scholarly journals Rotator Cuff Tendinosis in an Animal Model: The Role of Extrinsic and Overuse Factors

2000 ◽  
Author(s):  
S. Thomopoulos ◽  
A. Esmail ◽  
J. D. Williamson ◽  
C. L. Flanagan ◽  
J. P. Iannotti ◽  
...  
Keyword(s):  
Animal Model ◽  
Soft Tissue ◽  
Rotator Cuff ◽  
Musculoskeletal System ◽  
Soft Tissue Injuries ◽  
Rotator Cuff Disease ◽  
Extrinsic Compression ◽  
In Vivo Animal Model

Abstract One of the most common soft tissue injuries of the musculoskeletal system is injury to the rotator cuff tendons of the shoulder. These injuries are commonly attributed to factors such as overuse activity and extrinsic compression. Previous studies on the rotator cuff have been based on surgical reconstructive or clinical retrospective standpoints and were not designed to test hypotheses related to the causes of rotator cuff tendinosis. Our previous study has identified the rat as an appropriate in vivo animal model in which to study rotator cuff disease based on anatomic and functional similarities [1]. The current study uses this animal model to study the roles of extrinsic compression, overuse, and overuse combined with extrinsic compression, on the development of rotator cuff tendinosis. It was hypothesized that a single injury factor would be insufficient to create persistent tendinosis and a combination of injury factors would be necessary.

Role of androgens in the growth of endometrial carcinoma: An in vivo animal model

2001 ◽  
Vol 184 (3) ◽  
pp. 303-308 ◽  
Author(s):  
Richard S. Legro ◽  
Allen R. Kunselman ◽  
Shane A. Miller ◽  
P.G. Satyaswaroop
Keyword(s):  
Animal Model ◽  
Endometrial Carcinoma ◽  
In Vivo Animal Model

scholarly journals Robotic (super) microsurgery: Feasibility of a new master‐slave platform in an in vivo animal model and future directions

2018 ◽  
Vol 118 (5) ◽  
pp. 826-831 ◽  
Author(s):  
Tom J. M. Mulken ◽  
Rutger M. Schols ◽  
Shan S. Qiu ◽  
Kaj Brouwers ◽  
Lisette T. Hoekstra ◽  
...  
Keyword(s):  
Animal Model ◽  
Future Directions ◽  
In Vivo Animal Model

Identifying the Early Effects of Mechanical Loading on the Lumbar Spine Using a Novel In Vivo Animal Model

2010 ◽  
Vol 10 (9) ◽  
pp. S75-S76
Author(s):  
Glenn P. Sanders ◽  
Sarah E. Linley ◽  
Elizabeth Brule ◽  
Scott McCallum ◽  
Eric W. Vandeventer ◽  
...  
Keyword(s):  
Animal Model ◽  
Lumbar Spine ◽  
Mechanical Loading ◽  
In Vivo Animal Model ◽  
Early Effects

ALPHA-1 ADRENOCEPTOR ANTAGONIST IMPROVES IRRITATIVE SYMPTOMS VIA SUPPRESSION OF CENTRAL AFFERENT/EFFERENT ACTIVATION: IN VIVO ANIMAL MODEL

2009 ◽  
Vol 181 (4S) ◽  
pp. 338-338
Author(s):  
Khae Hawn Kim ◽  
Sang Jin Yoon ◽  
Han Jung ◽  
Jae Hyun Bae ◽  
Jeong Gu Lee ◽  
...  
Keyword(s):  
Animal Model ◽  
Adrenoceptor Antagonist ◽  
In Vivo Animal Model

Role of Camouflage in Management of Facial Trauma Deformities

2017 ◽  
Vol 33 (06) ◽  
pp. 643-652
Author(s):  
Oliver Chin ◽  
Travis Tollefson
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Injuries ◽  
Facial Trauma ◽  
Facial Fractures ◽  
Tissue Contraction ◽  
Tissue Injuries

AbstractFacial fractures and soft tissue injuries around the eyes, nose, and mouth can be difficult to manage in the primary setting, but if untreated, the secondary correction of facial trauma is very challenging. Prevention of soft tissue contraction by restoring the skeletal framework is ideal. Staged, individualized camouflage techniques can be effective in improving outcomes.

