scholarly journals Thermo-Sensitive Vesicles in Controlled Drug Delivery for Chemotherapy

Pharmaceutics ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 150 ◽  
Author(s):  
Elisabetta Mazzotta ◽  
Lorena Tavano ◽  
Rita Muzzalupo
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Controlled Drug Delivery ◽  
Solid Tumours ◽  
Site Specific ◽  
Mild Hyperthermia ◽  
Promising Tool ◽  
A Site

Thermo-sensitive vesicles are a promising tool for triggering the release of drugs to solid tumours when used in combination with mild hyperthermia. Responsivity to temperature makes them intelligent nanodevices able to provide a site-specific chemotherapy. Following a brief introduction concerning hyperthermia and its advantageous combination with vesicular systems, recent investigations on thermo-sensitive vesicles useful for controlled drug delivery in cancer treatment are reported in this review. In particular, the influence of bilayer composition on the in vitro and in vivo behaviour of thermo-sensitive formulations currently under investigation have been extensively explored.

In vitro and in vivo evaluation of an oral system for time and/or site-specific drug delivery

2001 ◽  
Vol 73 (1) ◽  
pp. 103-110 ◽  
Author(s):  
M.E Sangalli ◽  
A Maroni ◽  
L Zema ◽  
C Busetti ◽  
F Giordano ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Specific Drug ◽  
In Vivo Evaluation ◽  
Site Specific

Redox Sensitive Polysaccharide Based Nanoparticles for Improved Cancer Treatment: A Comprehensive Review

2018 ◽  
Vol 24 (28) ◽  
pp. 3303-3319 ◽  
Author(s):  
Erfaneh Ghassami ◽  
Jaleh Varshosaz ◽  
Somayeh Taymouri
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Chemical Properties ◽  
Delivery Systems ◽  
Exchange Reactions ◽  
Triggered Release ◽  
Redox Responsive

Background: Among the numerous bio-responsive polymeric drug delivery systems developed recently, redox-triggered release of molecular payloads have gained great deal of attention, especially in the field of anticancer drug delivery. In most cases, these systems rely on disulfide bonds located either in the matrix crosslinks, or in auxiliary chains to achieve stimuli-responsive drug release. These bonds keep their stability in extracellular environments, yet, rapidly break by thiol–disulfide exchange reactions in the cytosol, due to the presence of greater levels of glutathione. Polysaccharides are macromolecules with low cost, natural abundance, biocompatibility, biodegradability, appropriate physical and chemical properties, and presence of numerous functional groups which facilitate chemical or physical cross-linking. Methods: With regards to the remarkable advantages of polysaccharides, in the current study, various polysaccharide-based redox-responsive drug delivery systems are reviewed. In most cases the in vitro/in vivo effects of the developed system were also evaluated. Results: Considering the hypoxic and reducing nature of the tumor microenvironment, with several folds higher glutathione levels than the systemic tissues, redox-sensitive polymeric systems could be implemented for tumorspecific drug delivery and the results of the previous researches in this field indicated satisfactory achievements. Conclusion: According to the reviewed papers, the efficiency of diverse redox-responsive polysaccharide-based nanoparticles with therapeutic payloads in cancer chemotherapy could be concluded. Nevertheless, more comprehensive studies are required to understand the exact intracellular and systemic fate of these nano-carriers, as well as their clinical efficacy for cancer treatment.

scholarly journals Novel Surface Modification of ZnO QDs for Paclitaxel-Targeted Drug Delivery for Lung Cancer Treatment

Dose-Response ◽  
2020 ◽  
Vol 18 (2) ◽  
pp. 155932582092673
Author(s):  
Chuan Xie ◽  
Yan Zhan ◽  
Peng Wang ◽  
Bo Zhang ◽  
Yukun Zhang
Keyword(s):  
Drug Delivery ◽  
Surface Modification ◽  
Cancer Treatment ◽  
Drug Delivery System ◽  
Delivery System ◽  
High Efficiency ◽  
A549 Cells ◽  
Cytotoxicity Studies

