Correlation of functional and resting state connectivity of cerebral oxy-, deoxy-, and total hemoglobin concentration changes measured by near-infrared spectrophotometry

Abstract A portable near infrared spectroscopy (NIRS) system was used to evaluate alterations in cerebral total hemoglobin concentration (HbT) in individuals with orthostatic hypotension (OH) and orthostatic intolerance (OI) symptoms. We enrolled 238 healthy participants (mean age, 47.9 years) and assessed the presence of OH (orthostatic blood pressure (BP) drop of systolic BP ≥ 20 mmHg or diastolic BP ≥ 10 mmHg within 3 minutes of supine-to-stand) and OI symptoms using the OH questionnaire. The participants were categorized into three groups based on the presence of OH and OI symptoms: the classic OH (OH-BP) group, symptom alone (OH-Sx) group, and control group. Random case-control matching sets (age, sex, hypertension, and diabetes mellitus) were constructed consisting of 16 OH-BP and 69 OH-Sx-control sets. We measured the time-derivative of HbT change in the prefrontal cortex during the squat-to-stand maneuver. There were no differences in demographics, baseline BP, and heart rate among the matched sets. Among the NIRS parameters, the peak-time of maximum slope variation was significantly longer in the OH-Sx and OH-BP groups than in the matched control groups during transition to the standing position after squatting. Our results suggested that OH and OI symptoms are associated with dynamic alteration in cerebral HbT.

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fNIRS Monitoring of Infant Prefrontal Cortex During Crawling and an Executive Functioning Task

Frontiers in Behavioral Neuroscience ◽

10.3389/fnbeh.2021.675366 ◽

2021 ◽

Vol 15 ◽

Author(s):

Hannah Weibley ◽

Mina Di Filippo ◽

Xinran Liu ◽

Lillian Lazenby ◽

Jackson Goscha ◽

...

Keyword(s):

Prefrontal Cortex ◽

Near Infrared ◽

Brain Activity ◽

Hemoglobin Concentration ◽

Blood Oxygenation ◽

Functional Near Infrared Spectroscopy ◽

Attention Task ◽

Total Hemoglobin ◽

Measured Activity ◽

Total Hemoglobin Concentration

Functional near-infrared spectroscopy (fNIRS)is a brain-imaging technology used to reveal brain activity by measuring blood oxygenation. Using fNIRS we measured activity in the left prefrontal lobe of 8–14 month-old infants as they crawled or were pushed in a stroller and as they were given a passive attention task or an active executive function (EF) task. For each task, we measured peak total hemoglobin concentration and peak Oxy relative to baseline. Results revealed differences in peak Oxy levels for crawling vs. strolling and between the EF and passive cognitive tasks, with total hemoglobin greater for the EF task than the passive attention task. These results support the theoretical view that both active locomotion and EF engage the prefrontal cortex (PFC) during early development.

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Effect of Source-Detector Distance on the Measurement of Hemoglobin Using Near-Infrared Spectroscopy in Breast Cancer

Technology in Cancer Research & Treatment ◽

10.1177/1533033819830411 ◽

2019 ◽

Vol 18 ◽

pp. 153303381983041

Author(s):

Maho Hayashi ◽

Nobuko Yoshizawa ◽

Yukio Ueda ◽

Tetsuya Mimura ◽

Etsuko Ohmae ◽

...

Keyword(s):

Chest Wall ◽

Near Infrared ◽

Hemoglobin Concentration ◽

Breast Tumors ◽

Contralateral Breast ◽

Target Area ◽

Total Hemoglobin ◽

Detector Distance ◽

The Difference ◽

Total Hemoglobin Concentration

We measured total hemoglobin concentrations in breast tumors by near-infrared time-resolved spectroscopy. Muscles interfere with measurement when the probe is close to the chest wall. Since the target area of measurement depends on the distance between the light source and probe detector, we inferred that this issue could be solved by reducing the source-detector distance. The purpose of this study was to examine the effects of the source-detector distance on the measurement of total hemoglobin concentration in the breast. We examined 26 patients with breast tumors. Total hemoglobin concentration was measured in tumors and the contralateral normal breasts at source-detector distances of 20 and 30 mm. The difference in total hemoglobin concentration between each tumor and the contralateral breast was calculated. The normal breast total hemoglobin concentration was significantly smaller for the source-detector distance of 20 mm than for the source-detector distance of 30 mm. Differences in source-detector distance did not significantly affect tumor total hemoglobin. The difference in total hemoglobin concentration between the tumor and the contralateral breast obtained at the source-detector distance of 20 mm was significantly higher than that obtained at the source-detector distance of 30 mm. From these results, we considered that measurement with a source-detector distance of 20 mm is less affected by the chest wall than with a source-detector distance of 30 mm and that the difference in total hemoglobin concentration between the tumor and the contralateral breast at a source-detector distance of 20 mm can better reflect the net total hemoglobin concentrations of the breast tumors. In conclusion, using a probe with a source-detector distance of 20 mm can more accurately evaluate the total hemoglobin concentration in breast tumors.

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Regional differences of cerebral hemoglobin concentration in preterm infants measured by near infrared spectrophotometry

Technology and Health Care ◽

10.3233/thc-1999-7105 ◽

1999 ◽

Vol 7 (1) ◽

pp. 63-73 ◽

Cited By ~ 3

Author(s):

Matthias Keel ◽

Martin Wolf ◽

Oskar Baenziger ◽

Vera Dietz ◽

Kurt von Siebenthal ◽

...

