. Huertas ◽  
Javier E. Aguirre ◽  
Omar D. Lopez Mejia ◽  
Cristian H. Lopez
Keyword(s):  
Fluid Dynamics ◽  
Air Pollution ◽  
Computational Fluid Dynamics ◽  
Sulfur Hexafluoride ◽  
Computational Domain ◽  
Cfd Model ◽  
Near Surface ◽  
The Road ◽  
Pollutant Concentrations ◽  
Highly Correlated

The effects of using solid barriers on the dispersion of air pollutants emitted from the traffic of vehicles on roads located over flat areas were quantified, aiming to identify the geometry that maximizes the mitigation effect of air pollution near the road at the lowest barrier cost. Toward that end, a near road Computational Fluid Dynamics (NR-CFD) model that simulates the dispersion phenomena occurring in the near-surface atmosphere (<250 m high) in a small computational domain (<1 km long), via Computational Fluid Dynamics (CFD) was used. Results from the NR-CFD model were highly correlated (R2 > 0.96) with the sulfur hexafluoride (SF6) concentrations measured by the US-National Oceanic and Atmospheric Administration (US-NOAA) in 2008 downwind a line source emission, for the case of a 6m near road solid straight barrier and for the case without any barrier. Then, the effects of different geometries, sizes, and locations were considered. Results showed that, under all barrier configurations, the normalized pollutant concentrations downwind the barrier are highly correlated (R2 > 0.86) to the concentrations observed without barrier. The best cost-effective configuration was observed with a quarter-ellipse barrier geometry with a height equivalent to 15% of the road width and located at the road edge, where the pollutant concentrations were 76% lower than the ones observed without any barrier.

scholarly journals The impact of nasal adhesions on airflow and mucosal cooling - a computational fluid dynamics analysis

2021 ◽  
pp. 103719
Author(s):  
Praween Senanayake ◽  
Hana Salati ◽  
Eugene Wong ◽  
Kimberley Bradshaw ◽  
Yidan Shang ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Dynamics Analysis ◽  
Computational Fluid Dynamics Analysis ◽  
The Impact

Validation of a Computationally Efficient Computational Fluid Dynamics (CFD) Model for Industrial Bubble Column Bioreactors

2014 ◽  
Vol 53 (37) ◽  
pp. 14526-14543 ◽  
Author(s):  
Dale D. McClure ◽  
Hannah Norris ◽  
John M. Kavanagh ◽  
David F. Fletcher ◽  
Geoffrey W. Barton
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Bubble Column ◽  
Cfd Model ◽  
Computationally Efficient ◽  
Computational Fluid Dynamics Cfd

scholarly journals Journal Bearing: An Integrated CFD-Analytical Approach for the Estimation of the Trajectory and Equilibrium Position

2020 ◽  
Vol 10 (23) ◽  
pp. 8573
Author(s):  
Franco Concli
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Pressure Distribution ◽  
Equilibrium Position ◽  
Analytical Approach ◽  
Journal Bearing ◽  
Cfd Model ◽  
Cavitation Model ◽  
Computational Fluid Dynamics Cfd ◽  
The Mathematical Model

For decades, journal bearings have been designed based on the half-Sommerfeld equations. The semi-analytical solution of the conservation equations for mass and momentum leads to the pressure distribution along the journal. However, this approach admits negative values for the pressure, phenomenon without experimental evidence. To overcome this, negative values of the pressure are artificially substituted with the vaporization pressure. This hypothesis leads to reasonable results, even if for a deeper understanding of the physics behind the lubrication and the supporting effects, cavitation should be considered and included in the mathematical model. In a previous paper, the author has already shown the capability of computational fluid dynamics to accurately reproduce the experimental evidences including the Kunz cavitation model in the calculations. The computational fluid dynamics (CFD) results were compared in terms of pressure distribution with experimental data coming from different configurations. The CFD model was coupled with an analytical approach in order to calculate the equilibrium position and the trajectory of the journal. Specifically, the approach was used to study a bearing that was designed to operate within tight tolerances and speeds up to almost 30,000 rpm for operation in a gearbox.

Sign in / Sign up

Export Citation Format

Share Document