In vitro and in vivo platforms for focused ultrasound-controlled drug delivery and release

2016 ◽  
Vol 139 (4) ◽  
pp. 2092-2092
Author(s):  
Costas Arvanitis
Keyword(s):  
Drug Delivery ◽  
Focused Ultrasound ◽  
Controlled Drug Delivery

scholarly journals Thermo-Sensitive Vesicles in Controlled Drug Delivery for Chemotherapy

Pharmaceutics ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 150 ◽  
Author(s):  
Elisabetta Mazzotta ◽  
Lorena Tavano ◽  
Rita Muzzalupo
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Controlled Drug Delivery ◽  
Solid Tumours ◽  
Site Specific ◽  
Mild Hyperthermia ◽  
Promising Tool ◽  
A Site

Thermo-sensitive vesicles are a promising tool for triggering the release of drugs to solid tumours when used in combination with mild hyperthermia. Responsivity to temperature makes them intelligent nanodevices able to provide a site-specific chemotherapy. Following a brief introduction concerning hyperthermia and its advantageous combination with vesicular systems, recent investigations on thermo-sensitive vesicles useful for controlled drug delivery in cancer treatment are reported in this review. In particular, the influence of bilayer composition on the in vitro and in vivo behaviour of thermo-sensitive formulations currently under investigation have been extensively explored.

Improved in vivo tumor therapy via host–guest complexation

2016 ◽  
Vol 4 (15) ◽  
pp. 2691-2696 ◽  
Author(s):  
Yong Yao ◽  
Yang Wang ◽  
Ruibo Zhao ◽  
Li Shao ◽  
Ruikang Tang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Intracellular Ph ◽  
Tumor Therapy ◽  
Controlled Drug Delivery ◽  
Water Soluble ◽  
Ph Responsive ◽  
Mesoporous Nanoparticles

A decomposable and intracellular pH-responsive drug delivery system by immobilizing a water-soluble pillar[5]arene onto hollow mesoporous nanoparticles through host–guest complexation was successfully prepared and its application in controlled drug delivery in vitro and in vivo was also investigated.

scholarly journals Key Points in Remote-Controlled Drug Delivery: From the Carrier Design to Clinical Trials

2021 ◽  
Vol 22 (17) ◽  
pp. 9149
Author(s):  
Denis V. Voronin ◽  
Anatolii A. Abalymov ◽  
Yulia I. Svenskaya ◽  
Maria V. Lomova
Keyword(s):  
Drug Delivery ◽  
Clinical Trials ◽  
Drug Delivery Systems ◽  
Controlled Drug Delivery ◽  
Delivery Systems ◽  
Optimal Choice ◽  
Research Activity ◽  
Specific Accumulation

The increased research activity aiming at improved delivery of pharmaceutical molecules indicates the expansion of the field. An efficient therapeutic delivery approach is based on the optimal choice of drug-carrying vehicle, successful targeting, and payload release enabling the site-specific accumulation of the therapeutic molecules. However, designing the formulation endowed with the targeting properties in vitro does not guarantee its selective delivery in vivo. The various biological barriers that the carrier encounters upon intravascular administration should be adequately addressed in its overall design to reduce the off-target effects and unwanted toxicity in vivo and thereby enhance the therapeutic efficacy of the payload. Here, we discuss the main parameters of remote-controlled drug delivery systems: (i) key principles of the carrier selection; (ii) the most significant physiological barriers and limitations associated with the drug delivery; (iii) major concepts for its targeting and cargo release stimulation by external stimuli in vivo. The clinical translation for drug delivery systems is also described along with the main challenges, key parameters, and examples of successfully translated drug delivery platforms. The essential steps on the way from drug delivery system design to clinical trials are summarized, arranged, and discussed.

A Closer Look to Polyesters: Properties, Synthesis, Characterization, and Particle Drug Delivery Applications

2020 ◽  
Vol 10 ◽  
Author(s):  
Katherine Pazmiño V. ◽  
Karla Sofía Vizuete ◽  
Frank Alexis ◽  
Brajesh Kumar ◽  
Alexis Debut
Keyword(s):  
Drug Delivery ◽  
Glycolic Acid ◽  
Controlled Drug Delivery ◽  
Polymeric Materials ◽  
Synthetic Polymers ◽  
Future Application ◽  
In Vivo Tests ◽  
Drug Delivery Applications

Background: Natural and synthetic polymeric materials can be used in the fields of biomedicine and pharmaceuticals as a material for controlled drug delivery. Among the synthetic polymers, polyesters are synthesized from two natural monomers: lactic and glycolic acid, which are biocompatible and biodegradable. Objective: Here we review broad aspects of polyesters including its properties, synthesis, characterization, and particle drug delivery applications. Conclusion: Finally, we have concluded that polyesters are certainly very versatile material that is continuously reinvented for future application in new areas of science and medicine. However, several aspects must be considered when synthesizing polyesters, which have a direct influence on biodegradability and biocompatibility. These properties may limit the performance of in vitro and in vivo tests.

In vitro and in vivo evaluation of novel implantation technology in hydrogel contact lenses for controlled drug delivery

2016 ◽  
Vol 226 ◽  
pp. 47-56 ◽  
Author(s):  
Furqan A. Maulvi ◽  
Dhara H. Lakdawala ◽  
Anjum A. Shaikh ◽  
Ankita R. Desai ◽  
Harsh H. Choksi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Contact Lenses ◽  
Controlled Drug Delivery ◽  
In Vivo Evaluation
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