A Novel Approach to Configuration Redesign: Using Multiobjective Monotonicity Analysis to Alter the Pareto-set

Abstract Configuration (or topology or embodiment) design remains a ubiquitous challenge in product design optimization and in design automation, meaning configuration design is largely driven by experience in industrial practice. In this article, we introduce a novel configuration redesign process founded on the interaction of the designer with results from rigorous multiobjective monotonicity analysis. Guided by Pareto-set dependencies, the designer seeks to reduce trade-offs among objectives or improve optimality overall, deriving redesigns that eliminate dependencies or relax active constraints. The method is demonstrated on an ingestible medical device for oral drug delivery, currently in early concept development.

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Multiobjective Monotonicity Analysis: Pareto Set Dependency and Tradeoffs Causality in Configuration Design

Journal of Mechanical Design ◽

10.1115/1.4052444 ◽

2021 ◽

pp. 1-18

Author(s):

Nökkvi S. Sigurdarson ◽

Tobias Eifler ◽

Martin Ebro ◽

Panos Y. Papalambros

Keyword(s):

Oral Drug Delivery ◽

Pareto Set ◽

Oral Drug ◽

Configuration Design ◽

Analysis Process ◽

Trade Offs ◽

Design Changes ◽

Pareto Sets ◽

Multiobjective Design ◽

Monotonicity Analysis

Abstract Multiobjective design optimization studies typically derive Pareto sets or use a scalar substitute function to capture design trade-offs, leaving it up to the designer's intuition to use this information for design refinements and decision making. Understanding the causality of trade-offs more deeply, beyond simple post-optimality parametric studies, would be particularly valuable in configuration design problems to guide configuration redesign. This paper presents the method of Multiobjective Monotonicity Analysis to identify root causes for the existence of trade-offs and the particular shape of Pareto sets. This analysis process involves reducing optimization models through constraint activity identification to a point where dependencies specific to the Pareto set and the constraints that cause them are revealed. The insights gained can then be used to target configuration design changes. We demonstrate the proposed approach in the preliminary design of a medical device for oral drug delivery

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Electrolyte-induced compositional heterogeneity: A novel approach for rate-controlled oral drug delivery

Journal of Pharmaceutical Sciences ◽

10.1021/js9901054 ◽

1999 ◽

Vol 88 (11) ◽

pp. 1140-1148 ◽

Cited By ~ 41

Author(s):

Viness Pillay ◽

Reza Fassihi

Keyword(s):

Drug Delivery ◽

Oral Drug Delivery ◽

Oral Drug ◽

Compositional Heterogeneity ◽

Novel Approach ◽

Rate Controlled

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What is the future for nanocrystal-based drug-delivery systems?

Therapeutic Delivery ◽

10.4155/tde-2020-0016 ◽

2020 ◽

Vol 11 (4) ◽

pp. 225-229 ◽

Cited By ~ 4

Author(s):

Zhongjian Chen ◽

Wei Wu ◽

Yi Lu

Keyword(s):

Drug Delivery ◽

Oral Drug Delivery ◽

Water Soluble ◽

Oral Drug ◽

Particle Properties ◽

Novel Approach ◽

The Future ◽

Water Soluble Drugs ◽

Delivery Platform

Nanocrystals are used as a drug-delivery platform for poorly water-soluble drugs and have had commercial success in oral drug delivery. We assert that the future of this technique is with cancer treatment and in the development of parenteral preparations. Advances in techniques for uniform and high-quality nanocrystals as well as deciphering the in vivo fate of nanocrystals are critical. The bottom-up technique allows for better control of particle properties, while the hybrid nanocrystal technique provides a novel approach to explore the in vivo fate of nanocrystals. Breakthroughs in these two techniques to further the development of nanocrystals are also discussed.

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"Solid Dispersion - a Novel Approach for Enhancement of Bioavailability of Poorly Soluble Drugs in Oral Drug Delivery System"

Global Journal of Pharmacy & Pharmaceutical Sciences ◽

10.19080/gjpps.2017.03.555608 ◽

2017 ◽

Vol 3 (2) ◽

Cited By ~ 1

Author(s):

Manoj Kumar Sarangi

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Solid Dispersion ◽

Oral Drug Delivery ◽

Oral Drug ◽

Poorly Soluble Drugs ◽

Novel Approach ◽

Oral Drug Delivery System ◽

Poorly Soluble

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Applications of Ion Exchange Resin in Oral Drug Delivery Systems

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v7i03.9556 ◽

2017 ◽

Vol 7 (03) ◽

Author(s):

Kathpalia Harsha ◽

Das Sukanya

Keyword(s):

Drug Delivery ◽

Ion Exchange ◽

Drug Delivery Systems ◽

Oral Drug Delivery ◽

Physical Stability ◽

Delivery Systems ◽

Oral Drug ◽

Ion Exchange Resins ◽

Exchange Resins ◽

Oral Drug Delivery Systems

Ion Exchange Resins (IER) are insoluble polymers having styrene divinylbenzene copolymer backbone that contain acidic or basic functional groups and have the ability to exchange counter ions with the surrounding aqueous solutions. From the past many years they have been widely used for purification and softening of water and in chromatographic columns, however recently their use in pharmaceutical industry has gained considerable importance. Due to the physical stability and inert nature of the resins, they can be used as a versatile vehicle to design several modified release dosage forms The ionizable drug is complexed with the resin owing to the property of ion exchange. This resin complex dissociatesin vivo to release the drug. Based on the dissociation strength of the drug from the drug resin complex, various release patterns can be achieved. Many formulation glitches can be circumvented using ion exchange resins such as bitter taste and deliquescence. These resins also aid in enhancing disintegrationand stability of formulation. This review focuses on different types of ion exchange resins, their preparation methods, chemistry, properties, incompatibilities and their application in various oral drug delivery systems as well as highlighting their use as therapeutic agents.

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