Quantitative Hemodynamic Comparison of Velocity Values From Computational Fluid Dynamics and Phase-Contrast MRI in an In-Vitro Aneurysm Model

2012 ◽  
Author(s):  
Stephanie M. George ◽  
Amos Cao ◽  
Don P. Giddens ◽  
John N. Oshinski ◽  
Frank C. Tong
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Phase Contrast ◽  
Poor Correlation ◽  
Phase Contrast Mri ◽  
General Acceptance ◽  
Contrast Magnetic Resonance ◽  
Measured Flow ◽  
Aneurysm Model

Intracranial aneurysms affect thousands of people every year, therefore the ability to monitor their growth or predict their rupture would be invaluable for planning treatment. One proposed method to address this issue of predicting rupture is to use computational fluid dynamics (CFD) based on phase contrast magnetic resonance (PC-MR). CFD and PCMR have been used to understand some of the fundamental conditions of cerebrovascular flow. While there has been general acceptance of the validity of CFD, some research suggests that there can be poor correlation between CFD flow calculations and directly measured flow (1). Previous research has qualitatively compared CFD to PC-MR and demonstrated similar pathlines (2). To the authors’ knowledge a systematic quantitative comparison has not been preformed. Therefore the purpose of this work is to quantitatively compare velocity data from phase-contrast MRI measurements and from a CFD model derived from MRI geometry and flow boundary conditions in an in-vitro aneurysm model.

Estimating the Hemodynamic Impact of Interventional Treatments of Aneurysms

Neurosurgery ◽  
2006 ◽  
Vol 59 (2) ◽  
pp. E429-E430 ◽  
Author(s):  
Gabriel Acevedo-Bolton ◽  
Liang-Der Jou ◽  
Bradley P. Dispensa ◽  
Michael T. Lawton ◽  
Randall T. Higashida ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Magnetic Resonance ◽  
Phase Contrast ◽  
Resonance Imaging ◽  
Contrast Magnetic Resonance Imaging ◽  
Phase Contrast Magnetic Resonance ◽  
Contrast Magnetic Resonance

Abstract OBJECTIVE: The goal of this study was to use phase-contrast magnetic resonance imaging and computational fluid dynamics to estimate the hemodynamic outcome that might result from different interventional options for treating a patient with a giant fusiform aneurysm. METHODS: We followed a group of patients with giant intracranial aneurysms who have no clear surgical options. One patient demonstrated dramatic aneurysm growth and was selected for further analysis. The aneurysm geometry and input and output flow conditions were measured with contrast-enhanced magnetic resonance angiography and phase-contrast magnetic resonance imaging. The data was imported into a computational fluid dynamics program and the velocity fields and wall shear stress distributions were calculated for the presenting physiological condition and for cases in which the opposing vertebral arteries were either occluded or opened. These models were validated with in vitro flow experiments using a geometrically exact silicone flow phantom. RESULTS: Simulation indicated that altering the flow ratio in the two vertebrals would deflect the main blood jet into the aneurysm belly, and that this would likely reduce the extent of the region of low wall shear stress in the growth zone. CONCLUSIONS: Computational fluid dynamics flow simulations in a complex patient-specific aneurysm geometry were validated by in vivo and in vitro phase-contrast magnetic resonance imaging, and were shown to be useful in modeling the likely hemodynamic impact of interventional treatment of the aneurysm.

Comparative Computational Fluid Dynamics and Experimental Phase-Contrast MRI: Evaluations of In-Stent Restenosis

2004 ◽  
Author(s):  
Andrea D. Holton ◽  
Brigitta C. Brott ◽  
Edward G. Walsh ◽  
Ramakrishna Venugopalan ◽  
Alan M. Shih ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Phase Contrast ◽  
Imaging Modality ◽  
Metal Stents ◽  
Phase Contrast Mri ◽  
Peripheral Vasculature ◽  
Susceptibility Artifacts ◽  
Stent Restenosis ◽  
In Stent Restenosis

While angiography and other translesional catheter-based assessments of stented peripheral vasculature are currently used in clinical applications, a quantitative non-invasive imaging modality would improve the treatment of intermediate levels of in-stent restenosis (ISR). The use of magnetic resonance imaging (MRI), in metal stents has been limited due to magnetic susceptibility artifacts and radiofrequency shielding effects. However, MRI compatible materials such as nickel-titanium alloys used in stents have shown superior lumen visibility. In this study, we used phase contrast MRI in a flow phantom of three different geometries of stenosis: a) 90% axisymmetric, b) 75% axisymmetric and c) 50% asymmetric. The velocity distribution was obtained at 3 different locations inside the stent. This was compared with an equivalent computational fluid dynamics (CFD) model of the same stenotic geometries.

Computational Analyses of an In-Vitro Aneurysm Model Based on Three-Dimensional Angiography With Comparison to Phase Contrast Magnetic Resonance Imaging and Dye Injection Studies

2010 ◽  
Author(s):  
Stephanie M. George ◽  
Pierre Watson ◽  
John N. Oshinski ◽  
Charles W. Kerber ◽  
Daniel Karolyi ◽  
...  
Keyword(s):  
High Speed ◽  
Phase Contrast ◽  
Cfd Simulation ◽  
Fluid Dynamic ◽  
Three Dimensional ◽  
Cerebral Aneurysms ◽  
Computational Fluid Dynamic Simulation ◽  
Poor Correlation ◽  
Aneurysm Model

Computational fluid dynamic simulation (CFD) is a valuable tool that has been used to understand some of the fundamental conditions of cerebrovascular flow. Current methods include anatomic modeling of cerebral aneurysms derived from vascular imaging such as MRA, CTA, and three-dimensional angiography. The input blood flow waveforms can be represented from either mathematical models or physiologic sampling of flow with phase contrast MR techniques or particle image velocimetry (1). While there has been general acceptance of the validity of computational fluid dynamics, some research suggests that there can be poor correlation between CFD flow calculations and directly measured flow (2). Therefore, the purpose of this study is to qualitatively compare flow patterns in a cerebral aneurysm model using data derived from three sources: (i) direct phase contrast MRA measurement in the model; (ii) CFD simulation using computer models created from three dimensional angiography, and (iii) previously published high speed injection dye studies.

scholarly journals Velocity Measurement in Carotid Artery: Quantitative Comparison of Time-Resolved 3D Phase-Contrast MRI and Image-based Computational Fluid Dynamics

2015 ◽  
Vol 12 (4) ◽  
Author(s):  
Ali Sarrami-Foroushani ◽  
Mohsen Nasr Esfahany ◽  
Abbas Nasiraei Moghaddam ◽  
Hamidreza Saligheh Rad ◽  
Kavous Firouznia ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Carotid Artery ◽  
Velocity Measurement ◽  
Phase Contrast ◽  
Quantitative Comparison ◽  
Phase Contrast Mri ◽  
Time Resolved

scholarly journals 3D Cine Phase-Contrast MRI at 3T in Intracranial Aneurysms Compared with Patient-Specific Computational Fluid Dynamics

2013 ◽  
Vol 34 (9) ◽  
pp. 1785-1791 ◽  
Author(s):  
P. van Ooij ◽  
J.J. Schneiders ◽  
H.A. Marquering ◽  
C.B. Majoie ◽  
E. van Bavel ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Intracranial Aneurysms ◽  
Phase Contrast ◽  
Patient Specific ◽  
Phase Contrast Mri ◽  
Cine Phase Contrast
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