Structured Response Plan After a Ground Movement Event

2020 ◽  
Author(s):  
Yong-Yi Wang ◽  
Dunji Yu ◽  
Mike Cook
Keyword(s):  
Phase 1 ◽  
Ground Movement ◽  
Specific Information ◽  
Buried Pipelines ◽  
Phase 3 ◽  
Response Plan ◽  
A Company ◽  
Term Management ◽  
Full Pressure

Abstract The vast majority of buried pipelines are not designed to accommodate significant localized ground movement caused by landslides, earthquakes, or subsidence/settlement. When a ground movement event occurs along the ROW of a buried pipeline, it is imperative that the pipeline operator determine whether the ground movement is a threat to pipeline integrity to protect those responding to the event, those living near the affected ROW, and the environment. This paper covers the development of a response plan that provides guidance to pipeline operators responding to a ground movement event while considering the unique conditions associated with such events. The response plan covers some critical decisions after an event, including, but not limited to (1) whether the event affects the pipeline, the local ROW, or those living adjacent to the ROW, (2) control of flow, i.e., the need for shutdown or pressure reduction, and (3) work needed to return the line to full-pressure service. The overall response plan is presented in three main phases: • Phase 1: Immediate Response, • Phase 2: Follow-on Assessment and Actions, and • Phase 3: Long-term Management. The structured response plan and associated guidance are presented in a self-contained stand-alone document available from PRCI. Parts of the document or the entire document can be adopted by operators, depending on the extent of existing procedures an operator may have. Alternatively, company-specific information and procedures can be added to the document to form a company-specific SOP.

STRUCTURAL CHANGES IN PRIMARY LENTICELS OF NORWAY SPRUCE OVER THE SEASONS

IAWA Journal ◽  
2003 ◽  
Vol 24 (2) ◽  
pp. 105-116 ◽  
Author(s):  
Sabine Rosner ◽  
Birgit Kartusch
Keyword(s):  
Norway Spruce ◽  
Structural Changes ◽  
Phase 1 ◽  
Late Summer ◽  
Early Summer ◽  
Climatic Conditions ◽  
Wall Thickening ◽  
Intercellular Spaces ◽  
Phase 3

Seasonal production of lenticel tissues was compared between Norway spruce trees (Picea abies (L.) Karst.) from a mountain site (1200 m), where they are autochthonous, and seven allochthonous lowland sites (250–600 m).The periodic changes of lenticel structure were grouped into four stages, based on the degree of their opening: phase 1 - winter dormancy; phase 2 - beginning of meristem activity in spring; phase 3 - production of non-suberised filling tissue in early summer, which causes the disruption of the closing layer formed in the previous growing season; and phase 4 - differentiation of a new closing layer in late summer. Structural changes in lenticels of P. abies may be interpreted as a long-term reaction to climatic conditions, balancing transpiration and respiration. During the most active period of wood production, lenticels were found in their most permeable phase, phase 3. The production of a new closing layer takes place when summer temperatures reach maximum values, and when demand for effective regulation of transpiration is high. During phase 4 transpiration is successfully controlled because differentiating cells of the new closing layer are already suberised, although not in their final rounded shape, and therefore have small intercellular spaces. High annual variability in stratification of lenticel tissues, such as the proportion between closing layer and filling tissue, wall thickening and size of intercellular spaces, also indicates possible long-term regulation mechanisms for transpiration.

scholarly journals Defining the Supportive Care Needs and Psychological Morbidity of Patients With Functioning Versus Nonfunctioning Neuroendocrine Tumors: Protocol for a Phase 1 Trial of a Nurse-Led Online and Phone-Based Intervention

10.2196/14361 ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. e14361
Author(s):  
Lisa Guccione ◽  
Karla Gough ◽  
Allison Drosdowsky ◽  
Krista Fisher ◽  
Timothy Price ◽  
...  
Keyword(s):  
Supportive Care ◽  
Qualitative Data ◽  
Phase 1 ◽  
Patient Experiences ◽  
Specific Information ◽  
Pilot Test ◽  
Phase 2 ◽  
Care Needs ◽  
Phase 3 ◽  
Disease Specific

