Retrograde urethrosonography with SonoVue in strictures of the male urethra: a pilot study

Aim: To evaluate the effectiveness of SonoVue urethrosonography in diagnosing the adult male anterior urethral strictures pathology in comparison with retrograde urethrography.Material and method: We standardised the method and performed a comparative study evaluating the diagnosis of urethral strictures using retrograde urethrography and retrograde ultrasonographic exploration with SonoVue on 6 male patients.Results: In all patients, the existence of urethral stricture, localization and its extension were confirmed. Contrast-enhanced ultrasonographic exploration brought additional categories of information: the degree of spongiofibrosis, the elasticity of the urethral walls and the presence of urethral lithiasis. There were no periprocedural incidents.Conclusion: This pilot study demonstrates the feasibility and innocuity of urethral ultrasound with SonoVue. Real-time ultrasound exploration highlights aspects that are not seen in radiological examination, so the method can be complementary or alternative to this procedure.

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Letter to the editor re: Retrograde urethrography, sonouretrography and magnetic resonance urethrography in evaluation of male urethral strictures: should the novel methods become the new standard in radiological diagnosis of urethral stricture disease? Mikolaj et al., IJUN (October 2021)

International Urology and Nephrology ◽

10.1007/s11255-021-03090-4 ◽

2022 ◽

Author(s):

Daniel P. McNicholas ◽

Ahmad M. Omar ◽

Rauf N. Khadr ◽

Michael S. Floyd

Keyword(s):

Magnetic Resonance ◽

Urethral Stricture ◽

Radiological Diagnosis ◽

The Novel ◽

Urethral Stricture Disease ◽

Urethral Strictures ◽

Letter To The Editor ◽

Retrograde Urethrography ◽

Novel Methods

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Preliminary Internal Urethrotomy in 1036 Cases to Prevent Urethral Stricture Following Transurethral Resection; Caliber of Normal Adult Male Urethra

The Journal of Urology ◽

10.1016/s0022-5347(17)64656-1 ◽

1963 ◽

Vol 89 (6) ◽

pp. 829-835 ◽

Cited By ~ 42

Author(s):

John L. Emmett ◽

Stephen N. Rous ◽

Laurence F. Greene ◽

James H. DeWeerd ◽

David C. Utz

Keyword(s):

Urethral Stricture ◽

Adult Male ◽

Transurethral Resection ◽

Normal Adult ◽

Male Urethra ◽

Internal Urethrotomy

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Comparing retrograde urethrography readings with intraoperative findings in urethral stricture

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20192523 ◽

2019 ◽

Vol 7 (6) ◽

pp. 2333

Author(s):

Tanvi Subhash Kelkar ◽

Anil Joshi

Keyword(s):

Urinary Tract ◽

Urethral Stricture ◽

Lower Urinary Tract ◽

Operating Characteristics ◽

Medical College ◽

Urethral Strictures ◽

Retrograde Urethrography ◽

Common Location ◽

Operative Findings ◽

Lower Urinary

Background: Urethral strictures are relatively common in men with most patients acquiring the disease due to injury or infection. The present study was conducted to assess the accuracy of retrograde urethrography (RGU) in diagnosing urethral strictures in patients presenting with lower urinary tract symptoms.Methods: All male patients presenting with lower urinary tract symptoms and referred for retrograde urethrogram to the Department of Radiodiagnosis, Bharati Vidyapeeth Medical College and Hospital (Deemed to be University), Sangli from November 2018 till January 2019 were included. The parameters of RGU were compared with intra-operative findings as gold standard to calculate the operating characteristics of RGU.Results: The present study included 42 patients, mean age 54.9±11.2 years. Grade I urethral stricture was observed in 42.8% and 26% had grade II stricture. Bulbar stricture was the most common location. The common presenting complaints were increased frequency (50%) and dribbling micturition (40.4%). Approximately one tenth of all patients had a history of trauma. RGU was 100% sensitive and 66.7% specific in detecting strictures of less than 2 cm. Overall accuracy of RGU in detecting urethral strictures of less than 2 cm was 83.3%.Conclusions: RGU is a reliable means for establishing the diagnosis of a suspected urethral stricture and also provides accurate staging information with regard to stricture number, length, location, and coexistent urethral pathology.

