Design and Development of a Novel Infant Surgical Table for 4-DOF Patient Manipulation

2007 ◽  
Author(s):  
Kimberly Ryland ◽  
Carl A. Nelson ◽  
Thomas Hejkal
Keyword(s):  
Premature Infants ◽  
Laser Photocoagulation ◽  
Occupational Injury ◽  
Quality Care ◽  
Blood Vessel Development ◽  
Locking Mechanism ◽  
Straight Line ◽  
Vessel Development ◽  
Straight Line Mechanism ◽  
Standard Table

Retinopathy of Prematurity, caused by abnormal blood vessel development in the retina of premature infants, is a leading cause of childhood blindness. It is treated using laser photocoagulation. Current methods require the surgeon to assume awkward standing positions, which can result in injury to the surgeon if repeated often. To assist surgeons in providing quality care and prevent occupational injury, a new infant surgical table was designed. The engineered solution is an attachment to a standard surgical table, saving cost and space. This takes advantage of the adjustable height and tilt provided by the standard table, while 360° rotation designed into the attachment allows the surgeon to sit during surgery. The critical cords and tubes are routed through the attachment to avoid pulling and kinking. A four-bar locking mechanism allows easy attachment to standard medical railing. Finally, a straight line mechanism provides positive locking of the rotation, allowing precise positioning of the infant.

An Infant Surgical Table for Laser Photocoagulation: Design and Development

2008 ◽  
Vol 2 (3) ◽  
Author(s):  
Kimberly Ryland ◽  
Carl A. Nelson ◽  
Thomas Hejkal
Keyword(s):  
Laser Photocoagulation ◽  
Occupational Injury ◽  
Tracking System ◽  
Quality Care ◽  
Small Animal ◽  
Infrared Camera ◽  
Proper Function ◽  
Camera Tracking ◽  
Locking Mechanism ◽  
Straight Line Mechanism

Retinopathy of prematurity, caused by abnormal blood vessel development in the retina of premature infants, is a leading cause of childhood blindness. It is treated using laser photocoagulation. Current methods require the surgeon to assume awkward standing positions, which can result in injury to the surgeon if repeated often. To assist surgeons in providing quality care and prevent occupational injury, a new infant surgical table was designed. The engineered solution is an attachment to a standard surgical table, saving cost and space. The adjustable height and tilt provided by the standard table combined with the 360 deg rotation designed into the attachment allow the surgeon to sit during surgery. The infant table incorporates several novel features. Critical cords and tubes are routed through an aperture at the center of the attachment to avoid pulling and kinking. A four-bar locking mechanism allows easy attachment to standard medical railing. A straight-line mechanism provides positive locking of the rotation, allowing precise positioning of the infant. Load-deflection testing was carried out using an infrared camera tracking system, and expert feedback was also obtained in a clinical setting to ascertain proper function. Strength testing showed acceptably small deflections and stresses under representative loading conditions. Benchtop and clinical testing of the infant table have demonstrated that it reliably and safely meets the design objectives. The device also shows promise for use in other infant or pediatric treatment and in small-animal veterinary practice.

scholarly journals Rab35 Governs Apicobasal Polarity Through Regulation of Actin Dynamics During Sprouting Angiogenesis

2022 ◽  
Author(s):  
Caitlin R Francis ◽  
Hayle Kincross ◽  
Erich J Kushner
Keyword(s):  
Blood Vessel ◽  
Actin Polymerization ◽  
Tissue Type ◽  
Potential Contribution ◽  
Rab Gtpases ◽  
Sprouting Angiogenesis ◽  
Apicobasal Polarity ◽  
Blood Vessel Development ◽  
Vessel Development ◽  
Sprout Formation