Background Online information resources and support have been demonstrated to positively influence the well-being of people diagnosed with cancer. This has been explored in past literature for more common cancers; however, for rare cancers, such as neuroendocrine tumors (NETs), there are little to no support or resources available. Despite relatively good prognoses, the quality of life (QoL) of patients with NETs is significantly lower compared with samples of mixed cancer patients and the general population. Patients with NETs also typically report unclear and difficult pathways of disease management and treatment, given the heterogeneity of the diagnosis. There is a vital need to improve the availability of disease-specific information for this patient group and provide supportive care that is tailored to the unique needs of the NET patient population. Objective This study described the protocol of a study aimed to better understand the outcomes and experiences of patients diagnosed with NETs and to develop and pilot test a nurse-led online and phone-based intervention that will provide tailored supportive care targeted to NET subgroups (functioning vs nonfunctioning). Methods This is a multisite cohort with 3 phases, incorporating both quantitative and qualitative data collection. Phase 1 is a mixed methods prospective cohort study of NET patients identifying differences in patient experiences and priority of needs between NET subgroups. Phase 2 utilizes results from phase 1 to develop an online and nurse-led phone-based intervention. Phase 3 is to pilot test and evaluate the intervention’s acceptability, appropriateness, and feasibility. Results Currently, the project is progressing through phase 1 and has completed recruitment. A total of 138 participants have been recruited to the study. To date, patient-reported outcome data from 123 participants at baseline and 87 participants at 6-month follow-up have been collected. Of these, qualitative data from semistructured interviews from 35 participants have also been obtained. Phase 2 and phase 3 of the project are yet to be completed. Conclusions Limited research for patients with NETs suggests that QoL and patient experiences are significantly impaired compared with the general population. Furthermore, past research has failed to delineate how the clinical variability between those with functioning and nonfunctioning NETs impacts patient supportive care needs. This study will improve on the availability of disease-specific information as well as informing the design of a nurse-led online and phone-based supportive care intervention tailored for the unique needs of the NET patient population. International Registered Report Identifier (IRRID) DERR1-10.2196/14361

scholarly journals Active Learning Strategies and Competency-Based Design in Research Education: a Longitudinal Review

2019 ◽  
Vol 19 (4) ◽  
Author(s):  
Noela A. Haughton
Keyword(s):  
Learning Strategies ◽  
Phase 1 ◽  
Methods Course ◽  
Phase 3 ◽  
Research Education ◽  
Graduate Research ◽  
Active Learning Strategies ◽  
Competency Based ◽  
Multiple Levels

This paper describes the long-term re-development of an introductory graduate research methods course. The initial design is presented, followed by the two re-design phases. Phase 2 introduced additional inquiry-based strategies such as concept mapping and multiple levels of peer collaboration. Phase 3 incorporated competency-based techniques as well as additional technical, social, and instructional support. Assessment results, student feedback, moderate to strong relationships between scores on key assessments, and design principles support the assertion that the Phase 3 course is an improvement over the Phase 1 version. Limitations and further research are presented.

Safety of TG-C: 12 years of follow-up safety data from phase 1, phase 2, ongoing phase 3, and long term safety trials

2021 ◽  
Vol 29 ◽  
pp. S253-S254
Author(s):  
D. Hunter ◽  
A. Mobasheri ◽  
S. Mareya ◽  
M. Wang ◽  
H. Choi ◽  
...  
Keyword(s):  
Phase 1 ◽  
Safety Data ◽  
Phase 2 ◽  
Phase 3 ◽  
Ongoing Phase

Long-Term Memory of Pigeons for Stimulus-Outcome Associations Involving Multiple Stimuli, each Seen in a Single Brief Trial

1992 ◽  
Vol 45 (2b) ◽  
pp. 81-98 ◽  
Author(s):  
Euan M. Macphail ◽  
Steve Reilly ◽  
Mark Good
Keyword(s):  
Recognition Memory ◽  
Phase 1 ◽  
Cycle Phase ◽  
Long Term Memory ◽  
Phase 2 ◽  
Phase 3 ◽  
Term Memory ◽  
The One ◽  
High Level

Experiment 1 explored performance of pigeons in two versions of a shortterm recognition memory procedure. In one version responding to entirely novel slides was rewarded, and responding to familiar slides (slides seen once, for 10 sec) was not rewarded; in the other version, responding to familiar slides was rewarded. Performance was initially below chance in both versions of the procedure. This result indicated that in this procedure associations were formed between the slides and the outcome (reward or non-reward) that followed their presentation. The result also suggested that the true capacity of pigeon recognition memory cannot be assessed using these procedures, as performance is inevitably disrupted by the bird's associative memory. The tendency of pigeons to form one-trial associations was exploited in Experiment 2. Phase 1 consisted of 16 two-session cycles: in Session 1 of each cycle, birds were shown 20 novel slides and were rewarded for responding to 10 of those slides; in Session 2, the same slides were shown again, with the same reinforcement contingencies. The birds showed significant overnight retention of the one-trial associations formed in Session 1 of each cycle. Phase 2 showed significant retention over periods of more than 20 days of associations involving 320 slides seen twice only. Phase 3 re-exposed for nine daily sessions one of the sets of 20 slides used in Phases 1 and 2; a high level of discrimination emerged rapidly and 4 (of 8) birds showed, by the end of training, no overlap in response rates to positive and negative slides. Comparative implications of the results are discussed.

