scholarly journals Rate of long-term bleaching in FK 51 optical glass darkened by Co60 ionizing radiation at dose rates of 10 krad/hr and 7rad/hr

1997 ◽  
Author(s):  
G. R. Wirtenson ◽  
Richard H. White
Keyword(s):  
Ionizing Radiation ◽  
Optical Glass ◽  
Dose Rates

scholarly journals RADIOLOGICAL ASSESSMENT OF IONIZING RADIATION IMPACT ON THE TERRESTRIAL NON-HUMAN BIOTA IN LITHUANIA

2015 ◽  
Vol 23 (4) ◽  
pp. 295-301 ◽  
Author(s):  
Marina KONSTANTINOVA ◽  
Nina PROKOPČIUK ◽  
Arūnas GUDELIS ◽  
Donatas BUTKUS
Keyword(s):  
Ionizing Radiation ◽  
Nuclear Power ◽  
Activity Concentration ◽  
Assessment Tool ◽  
Natural Radionuclides ◽  
Soil Layer ◽  
Software Application ◽  
Dose Rates ◽  
Top Soil

The quantitative assessment of radionuclides transfer to non-human biota using their activity concentration ratios is required for models of predictive doses of ionizing radiation. Based on long-term data regarding activity concentration of radionuclides in the top soil layer of the entire territory of Lithuania, and with the help of ERICA Assessment Tool – a software application that calculates dose rates to selected biota, we estimated the radiological impact on the terrestrial non-human biota with special emphasis on the protected areas located in the vicinity of Ignalina Nuclear Power Plant (INPP). Estimated total dose rates of artificial radionuclides – after-Chernobyl 137Cs and 90Sr as well as discharged by INPP – and natural radionuclides, such as 238U and 232Th, were found to be less than ERICA screening value of 10 μGy h–1.

Ovarian Dysfunction in Fetally Irradiated Beagles

1977 ◽  
Vol 35 ◽  
pp. 658-659
Author(s):  
T. M. Seed ◽  
M. H. Sanderson ◽  
D. L. Gutzeit ◽  
T. E. Fritz ◽  
D. V. Tolle ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Low Dose ◽  
Long Term Effects ◽  
Ovarian Dysfunction ◽  
Dose Rates ◽  
Highly Sensitive ◽  
Microscopic Evaluation ◽  
Ovarian Pathology ◽  
Normal Offspring

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

Amifostine-Loaded Dissolving Armored Microneedles for Long-Term Prevention of Ionizing Radiation-Induced Injury

2020 ◽  
Author(s):  
Xiang Yu ◽  
Minshu Li ◽  
Lin Zhu ◽  
Jingfei li ◽  
Guoli Zhang ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Radiation Induced

scholarly journals Effect of ionizing radiation on human skeletal muscle precursor cells

2013 ◽  
Vol 47 (4) ◽  
pp. 376-381 ◽  
Author(s):  
Mihaela Jurdana ◽  
Maja Cemazar ◽  
Katarina Pegan ◽  
Tomaz Mars
Keyword(s):  
Skeletal Muscle ◽  
Stress Response ◽  
Ionizing Radiation ◽  
Human Skeletal Muscle ◽  
Long Term Effects ◽  
Post Irradiation ◽  
Acute Response ◽  
Proliferation Capacity ◽  
Myoblast Proliferation

Abstract Background. Long term effects of different doses of ionizing radiation on human skeletal muscle myoblast proliferation, cytokine signalling and stress response capacity were studied in primary cell cultures. Materials and methods. Human skeletal muscle myoblasts obtained from muscle biopsies were cultured and irradiated with a Darpac 2000 X-ray unit at doses of 4, 6 and 8 Gy. Acute effects of radiation were studied by interleukin - 6 (IL-6) release and stress response detected by the heat shock protein (HSP) level, while long term effects were followed by proliferation capacity and cell death. Results. Compared with non-irradiated control and cells treated with inhibitor of cell proliferation Ara C, myoblast proliferation decreased 72 h post-irradiation, this effect was more pronounced with increasing doses. Post-irradiation myoblast survival determined by measurement of released LDH enzyme activity revealed increased activity after exposure to irradiation. The acute response of myoblasts to lower doses of irradiation (4 and 6 Gy) was decreased secretion of constitutive IL-6. Higher doses of irradiation triggered a stress response in myoblasts, determined by increased levels of stress markers (HSPs 27 and 70). Conclusions. Our results show that myoblasts are sensitive to irradiation in terms of their proliferation capacity and capacity to secret IL-6. Since myoblast proliferation and differentiation are a key stage in muscle regeneration, this effect of irradiation needs to be taken in account, particularly in certain clinical conditions.