Keyword(s):

Preterm Infants ◽

Regional Differences ◽

Near Infrared ◽

Hemoglobin Concentration ◽

Infrared Spectrophotometry

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Oxygen affinity of blood in altitude Sherpas

Journal of Applied Physiology ◽

10.1152/jappl.1979.47.2.337 ◽

1979 ◽

Vol 47 (2) ◽

pp. 337-341 ◽

Cited By ~ 44

Author(s):

M. Samaja ◽

A. Veicsteinas ◽

P. Cerretelli

Keyword(s):

Sea Level ◽

Concentration Ratio ◽

Oxygen Affinity ◽

Hemoglobin Concentration ◽

Cell Counts ◽

Blood Cell Counts ◽

Total Hemoglobin ◽

The Mean ◽

Total Hemoglobin Concentration ◽

2,3 Dpg

Oxygen equilibrium curves on blood within 6 h from sampling have been estimated from polarographic measurements of oxyhemoglobin concentration, in 13 male 14- to 50-yr old Sherpas residing at 3,850 m above sea level (Kumjung, Nepal). In samples with red blood cell counts = 4.7 +/- 0.8 (SD) x 10(6)/mm3, total hemoglobin concentration [Hb] = 17.0 +/- 1.9 g/dl, and hematocrit = 53.3 +/- 5.0, the mean oxygen half-saturation of hemoglobin (P50) (pH = 7.4 and PCO2 = 40 Torr) was 27.3 +/- 1.8 Torr. The P50 of altitude Sherpas was not significantly different from that of acclimatized lowlanders (28.2 +/- 1.3; n = 7), sea-level Caucasian residents (26.5 +/- 1.0; n = 17), and Sherpas at sea level (27.1; n = 3). The 2,3-diphosphoglyceric acid-to-hemoglobin concentration ratio ([2,3-DPG]/[Hb]) in altitude Sherpas was 1.22 +/- 0.03, the same as that of acclimatized Caucasians (1.22 +/- 0.10). The Bohr effect measured for the blood of one altitude Sherpas by the ratio deltalog P50/deltapH was -0.32 and -0.45 at PCO2 levels of 40 and 20 Torr, respectively. These values are not significantly different from those found in Caucasians at sea level where deltalog P50/deltalpH was -0.35 and -0.42, respectively. It is concluded that the P50 in native highlanders is not significantly different from that observed in sea-level dwellers. [2,3-DPG]/[Hb] at altitude, both in natives and in newcomers, is 20% higher than in sea-level residents.

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Resting state connectivity patterns with near-infrared spectroscopy data of the whole head

Biomedical Optics Express ◽

10.1364/boe.7.002524 ◽

2016 ◽

Vol 7 (7) ◽

pp. 2524 ◽

Cited By ~ 13

Author(s):

Sergio L. Novi ◽

Renato B. M. L. Rodrigues ◽

Rickson C. Mesquita

Keyword(s):

Infrared Spectroscopy ◽

Near Infrared Spectroscopy ◽

Resting State ◽

Near Infrared ◽

Spectroscopy Data ◽

Connectivity Patterns ◽

Resting State Connectivity

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Optoacoustic monitoring of total hemoglobin concentration: In vitro and in vivo studies

Biomedical Topical Meeting ◽

10.1364/bio.2004.fh4 ◽

2004 ◽

Author(s):

I. Y. Petrova ◽

D. S. Prough ◽

Y. Y. Petrov ◽

H.- P. F. Brecht ◽

C. Svensen ◽

...

Keyword(s):

Hemoglobin Concentration ◽

In Vivo Studies ◽

Total Hemoglobin ◽

Total Hemoglobin Concentration

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Results of routine determination of clinically significant hemoglobin derivatives by multicomponent analysis.

Clinical Chemistry ◽

10.1093/clinchem/32.6.972 ◽

1986 ◽

Vol 32 (6) ◽

pp. 972-978 ◽

Cited By ~ 24

Author(s):

A Zwart ◽

E J van Kampen ◽

W G Zijlstra

Keyword(s):

Pulmonary Disease ◽

Fetal Hemoglobin ◽

Hemoglobin Concentration ◽

Major Surgery ◽

Chemical Laboratory ◽

Total Hemoglobin ◽

Clinically Significant ◽

Blood Specimens ◽

Total Hemoglobin Concentration

Abstract Our recently developed multiwavelength method for multi-component analysis of hemoglobin (Hb) derivatives (Clin Chem 1984;30:373-379) was adapted for routine use in the clinical chemical laboratory. The method was applied in 4066 determinations on blood specimens from patients awaiting major surgery (n = 3863) or visiting the outpatient department for pulmonary disease (n = 203). Mean total hemoglobin concentration was 141 (SD 14) g/L. The proportion of HbCO was slightly to moderately increased (1.5-10.0%) in 36.5% of all patients; in a few cases it was as high as 15%. Mean methemoglobin was 0.4% (SD 0.2%) in the surgical patients, but 1.5% (SD 0.8%) in the patients with pulmonary disease. In some patients of the latter group the proportion of methemoglobin amounted to 5%. Sulfhemoglobin was found less than 0.4% in all specimens. Interference by paraproteins and by increased concentrations of bilirubin and lipids in plasma was easily detected by means of the performance checks provided by the spectrophotometer (an HP 8451 UV/Vis). The method is equally suitable for measuring blood samples containing fetal hemoglobin.

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