Low frequency power in cerebral blood flow through cardiac arrest and recovery in a swine model

2021 ◽  
Author(s):  
Brian White ◽  
Tiffany Ko ◽  
Ryan W. Morgan ◽  
Jharna Jahnavi ◽  
Emilie . Benson ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cardiac Arrest ◽  
Cerebral Blood Flow ◽  
Low Frequency ◽  
Swine Model ◽  
Flow Through ◽  
Low Frequency Power ◽  
Frequency Power

scholarly journals Cerebral blood flow and cerebrovascular autoregulation in a swine model of pediatric cardiac arrest and hypothermia*

2011 ◽  
Vol 39 (10) ◽  
pp. 2337-2345 ◽  
Author(s):  
Jennifer K. Lee ◽  
Ken M. Brady ◽  
Jennifer O. Mytar ◽  
Kathleen K. Kibler ◽  
Erin L. Carter ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cardiac Arrest ◽  
Cerebral Blood Flow ◽  
Swine Model ◽  
Cerebrovascular Autoregulation

Abstract 102: Inhaled Nitric Oxide Mitigates Pulmonary Hypertension and Improves Cerebral Hemodynamics During Prolonged Cardiopulmonary Pesuscitation in a Swine Model of Pediatric Cardiac Arrest

Circulation ◽  
2018 ◽  
Vol 138 (Suppl_2) ◽  
Author(s):  
Constantine D Mavroudis ◽  
Ryan W Morgan ◽  
Tiffany S Ko ◽  
Marco M Hefti ◽  
William P Landis ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Pulmonary Hypertension ◽  
Cardiac Arrest ◽  
Cerebral Blood Flow ◽  
Pulmonary Artery ◽  
Pulmonary Artery Pressure ◽  
Systemic Hemodynamics ◽  
Swine Model ◽  
Pulmonary Vasodilation

Introduction: Pulmonary hypertension may play a role in preventing ROSC during prolonged CPR. Targeted pulmonary vasodilation with inhaled nitric oxide (iNO) during CPR may improve pulmonary blood flow and improve outcomes. The purpose of this study was to study the effects of iNO in a randomized, blinded, placebo controlled, pediatric swine model of asphyxial cardiac arrest. Hypothesis: Animals treated with iNO will have lower pulmonary artery pressure, improved systemic hemodynamics, and increased cerebral blood flow during prolonged CPR compared to control. Methods: Four-week-old piglets (n=10) that underwent seven minutes of asphyxia, induction of VF, and 10 minutes of CPR were randomized to either iNO (20 ppm) or placebo in a blinded fashion starting one min into CPR and needed more than 1 defibrillation attempt. Defibrillation was attempted after 10 minutes of CPR. Animals that did not achieve ROSC by 20 minutes were euthanized. Invasive pulmonary and systemic hemodynamics, and both invasive and noninvasive cerebral hemodynamics were continuously measured. Data described as mean ± SD and compared using a generalized estimating equation regression model. Results: All 5 iNO-treated animals and 2/5 placebo-treated animals achieved ROSC. Those treated with iNO had lower mean pulmonary artery pressures (29.5 ± 9.1 vs. 48.3 ± 5.6 mmHg, p=0.04); higher mean aortic pressures (51.9 ± 6.4 vs. 35.5 ± 4.4 mmHg, p=0.01); higher cerebral blood flow (invasive: 230.4 ± 57.4 vs. 28.7 ± 42.1 % baseline, p<0.001; noninvasive: 58.4 ± 10.9 vs. 32.4 ± 8.1 % baseline, p=0.02); and higher cerebral tissue oxygenation (invasive: 33.1 ± 13.0 vs. 1.2 ± 9.8 mmHg, p=0.01; noninvasive: 38.0 ± 4.2 vs. 26.2 ± 3.1%, p=0.005) compared with placebo. Conclusions: Treatment with iNO during prolonged CPR results in lower pulmonary artery pressure, improved systemic hemodynamics, and increased cerebral blood flow and oxygenation. Pulmonary vasodilation may have an important role during prolonged CPR for asphyxial cardiac arrests.

scholarly journals Hypothermia-Induced Neuroprotection is Associated with Reduced Mitochondrial Membrane Permeability in a Swine Model of Cardiac Arrest

2014 ◽  
Vol 34 (3) ◽  
pp. 552-552
Author(s):  
Ping Gong ◽  
Rong Hua ◽  
Yu Zhang ◽  
Hong Zhao ◽  
Ziren Tang ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cardiac Arrest ◽  
Cerebral Blood Flow ◽  
Membrane Permeability ◽  
Mitochondrial Membrane ◽  
Liaoning Province ◽  
Swine Model ◽  
Mitochondrial Membrane Permeability

Correction to: Journal of Cerebral Blood Flow & Metabolism (2013) 33, 928–934; doi: 10.1038/jcbfm.2013.33 ; published online 13 March 2013 A fund grant number was incorrectly omitted from the Acknowledgements. The following sentence should be read with the Funding Statement: ‘This work was supported by the Liaoning Province Nature Science Foundation (Grant No. 2013023020).’