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Tubularized Urethral Reconstruction Using Everted Saphenous Vein Graft in A Beagle Model

10.21203/rs.3.rs-74278/v1 ◽

2020 ◽

Author(s):

Dan Li ◽

Zhou Shen ◽

Yujie Xu

Keyword(s):

Urethral Stricture ◽

Saphenous Vein ◽

Vein Graft ◽

Saphenous Vein Graft ◽

Control Group ◽

Urethral Reconstruction ◽

Urethral Strictures ◽

Retrograde Urethrography ◽

Urethral Defect ◽

Experimental Group

Abstract Background: The repair of anterior urethral stricture and hypospadias require urethral reconstruction. We conduct the study to investigate the efficacy of anterior urethral reconstruction using everted saphenous vein graft in tubular fashion. Methods: Twelve male beagles were randomly divided into three groups: experimental group( n=5), control group( n=5) and normal group( n=2). A 3 cm defect in anterior urethra was created. Autologous saphenous vein graft was harvested. In experimental group, urethral defect was replaced by everted saphenous vein graft in tubular fashion. In control group, urethral reconstruction was performed using uneverted saphenous vein graft. At 6 months postoperatively, beagles in all groups received retrograde urethrography to evaluate urethral patency and were killed for histological examination. Results: Retrograde urethrography showed the urethral caliber of beagles in experimental group were similar to those of normal. Ether urethral stricture or fistula were detected in all animals in control group. In experimental group, the everted saphenous vein graft completely integrated into the urethra. The reconstructed urethra had a wide lumen and was completely covered by urothelium. The subepithelial collagen and muscle fibers were well formed and highly organized. Everted saphenous vein graft had a high ability of neovascularization. In control group, the reconstructed segment had a fibrotic urethral lumen in which urothelium was not intact. And there were few newly formed capillaries. Conclusions: Everted saphenous vein graft can be used as tubular substitute material for anterior urethral strictures and hypospadias.

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Contrast-enhanced ultrasound of the abdominal aorta – current status and future perspectives

VASA ◽

10.1024/0301-1526/a000749 ◽

2019 ◽

Vol 48 (2) ◽

pp. 115-125 ◽

Cited By ~ 4

Author(s):

Xin Li ◽

Daniel Staub ◽

Vasileios Rafailidis ◽

Mohammed Al-Natour ◽

Sanjeeva Kalva ◽

...

Keyword(s):

Real Time ◽

Vascular Diseases ◽

Aneurysm Rupture ◽

Vasa Vasorum ◽

Current Status ◽

Contrast Enhanced Ultrasound ◽

Aortic Diseases ◽

Cross Sectional ◽

Vascular Abnormalities ◽

Contrast Enhanced

Abstract. Ultrasound has been established as an important diagnostic tool in assessing vascular abnormalities. Standard B-mode and Doppler techniques have inherent limitations with regards to detection of slow flow and small vasculature. Contrast-enhanced ultrasound (CEUS) is a complementary tool and is useful in assessing both the macro- and microvascular anatomy of the aorta. CEUS can also provide valuable physiological information in real-time scanning sessions due to the physical and safety profiles of the administered microbubbles. From a macrovascular perspective, CEUS has been used to characterize aortic aneurysm rupture, dissection and endoleaks post-EVAR repair. With regard to microvasculature CEUS enables imaging of adventitial vasa vasorum thereby assessing aortic inflammation processes, such as monitoring treatment response in chronic periaortitis. CEUS may have additional clinical utility since adventitial vasa vasorum has important implications in the pathogenesis of aortic diseases. In recent years, there have been an increasing number of studies comparing CEUS to cross-sectional imaging for aortic applications. For endoleak surveillance CEUS has been shown to be equal or in certain cases superior in comparison to CT angiography. The recent advancement of CEUS software along with the ongoing development of drug-eluting contrast microbubbles has allowed improved targeted detection and real-time ultrasound guided therapy for aortic vasa vasorum inflammation and neovascularization in animal models. Therefore, CEUS is uniquely suited to comprehensively assess and potentially treat aortic vascular diseases in the future.

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