Real-time guidance of minimally-invasive peripheral vascular access procedures using a point of care LED-based photoacoustic and ultrasound imaging system

The purpose of our study was to investigate serial ultrasound imaging in rats as a means to quantify the diameters of splanchnic veins in real time and the effect of drugs on venous capacitance. A 21 MHz probe ( Vevo 2100 imaging system,Visual Sonics Inc.) was used to collect images containing the portal vein (PV) and the superior mesenteric vein (SMV) in anesthetized male Sprague-Dawley rats maintained at 37°C. Stable landmarks were established and we were able to repeatedly locate specific cross-sections of PV and SMV. When controlled for respiratory and cardiac cycles during measurements, respective diameters of these vessels remained within 0.75±0.15% and 0.2±0.10% of baseline (PV: 2.02±0.15 mm; SMV: 1.67±0.05 mm) when located and measured every 5 minutes over 45 minutes (n=3 rats). PV and SMV remained within 1.0±0.6% and 0.38±0.9% from baseline, respectively, when measured on separate days over 10 weeks in a preliminary study using 2 rats. The consistency of raw vessel measurements allowed these vessels to serve as their own control during subchronic pharmacologic interventions. In a second study, the vasodilator sodium nitroprusside (2 mg/kg, i.v. bolus) was administered to anesthetized rats (n=3) following collection of baseline vessel measurements. PV and SMV diameters increased 37.23±2.4% and 29.77±8.8% from baseline by 30 minutes post drug administration while mean arterial pressure decreased 10.32±1.7 mmHg. Conversely, the administration of the venoconstrictor sarafotoxin (S6C) (5 ng/kg, i.v. bolus) to other anesthetized rats (n=3) decreased PV and SMV diameters 22.10±2.4% and 9.44±1.6% from baseline within 5 minutes, associated with an increase in mean arterial pressure of 12.85±3.2 mmHg. Together these results support serial ultrasound imaging as a reliable technique to accurately measure acute and subchronic changes in the diameter of splanchnic veins concurrent with blood pressure changes in intact rats. The ability to follow rat abdominal vein diameters in real time will assist in determining the role of the venous circulation in blood pressure regulation.

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A real-time realization of an automatic dynamic range adjustment method on a smart mobile device for point-of-care ultrasound imaging

2014 IEEE International Ultrasonics Symposium ◽

10.1109/ultsym.2014.0303 ◽

2014 ◽

Author(s):

Jee Hoo Kim ◽

YeonHwa Lee ◽

Jinbum Kang ◽

Yangmo Yoo

Keyword(s):

Real Time ◽

Ultrasound Imaging ◽

Mobile Device ◽

Dynamic Range ◽

Point Of Care ◽

Point Of Care Ultrasound ◽

Adjustment Method ◽

Smart Mobile

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Enabling low-cost point-of-care ultrasound imaging system using single element transducer and delta configuration actuator

Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling ◽

10.1117/12.2513169 ◽

2019 ◽

Cited By ~ 1

Author(s):

Keshuai Xu ◽

Younsu Kim ◽

Emad M. Boctor ◽

Haichong K. Zhang

Keyword(s):

Ultrasound Imaging ◽

Imaging System ◽

Point Of Care ◽

Low Cost ◽

Single Element ◽

Point Of Care Ultrasound

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Towards clinical photoacoustic and ultrasound imaging: Probe improvement and real-time graphical user interface

Experimental Biology and Medicine ◽

10.1177/1535370219889968 ◽

2020 ◽

Vol 245 (4) ◽

pp. 321-329 ◽

Cited By ~ 6

Author(s):

Jeesu Kim ◽

Eun-Yeong Park ◽

Byullee Park ◽

Wonseok Choi ◽

Ki J Lee ◽

...

Keyword(s):

User Interface ◽

Real Time ◽

Ultrasound Imaging ◽

Graphical User Interface ◽

Imaging System ◽

Photoacoustic Imaging ◽

Clinical Applications ◽

Imaging Systems ◽

Imaging Probe ◽

Conventional Ultrasound

Photoacoustic imaging is a non-invasive and non-ionizing biomedical technique that has been investigated widely for various clinical applications. By taking the advantages of conventional ultrasound imaging, hand-held operation with a linear array transducer should be favorable for successful clinical translation of photoacoustic imaging. In this paper, we present new key updates contributed to the previously developed real-time clinical photoacoustic and ultrasound imaging system for improving the clinical usability of the system. We developed a seamless image optimization platform, designed a real-time parameter control software with a user-friendly graphical user interface, performed Monte Carlo simulation of the optical fluence in the imaging plane, and optimized the geometry of the imaging probe. The updated system allows optimizing of all imaging parameters while continuously acquiring the photoacoustic and ultrasound images in real-time. The updated system has great potential to be used in a variety of clinical applications such as assessing the malignancy of thyroid cancer, breast cancer, and melanoma. Impact statement Photoacoustic imaging is a promising biomedical imaging modality that can visualize both structural and functional information of biological tissue. Because of its easiness to be integrated with conventional ultrasound imaging systems, numerous studies have been conducted to develop and apply clinical photoacoustic imaging systems. However, most of the systems were not suitable for general-purpose clinical applications due to one of the following reasons: target specific design, immobility, inaccessible operation sequence, and lack of hand-held operation. This study demonstrates a real-time clinical photoacoustic and ultrasound imaging system, which can overcome the limitations of the previous systems for successful clinical translation.

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