In early blood vessel development, trafficking programs, such as those using Rab GTPases, are tasked with delivering vesicular cargo with high spatiotemporal accuracy. However, the function of many Rab trafficking proteins remain ill-defined in endothelial tissue; therefore, their relevance to blood vessel development is unknown. Rab35 has been shown to play an enigmatic role in cellular behaviors which differs greatly between tissue-type and organism. Importantly, Rab35 has never been characterized for its potential contribution in sprouting angiogenesis; thus, our goal was to map Rab35s primary function in angiogenesis. Our results demonstrate that Rab35 is critical for sprout formation; in its absence apicobasal polarity is entirely lost in vitro and in vivo. To determine mechanism, we systematically explored established Rab35 effectors and show that none are operative in endothelial cells. However, we find that Rab35 partners with DENNd1c, an evolutionarily divergent guanine exchange factor, to localize to actin. Here, Rab35 regulates actin polymerization, which is required to setup proper apicobasal polarity during sprout formation. Our findings establish that Rab35 is a potent regulator of actin architecture during blood vessel development.

scholarly journals Regenerative Medicine and Angiogenesis; Challenges and Opportunities

2020 ◽  
Vol 10 (4) ◽  
pp. 490-501
Author(s):  
Mozhgan Jahani ◽  
Davood Rezazadeh ◽  
Parisa Mohammadi ◽  
Amir Abdolmaleki ◽  
Amir Norooznezhad ◽  
...  
Keyword(s):  
Regenerative Medicine ◽  
Large Scale ◽  
Diffusion Limit ◽  
Blood Vessel Development ◽  
Engineering Technique ◽  
Challenges And Opportunities ◽  
Vessel Development ◽  
Tissue Engineering Technique

Blood vessel development is one of the most prominent steps in regenerative medicine due tothe restoration of blood flow to the ischemic tissues and providing the rapid vascularizationin clinical-sized tissue-engineered grafts. However, currently tissue engineering technique isrestricted because of the inadequate in vitro/in vivo tissue vascularization. Some challenges likeas transportation in large scale, distribution of the nutrients and poor oxygen diffusion limit theprogression of vessels in smaller than clinically relevant dimensions as well in vivo integration.In this regard, the scholars attempted to promote the vascularization process relied on the stemcells (SCs), growth factors as well as exosomes and interactions of biomaterials with all of themto enable the emergence of ideal microenvironment which is needed for treatment of unhealthyorgans or tissue regeneration and formation of new blood vessels. Thus, in the present reviewwe aim to describe these approaches, advances, obstacles and opportunities as well as theirapplication in regeneration of heart as a prominent angiogenesis-dependent organ.

Delayed Laser photocoagulation following intravitreal anti–vascular endothelial growth factor injection allows immature retinal vessels to regrow without recurrence of retinopathy of prematurity

2019 ◽  
Author(s):  
Ki Yup Nam ◽  
Ji Eun Lee ◽  
Joo Eun Lee ◽  
Hyun Wong Kim ◽  
Sang Joon Lee
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Laser Photocoagulation ◽  
Retinal Vessel ◽  
Disease Recurrence ◽  
Retinal Vessels ◽  
Vascular Endothelial ◽  
Zone Ii ◽  
Vessel Development ◽  
Endothelial Growth Factor

Abstract Purpose: The effects of delayed laser photocoagulation (LP) for ROP patients who received intravitreal anti–vascular endothelial growth factor injections (IVAs) on peripheral vascularization and disease recurrence in ROP patients. Methods: A total of 26 consecutive infant eyes of 14 patients who received IVA treatments were retrospectively investigated. The patients were divided into two groups depending on the initial treatment as follows: IVA group and prompt LP group. Recurrence of ROP, growth of the retinal vessels, and associated complications were evaluated. Results: There were 16 eyes in the IVA group and 10 eyes in the LP group. In the IVA group, delayed LP was performed in six eyes due to recurrences of ROP. In 16 eyes of the IVA group, the retinal vessels grew upto Zone III in eyes received IVA only. Among the IVA groups, Delayed LP was needed in six eyes due to ROP recurrence following IVA. Delayed LP was performed average 7~8 weeks after IVA, which could give the immature neurovascular tissues time to continue vascular development upto Zone II without further ROP recurrence. However, the prompt LP group did not show vessel development beyond the laser scar. Conclusions: Delayed LP following IVA might provide a chance for retinal vessel development in the immature retina to continue without unexpected ROP recurrences.

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