Adipic dihydrazide and heparin were attached to ZnO quantum dots surface, and the ZnO-adipic dihydrazide-heparin nanocomplex was used as a drug delivery system to deliver paclitaxel for chemotherapy. The surface modification and the loading of paclitaxel were confirmed by Fourier transform infrared spectrum, featured by characteristic peaks from functional groups of adipic dihydrazide, heparin, and paclitaxel. The impacts of pH on the drug release were investigated, and the cytotoxicity studies were conducted with A549 cells. The pharmacokinetic study was conducted with male Wistar rats. Both in vitro and in vivo study indicated that ZnO-adipic dihydrazide-heparin-paclitaxel nanocomplex could deliver paclitaxel in a more controllable way, and it has the potential to be a high-efficiency drug delivery system for cancer treatment.

Improved in vivo tumor therapy via host–guest complexation

2016 ◽  
Vol 4 (15) ◽  
pp. 2691-2696 ◽  
Author(s):  
Yong Yao ◽  
Yang Wang ◽  
Ruibo Zhao ◽  
Li Shao ◽  
Ruikang Tang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Intracellular Ph ◽  
Tumor Therapy ◽  
Controlled Drug Delivery ◽  
Water Soluble ◽  
Ph Responsive ◽  
Mesoporous Nanoparticles

A decomposable and intracellular pH-responsive drug delivery system by immobilizing a water-soluble pillar[5]arene onto hollow mesoporous nanoparticles through host–guest complexation was successfully prepared and its application in controlled drug delivery in vitro and in vivo was also investigated.

scholarly journals Investigations of human myosin VI targeting using optogenetically controlled cargo loading

2017 ◽  
Vol 114 (9) ◽  
pp. E1607-E1616 ◽  
Author(s):  
Alexander R. French ◽  
Tobin R. Sosnick ◽  
Ronald S. Rock
Keyword(s):  
Avena Sativa ◽  
Activation Mechanism ◽  
Myosin Vi ◽  
Site Specific ◽  
Specific Location ◽  
Cargo Protein ◽  
Specific Manner ◽  
A Site

Myosins play countless critical roles in the cell, each requiring it to be activated at a specific location and time. To control myosin VI with this specificity, we created an optogenetic tool for activating myosin VI by fusing the light-sensitive Avena sativa phototropin1 LOV2 domain to a peptide from Dab2 (LOVDab), a myosin VI cargo protein. Our approach harnesses the native targeting and activation mechanism of myosin VI, allowing direct inferences on myosin VI function. LOVDab robustly recruits human full-length myosin VI to various organelles in vivo and hinders peroxisome motion in a light-controllable manner. LOVDab also activates myosin VI in an in vitro gliding filament assay. Our data suggest that protein and lipid cargoes cooperate to activate myosin VI, allowing myosin VI to integrate Ca2+, lipid, and protein cargo signals in the cell to deploy in a site-specific manner.

scholarly journals Key Points in Remote-Controlled Drug Delivery: From the Carrier Design to Clinical Trials

2021 ◽  
Vol 22 (17) ◽  
pp. 9149
Author(s):  
Denis V. Voronin ◽  
Anatolii A. Abalymov ◽  
Yulia I. Svenskaya ◽  
Maria V. Lomova
Keyword(s):  
Drug Delivery ◽  
Clinical Trials ◽  
Drug Delivery Systems ◽  
Controlled Drug Delivery ◽  
Delivery Systems ◽  
Optimal Choice ◽  
Research Activity ◽  
Specific Accumulation

