Auditory habituation as a diagnostic measure of domoic acid toxicosis in wild sea lions.

2011 ◽  
Vol 129 (4) ◽  
pp. 2432-2432
Author(s):  
Peter Cook ◽  
Colleen Reichmuth ◽  
Frances Gulland
Keyword(s):  
Domoic Acid ◽  
Diagnostic Measure ◽  
Sea Lions ◽  
Domoic Acid Toxicosis

scholarly journals Serum profiling by MALDI-TOF mass spectrometry as a diagnostic tool for domoic acid toxicosis in California sea lions

2012 ◽  
Vol 10 (1) ◽  
pp. 18 ◽  
Author(s):  
Benjamin A Neely ◽  
Jennifer L Soper ◽  
Denise J Greig ◽  
Kevin P Carlin ◽  
Elizabeth G Favre ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Diagnostic Tool ◽  
Domoic Acid ◽  
California Sea Lions ◽  
Serum Profiling ◽  
Maldi Tof Mass Spectrometry ◽  
Sea Lions ◽  
Maldi Tof ◽  
Domoic Acid Toxicosis

Proteomic analysis of cerebrospinal fluid in California sea lions (Zalophus californianus) with domoic acid toxicosis identifies proteins associated with neurodegeneration

PROTEOMICS ◽  
2015 ◽  
Vol 15 (23-24) ◽  
pp. 4051-4063 ◽  
Author(s):  
Benjamin A. Neely ◽  
Jennifer L. Soper ◽  
Frances M. D. Gulland ◽  
P. Darwin Bell ◽  
Mark Kindy ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Proteomic Analysis ◽  
Domoic Acid ◽  
Zalophus Californianus ◽  
California Sea Lions ◽  
Sea Lions ◽  
Domoic Acid Toxicosis

Magnetic resonance imaging reveals that brain atrophy is more severe in older California sea lions with domoic acid toxicosis

Harmful Algae ◽  
2012 ◽  
Vol 20 ◽  
pp. 19-29 ◽  
Author(s):  
Eric W. Montie ◽  
Elizabeth Wheeler ◽  
Nicola Pussini ◽  
Thomas W.K. Battey ◽  
William Van Bonn ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Brain Atrophy ◽  
Domoic Acid ◽  
Resonance Imaging ◽  
California Sea Lions ◽  
Sea Lions ◽  
Domoic Acid Toxicosis

The Evaluation of Olfaction in Stranded California Sea Lions (Zalophus californianus) and Its Relevance to Domoic Acid Toxicosis

2018 ◽  
Vol 44 (3) ◽  
pp. 231-238
Author(s):  
Lauren M. De Maio ◽  
Peter F. Cook ◽  
Colleen Reichmuth ◽  
Frances M. D. Gulland
Keyword(s):  
Domoic Acid ◽  
Zalophus Californianus ◽  
California Sea Lions ◽  
Sea Lions ◽  
Domoic Acid Toxicosis

scholarly journals Movement, dive behavior, and survival of California sea lions (Zalophus californianus) posttreatment for domoic acid toxicosis

2009 ◽  
Vol 26 (1) ◽  
pp. 36-52 ◽  
Author(s):  
Kate Thomas ◽  
James T. Harvey ◽  
Tracey Goldstein ◽  
Jerome Barakos ◽  
Frances Gulland
Keyword(s):  
Domoic Acid ◽  
Zalophus Californianus ◽  
California Sea Lions ◽  
Dive Behavior ◽  
Sea Lions ◽  
Domoic Acid Toxicosis

scholarly journals Proteomic Analysis of Plasma from California Sea Lions (Zalophus californianus) Reveals Apolipoprotein E as a Candidate Biomarker of Chronic Domoic Acid Toxicosis

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0123295 ◽  
Author(s):  
Benjamin A. Neely ◽  
Jason A. Ferrante ◽  
J. Mauro Chaves ◽  
Jennifer L. Soper ◽  
Jonas S. Almeida ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Proteomic Analysis ◽  
Domoic Acid ◽  
Zalophus Californianus ◽  
California Sea Lions ◽  
Sea Lions ◽  
Domoic Acid Toxicosis

scholarly journals Rapid behavioural diagnosis of domoic acid toxicosis in California sea lions

2011 ◽  
Vol 7 (4) ◽  
pp. 536-538 ◽  
Author(s):  
Peter Cook ◽  
Colleen Reichmuth ◽  
Frances Gulland
Keyword(s):  
Algal Blooms ◽  
Domoic Acid ◽  
Blood Stream ◽  
Neurological Deficits ◽  
Marine Animal ◽  
California Sea Lions ◽  
Sea Lions ◽  
Detection Analysis ◽  
High Doses ◽  
Domoic Acid Toxicosis

Domoic acid is a neurotoxic metabolite of widely occurring algal blooms that has caused multiple marine animal stranding events. Exposure to high doses of domoic acid, a glutamate agonist, may lead to persistent medial temporal seizures and damage to the hippocampus. California sea lions ( Zalophus californianus ) are among the most visible and frequent mammalian victims of domoic acid poisoning, but rapid, reliable diagnosis in a clinical setting has proved difficult owing to the fast clearance of the toxin from the blood stream. Here, we show that the behavioural orienting responses of stranded sea lions diagnosed with domoic acid toxicosis habituate more slowly to a series of non-aversive auditory stimuli than do those of sea lions with no apparent neurological deficits. A signal detection analysis based on these habituation measures was able to correctly identify 50 per cent of subjects with domoic acid toxicosis while correctly rejecting approximately 93 per cent of controls, suggesting potential diagnostic merit.

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