scholarly journals Toward asleep DBS: cortico-basal ganglia spectral and coherence activity during interleaved propofol/ketamine sedation mimics NREM/REM sleep activity

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Jing Guang ◽  
Halen Baker ◽  
Orilia Ben-Yishay Nizri ◽  
Shimon Firman ◽  
Uri Werner-Reiss ◽  
...  
Keyword(s):  
Basal Ganglia ◽  
Rem Sleep ◽  
Standard Procedure ◽  
Low Frequency ◽  
Nrem Sleep ◽  
Sleep Cycle ◽  
Advanced Parkinson’S Disease ◽  
Low Frequency Power ◽  
The Brain ◽  
Frequency Power

AbstractDeep brain stimulation (DBS) is currently a standard procedure for advanced Parkinson’s disease. Many centers employ awake physiological navigation and stimulation assessment to optimize DBS localization and outcome. To enable DBS under sedation, asleep DBS, we characterized the cortico-basal ganglia neuronal network of two nonhuman primates under propofol, ketamine, and interleaved propofol-ketamine (IPK) sedation. Further, we compared these sedation states in the healthy and Parkinsonian condition to those of healthy sleep. Ketamine increases high-frequency power and synchronization while propofol increases low-frequency power and synchronization in polysomnography and neuronal activity recordings. Thus, ketamine does not mask the low-frequency oscillations used for physiological navigation toward the basal ganglia DBS targets. The brain spectral state under ketamine and propofol mimicked rapid eye movement (REM) and Non-REM (NREM) sleep activity, respectively, and the IPK protocol resembles the NREM-REM sleep cycle. These promising results are a meaningful step toward asleep DBS with nondistorted physiological navigation.

Cortical low‐frequency power correlates with behavioral impairment in animal model of focal limbic seizures

Epilepsia ◽  
2021 ◽  
Author(s):  
Abhijeet Gummadavelli ◽  
Reese Martin ◽  
Derek Goshay ◽  
Lim‐Anna Sieu ◽  
Jingwen Xu ◽  
...  
Keyword(s):  
Animal Model ◽  
Low Frequency ◽  
Behavioral Impairment ◽  
Limbic Seizures ◽  
Low Frequency Power ◽  
Frequency Power

Low-frequency heating of doublets

1981 ◽  
Vol 25 (1) ◽  
pp. 133-143 ◽  
Author(s):  
T. H. Jensen ◽  
F. W. McClain ◽  
H. Grad
Keyword(s):  
Physical Model ◽  
Linear Theory ◽  
Low Frequency ◽  
Plasma Temperature ◽  
Auxiliary Heating ◽  
Power Sources ◽  
Axisymmetric Mode ◽  
Low Frequency Power ◽  
Frequency Power ◽  
Frequency Heating

Heating of a doublet plasma by driving an axisymmetric mode at low frequency may be an attractive means for auxiliary heating. The attractiveness of the method stems from (1) the low technology required for low-frequency power sources, (2) the fact that the field-shaping coils required for doublets may also be used as the antennae for transmitting the power, (3) the possibility of transmitting the power through a resistive vacuum wall, (4) the insensitivity to the plasma temperature and density and (5) the relative simplicity of the physical model. The utility of the concept depends on the existence of a special axisymmetric eigenmode in the resistive M.HD approximation which is used. This mode has nodes through the elliptic axes of the doublet equilibrium and an antinode at the hyperbolic axis. It is remarkable that the dissipation per cycle of this mode remains large at low plasma resistivity. This paper describes a linear theory for such heating.

Difficulties in assessing brain death in a case of benzodiazepine poisoning with persistent cerebral blood flow

2004 ◽  
Vol 23 (10) ◽  
pp. 503-505 ◽  
Author(s):  
Frédéric Marrache ◽  
Bruno Megarbane ◽  
Stéphane Pirnay ◽  
Abdel Rhaoui ◽  
Marie Thuong
Keyword(s):  
Blood Flow ◽  
Cardiac Arrest ◽  
Cerebral Blood Flow ◽  
Brain Death ◽  
Intracranial Hypertension ◽  
Multiorgan Failure ◽  
Deep Coma ◽  
Ventricular Drainage ◽  
Eeg Activity ◽  
Anoxic Injury

Assessing brain death may sometimes be difficult, with isoelectric EEG following psychotrope overdoses or normal cerebral blood flow (CBF) persisting despite brain death in the case of ventricular drainage or craniotomy. A 42-year-old man, resuscitated after cardiac arrest following a suicidal ingestion of ethanol, bromazepam and zopiclone, was admitted in deep coma. On day 4, his brainstem reflexes and EEG activity disappeared. On day 5, his serum bromazepam concentration was 817 ng/ml (therapeutic: 80-150). The patient was unresponsive to 1 mg of flumazenil. MRI showed diffuse cerebral swelling. CBF assessed by angiography and Doppler remained normal and EEG isoelectric until he died on day 8 with multiorgan failure. There was a discrepancy between the clinically and EEG-assessed brain death, and CBF persistence. We hypothesized that brain death, resulting from diffuse anoxic injury, may lead, in the absence of major intracranial hypertension, to angiographic misdiagnoses. Therefore, EEG remains useful to assess diagnosis in such unusual cases.

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