The increased research activity aiming at improved delivery of pharmaceutical molecules indicates the expansion of the field. An efficient therapeutic delivery approach is based on the optimal choice of drug-carrying vehicle, successful targeting, and payload release enabling the site-specific accumulation of the therapeutic molecules. However, designing the formulation endowed with the targeting properties in vitro does not guarantee its selective delivery in vivo. The various biological barriers that the carrier encounters upon intravascular administration should be adequately addressed in its overall design to reduce the off-target effects and unwanted toxicity in vivo and thereby enhance the therapeutic efficacy of the payload. Here, we discuss the main parameters of remote-controlled drug delivery systems: (i) key principles of the carrier selection; (ii) the most significant physiological barriers and limitations associated with the drug delivery; (iii) major concepts for its targeting and cargo release stimulation by external stimuli in vivo. The clinical translation for drug delivery systems is also described along with the main challenges, key parameters, and examples of successfully translated drug delivery platforms. The essential steps on the way from drug delivery system design to clinical trials are summarized, arranged, and discussed.

A Closer Look to Polyesters: Properties, Synthesis, Characterization, and Particle Drug Delivery Applications

2020 ◽  
Vol 10 ◽  
Author(s):  
Katherine Pazmiño V. ◽  
Karla Sofía Vizuete ◽  
Frank Alexis ◽  
Brajesh Kumar ◽  
Alexis Debut
Keyword(s):  
Drug Delivery ◽  
Glycolic Acid ◽  
Controlled Drug Delivery ◽  
Polymeric Materials ◽  
Synthetic Polymers ◽  
Future Application ◽  
In Vivo Tests ◽  
Drug Delivery Applications

Background: Natural and synthetic polymeric materials can be used in the fields of biomedicine and pharmaceuticals as a material for controlled drug delivery. Among the synthetic polymers, polyesters are synthesized from two natural monomers: lactic and glycolic acid, which are biocompatible and biodegradable. Objective: Here we review broad aspects of polyesters including its properties, synthesis, characterization, and particle drug delivery applications. Conclusion: Finally, we have concluded that polyesters are certainly very versatile material that is continuously reinvented for future application in new areas of science and medicine. However, several aspects must be considered when synthesizing polyesters, which have a direct influence on biodegradability and biocompatibility. These properties may limit the performance of in vitro and in vivo tests.

scholarly journals Multifunctional nanoplatforms as cascade-responsive drug-delivery carriers for effective synergistic chemo-photodynamic cancer treatment

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Fan Li ◽  
Yan Liang ◽  
Miaochen Wang ◽  
Xing Xu ◽  
Fen Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Cancer Treatment ◽  
Blood Circulation ◽  
The Novel ◽  
Hydrophobic Core ◽  
Cancer Suppression ◽  
532 Nm

AbstractSynergistic chemo-photodynamic therapy has garnered attention in the field of cancer treatment. Here, a pH cascade-responsive micellar nanoplatform with nucleus-targeted ability, for effective synergistic chemo-photodynamic cancer treatment, was fabricated. In this micellar nanoplatform, 5-(4-carboxyphenyl)-10,15,20-triphenylporphyrin (Por), a photodynamic therapy (PDT) agent was utilized for carrying the novel anticancer drug GNA002 to construct a hydrophobic core, and cyclic RGD peptide (cRGD)-modified polyethylene glycol (PEG) (cRGD-PEG) connected the cell-penetrating peptide hexaarginine (R6) through a pH-responsive hydrazone bond (cRGD-PEG-N = CH-R6) to serve as a hydrophilic shell for increasing blood circulation time. After passively accumulating in tumor sites, the self-assembled GNA002-loaded nanoparticles were actively internalized into cancer cells via the cRGD ligands. Once phagocytosed by lysosomes, the acidity-triggered detachment of the cRGD-PEG shell led to the formation of R6-coated secondary nanoparticles and subsequent R6-mediated nucleus-targeted drug delivery. Combined with GNA002-induced nucleus-specific chemotherapy, reactive oxygen species produced by Por under 532-nm laser irradiation achieved a potent synergistic chemo-photodynamic cancer treatment. Moreover, our in vitro and in vivo anticancer investigations revealed high cancer-suppression efficacy of this ideal multifunctional nanoplatform, indicating that it could be a promising candidate for synergistic anticancer therapy.

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