Shoulder Tendon Repair Biomechanics Using a Polyurethane Patch in a Chronic Ovine Defect Model

2007 ◽  
Author(s):  
Kirk C. McGilvray ◽  
Amy S. Lyons ◽  
A. Simon Turner ◽  
John D. MacGillivray ◽  
Struan H. Coleman ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Tendon Repair ◽  
Soft Tissue Injuries ◽  
High Rate ◽  
Rotator Cuff Tears ◽  
Defect Model ◽  
Lower Back ◽  
System 1 ◽  
Cuff Repair

Rotator cuff disorders are one of the most common soft tissue injuries of the musculoskeletal system [1], second only to lower back pain presentations in clinical frequency [2]. Surgical repairs of chronic, massive rotator cuff tears are associated with a high rate of complications, typically by full or partial re-rupture of the repair [3,4]. The literature is replete with clinical retrospective studies or evaluation of cadaveric shoulders [5], however these studies do not address the in vivo healing characteristics of a given surgical repair. The purpose of this study was to quantitatively describe the degree of shoulder healing via biomechanical analyses using an ovine chronic infraspinatus model that was repaired with and without a polyurethane scaffold rotator cuff repair (RCR) patch.

scholarly journals Demonstration of endothelial adhesion of sickle cells in vivo: a distinct role for deformable sickle cell discocytes

Blood ◽  
1992 ◽  
Vol 79 (6) ◽  
pp. 1602-1611 ◽  
Author(s):  
ME Fabry ◽  
E Fine ◽  
V Rajanayagam ◽  
SM Factor ◽  
J Gore ◽  
...  
Keyword(s):  
Animal Model ◽  
Intact Animal ◽  
Ex Vivo ◽  
Sickle Cells ◽  
Endothelial Monolayers ◽  
Quantitative Studies ◽  
Tissue Edema ◽  
In Vivo Animal Model ◽  
Von Willebrand

Abstract Different morphologic and density classes of sickle cells (SS) may play distinct roles in the generation of vasoocclusion, explaining the complexity of this phenomena. The densest SS red blood cells (RBCs) (SS4) can induce vasoocculsion in ex vivo microcirculatory preparations as well as in an intact animal model. Previous studies of the interaction of SS deformable discocytes with endothelial monolayers or the rat ex vivo mesocecum preparation have shown adhesion that is desmopressin (dDAVP)-stimulated, von Willebrand factor (vWF)-mediated, and limited to the small venules. However, in vivo adhesion of SS RBCs to the endothelium has neither been demonstrated nor characterized; and, in particular, the relation of adhesion to vasoocclusion is unknown. Using an intact animal model that involves injecting saline- washed, density-defined SS RBCs into the femoral artery of a rat, we find that: (1) Quantitative studies of RBCs retained in the rat thigh using 99mTc-labeled RBCs and gamma camera imaging showed that dDAVP induces a threefold increase in retention of normal (AA) cells and deformable SS discocytes (SS2). (2) electron microscopy and Microfil injection show that the retention of SS2 cells is due to adhesion to the vascular endothelium with no evidence of obstruction. (3) H-1 magnetic resonance imaging showed that retention of SS4 cells induced a dose-dependent increase in tissue edema (presumable secondary to tissue hypoxia), while retention of AA or SS2 cells produced no change. We conclude that endothelial adhesion of deformable SS discocytes can be demonstrated in an in vivo animal model, that this adhesion is enhanced by dDAVP (presumably related to, but not necessarily limited to the release of vWF), and that this phenomenon per se does not lead to vasoocclusion. Nevertheless, adhesion of deformable SS discocytes may have consequences. We hypothesize that adhesion of SS discocytes could narrow the lumen of postcapillary venules and facilitate secondary trapping of SS4 cells and lead to subsequent vasoocclusion.

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