Understanding the Results of CATIE in the Context of the Field

CNS Spectrums ◽  
2006 ◽  
Vol 11 (S7) ◽  
pp. 40-47 ◽  
Author(s):  
Ira D. Glick
Keyword(s):  
Side Effects ◽  
Treatment Adherence ◽  
Atypical Antipsychotics ◽  
Phase 1 ◽  
Metabolic Effects ◽  
Valid Assessment ◽  
The Individual ◽  
Meta Analyses ◽  
Term Management

AbstractThe Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study was undertaken to provide a valid assessment of the differences between conventional and atypical antipsychotics and among the atypicals themselves in patients with schizophrenia. The CATIE investigators reported that while none of the study medications were ideal, olanzapine was the most effective in terms of treatment discontinuation, and there were no significant differences in effectiveness between the conventional antipsychotic perphenazine and the atypicals quetiapine, risperidone, and ziprasidone. Each drug differed slightly in rates of side effects, with more patients discontinuing perphenazine due to extrapyramidal side effects and more patients discontinuing olanzapine due to weight gain and metabolic effects. In order for data from phase 1 of the CATIE study to be interpreted within the appropriate context, physicians must understand how aspects of study design and statistical methods affect interpretation, and how this trial weighs against other data in the literature. This article enumerates the factors that complicate our understanding of the CATIE results and compares these findings with those from previously published meta-analyses. It is clear that therapeutic and side effects of antipsychotics vary from person to person. The goal of schizophrenia management is to maintain pharmacotherapeutic efficacy and tolerability over the long-term in order to maximize treatment adherence and benefits. What should emerge from CATIE is a renewed commitment to tailor schizophrenia treatment to the individual patient for long-term management.

THE EFFECTS OF CIGARETTE SMOKING ON RABBIT TIBIAL VASCULAR ENDOTHELIUM

2001 ◽  
Vol 05 (04) ◽  
pp. 235-242 ◽  
Author(s):  
YUAN-KUN TU ◽  
STEVE WEN-NENG UENG
Keyword(s):  
Cigarette Smoking ◽  
Vascular Endothelium ◽  
Phase 1 ◽  
Phase 2 ◽  
Short Term ◽  
Phase 3 ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Cigarette smoking is hazardous for various tissues in human. The cigarette smoke inhalation has been proved to delay bone healing. However, no previous study demonstrates the smoking effect on bony microcirculation. In this study, we investigated the effect of cigarette smoking on tibial vascular endothelium and blood flow by using the bone chamber model. Eighteen adult New Zealand rabbits were divided into 3 groups. Group 1: Control, Group 2: 1 week smoking, and Group 3: 6 weeks smoking. All these rabbits were then anesthetized, and their nutrient arteries of tibia were identified and cannulated. We put the tibia into bone chamber after cannulation, perfused with Krebs-Ringer solution (phase 1), and then compared the effect of vasospasm by norepinephrine dose-response curve (NEDRC). Acetylcholine (phase 2) and L-NMMA (phase 3) were also perfused and the NEDRC recorded. Acetylcholine can stimulate the release of nitric oxide and lower the NEDRC. L-NMMA inhibits NO synthesis in vascular endothelium, and hence results in vasoconstriction under various stimuli. Data collection and statistic processing were performed by ANOVA analysis. The NEDRC data in Group 1 (control) was set to be 100%. In phase 1 study, our results showed that 1 week cigarette smoking significantly increased NEDRC in Group 2 (142.5%, p<0.01). However, 6 weeks smoking strikingly boosted the response of NEDRC in Group 3 (226.5%, p<0.01). In phase 2 study, Group 2 tibia showed the NEDRC under acetylcholine perfusion to be without any difference in comparison with Group 1 (p>0.05). Nevertheless, Group 3 tibia showed significant vasospasm even under acetylcholine perfusion. In phase 3 study, L-NMMA perfused data revealed that; Group 3 tibia had the highest NEDRC, i.e. the most severe vasospasm. Based on our study, both short-term and long-term cigarette smoking are hazardous to the bony vascular endothelium. The nitric oxide production significantly attenuated in Group 2 and 3 tibia. However, the adverse effect of smoking seems reversible in short-term (Group 2). Long-term smoking (Group 3) causes irreversible damage to vascular endothelium and muscarinic receptor.

scholarly journals Trattamento LVRC: nuovo imaging interventistico per il trattamento dell’enfisema polmonare

2019 ◽  
Author(s):  
Erika Vallefuoco ◽  
Andrea Caldeo
Keyword(s):  
Side Effects ◽  
Pulmonary Emphysema ◽  
Phase 1 ◽  
Phase 2 ◽  
Lung Volume Reduction ◽  
Phase 3 ◽  
Thoracic Imaging ◽  
Total Absence ◽  
Clinical Benefits

Background Background Treatment of pulmonary emphysema with Lung Volume Reduction Coil (LVRC) technique and related thoracic imaging preoperative, interventional, under radioscopic guidance, and postoperative. Materials and methods For the intervention, Nitinol coils are used, implanted through a catheter under radioscopic guidance using an Intensifier. The treatment is performed with induction of anesthesia, during one or two sessions. Results Coils are implanted on patients in different lobars regions, depending on the case. The patient's status is monitored in 3 phases: Phase 1 Preoperative; Phase 2 Intervention; Phase 3 Post-operative up to the following 5 years. This technique, given the effectiveness and an almost total absence of side effects, turns out to be a valid alternative to others methods for the treatment of severe pulmonary emphysema. Conclusions Through the analysis of the monitoring results, it is possible to infer that the patients subjected to LVRC (Coil) have high clinical benefits, but still not accompanied by significant long-term functional improvements.

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