Long-term cytogenetic follow-up studies on humans after internal and external exposures to ionizing radiation

2021 ◽  
Author(s):  
Adayabalam Sambasivan Balajee ◽  
Gordon K Livingston ◽  
Maria B Escalona ◽  
Terri L Ryan ◽  
Ronald E Goans ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Follow Up Studies ◽  
External Exposures

scholarly journals Investigation of dose-rate effects and cell-cycle distribution under protracted exposure to ionizing radiation for various dose-rates

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Yusuke Matsuya ◽  
Stephen J. McMahon ◽  
Kaori Tsutsumi ◽  
Kohei Sasaki ◽  
Go Okuyama ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Ionizing Radiation ◽  
Dose Rate ◽  
Cell Cycle Distribution ◽  
Dose Rates ◽  
Dose Rate Effects ◽  
Rate Effects

scholarly journals Differential expression of NPM, GSTA3, and GNMT in mouse liver following long-term in vivo irradiation by means of uranium tailings

2018 ◽  
Vol 38 (5) ◽  
Author(s):  
Lan Yi ◽  
Hongxiang Mu ◽  
Nan Hu ◽  
Jing Sun ◽  
Jie Yin ◽  
...  
Keyword(s):  
Gamma Radiation ◽  
Radiation Exposure ◽  
Central Vein ◽  
Glutathione S Transferase ◽  
Γ Radiation ◽  
Dose Rates ◽  
Living Organisms ◽  
Uranium Tailings

Uranium tailings (UT) are formed as a byproduct of uranium mining and are of potential risk to living organisms. In the present study, we sought to identify potential biomarkers associated with chronic exposure to low dose rate γ radiation originating from UT. We exposed C57BL/6J mice to 30, 100, or 250 μGy/h of gamma radiation originating from UT samples. Nine animals were included in each treatment group. We observed that the liver central vein was significantly enlarged in mice exposed to dose rates of 100 and 250 μGy/h, when compared with nonirradiated controls. Using proteomic techniques, we identified 18 proteins that were differentially expressed (by a factor of at least 2.5-fold) in exposed animals, when compared with controls. We chose glycine N-methyltransferase (GNMT), glutathione S-transferase A3 (GSTA3), and nucleophosmin (NPM) for further investigations. Our data showed that GNMT (at 100 and 250 μGy/h) and NPM (at 250 μGy/h) were up-regulated, and GSTA3 was down-regulated in all of the irradiated groups, indicating that their expression is modulated by chronic gamma radiation exposure. GNMT, GSTA3, and NPM may therefore prove useful as biomarkers of gamma radiation exposure associated with UT. The mechanisms underlying those changes need to be further studied.

Cell and Tissue Damage after Skin Exposure to Ionizing Radiation: Short- and Long-Term Effects after a Single and Fractional Doses

2014 ◽  
Vol 200 (3-4) ◽  
pp. 240-252 ◽  
Author(s):  
Kahori Kinoshita ◽  
Hisako Ishimine ◽  
Kenshiro Shiraishi ◽  
Harunosuke Kato ◽  
Kentaro Doi ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Tissue Damage ◽  
Long Term Effects ◽  
Skin Exposure ◽  
Short And Long Term

scholarly journals Effects of Ionizing Radiation and Long-Term Storage on Hydrated vs. Dried Cell Samples of Extremophilic Microorganisms

2022 ◽  
Vol 10 (1) ◽  
pp. 190
Author(s):  
Ida Romano ◽  
Carlo Camerlingo ◽  
Lisa Vaccari ◽  
Giovanni Birarda ◽  
Annarita Poli ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Galactic Cosmic Rays ◽  
Cellular Growth ◽  
Space Environment ◽  
Water Medium ◽  
Space Condition ◽  
Long Term Storage ◽  
Extremophilic Microorganisms ◽  
Term Storage

A main factor hampering life in space is represented by high atomic number nuclei and energy (HZE) ions that constitute about 1% of the galactic cosmic rays. In the frame of the “STARLIFE” project, we accessed the Heavy Ion Medical Accelerator (HIMAC) facility of the National Institute of Radiological Sciences (NIRS) in Chiba, Japan. By means of this facility, the extremophilic species Haloterrigena hispanica and Parageobacillus thermantarcticus were irradiated with high LET ions (i.e., Fe, Ar, and He ions) at doses corresponding to long permanence in the space environment. The survivability of HZE-treated cells depended upon either the storage time and the hydration state during irradiation; indeed, dry samples were shown to be more resistant than hydrated ones. With particular regard to spores of the species P. thermantarcticus, they were the most resistant to irradiation in a water medium: an analysis of the changes in their biochemical fingerprinting during irradiation showed that, below the survivability threshold, the spores undergo to a germination-like process, while for higher doses, inactivation takes place as a consequence of the concomitant release of the core’s content and a loss of integrity of the main cellular components. Overall, the results reported here suggest that the selected extremophilic microorganisms could serve as biological model for space simulation and/or real space condition exposure, since they showed good resistance to ionizing radiation exposure and were able to resume cellular growth after long-term storage.

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