The grid brings a new era to the Internet, by introducing new mechanisms, resources, and concepts which allow it to advance from a passive information medium into an active tool for creating, exploring, and sharing knowledge. In the meanwhile, the realisation of this trend is further spurred by the emergence of next generation grids (NGG) and the far more efficient, cost-effective, and broadly applicable infrastructure they introduce to cover a broader spectrum of business needs. Towards this direction and taking into account that mobility has become a central aspect in business, education, and entertainment, mobile grid has been recently developed as a full inheritor of grid covering the mobility aspects of applications, such as m-learning. In this context, this book chapter focuses on providing a business-technical presentation of mobile grid, as an enabling technology for next generation m-learning applications. We present a general mobile grid architecture able to serve the strict requirements such an m-learning application poses, and analyse the main trends and challenges in the mentioned sector.