Cardiorespiratory Fitness Among Individuals With Psoriasis in the General Population

2016 ◽  
Vol 13 (7) ◽  
pp. 771-775 ◽  
Author(s):  
Patrick B. Wilson
Keyword(s):  
Physical Activity ◽  
General Population ◽  
Surface Area ◽  
Body Surface Area ◽  
Cardiorespiratory Fitness ◽  
Body Surface ◽  
Secondary Data ◽  
Limited Data ◽  
Cardiometabolic Disorders ◽  
Psoriasis Severity

Background:Psoriasis confers risk for cardiometabolic disorders. Cardiorespiratory fitness is inversely associated with risk of cardiometabolic disorders in other populations, but limited data have been published assessing cardiorespiratory fitness among individuals with psoriasis. This investigation aimed to: 1) assess cardiorespiratory fitness among individuals with psoriasis in the general population; and 2) compare levels to individuals without psoriasis.Methods:A secondary data analysis from the 2003–2004 National Health and Nutritional Examination Survey was performed. Cardiorespiratory fitness was assessed with a treadmill test, while measures of psoriasis severity included rating of psoriasis as a life problem and body surface area involvement.Results:Twenty-six of 1093 participants reported a psoriasis diagnosis (population weighted prevalence 2.9%). Individuals with psoriasis had lower cardiorespiratory fitness compared with individuals without psoriasis (36.2 vs. 39.1 mL∙kg-1∙min-1, P = .009). No differences in self-reported or accelerometer physical activity were found by psoriasis diagnosis. Cardiorespiratory fitness was not significantly lower in those reporting high life impairment or body surface area involvement.Conclusions:Cardiorespiratory fitness may be lower in individuals with psoriasis and these differences may not be explained by self-reported disease severity measures or physical activity. Future studies should examine whether validated measures of psoriasis severity predict lower cardiorespiratory fitness.

Sex differences and higher upper normal limits for left atrial end-systolic volume in individuals in their mid-60s: data from the ACE 1950 Study

2020 ◽  
Vol 21 (5) ◽  
pp. 501-507 ◽  
Author(s):  
Peter Selmer Rønningen ◽  
Trygve Berge ◽  
Magnar Gangås Solberg ◽  
Steve Enger ◽  
Ståle Nygård ◽  
...  
Keyword(s):  
Sex Differences ◽  
General Population ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Left Atrial ◽  
Normal Range ◽  
Healthy Group ◽  
Systolic Volume ◽  
Normal Limits

Abstract Aims The current study aimed to describe normal values of left atrial (LA) volumes and LA emptying fraction (LAEF) in a large sample in their mid-60s from the general population and to explore sex differences. Methods and results In the Akershus Cardiac Examination (ACE) 1950 Study, body surface area-indexed LA maximum (LAVimax) and minimum (LAVimin) volumes and LAEF were measured in 3489 individuals aged 63.9 ± 0.6 years from the general population. A healthy group of 832 individuals was defined. Data are presented as mean ± standard deviation (SD) and a normal range of mean ± 2 SD. T-tests were used for comparisons. In the healthy group, mean LAVimax was 25.5 ± 6.2 mL/m2 and the normal range was 13.1–37.9 mL/m2. Men had significantly larger body surface area-indexed volumes than women, but there was no difference in LAEF. The mean LAVimax for healthy men was 26.4 ± 6.5 mL/m2, for healthy women 24.9 ± 5.8 mL/m2 (P < 0.001) and the upper normal limits were 39.4 and 36.5 mL/m2, respectively. In the healthy group, 13.0% of all men and 5.4% of all women had LAVimax above the current upper normal limit of 34 mL/m2. Conclusion A large proportion of healthy individuals, in particular men, had LAVimax >34 mL/m2. Our findings suggest that the recommended cut-off may be too low at the age of 65 years and above and that sex-specific cut-offs should be considered.

Body surface area affected by psoriasis and the risk for psoriatic arthritis: a prospective population-based cohort study

Rheumatology ◽  
2021 ◽  
Author(s):  
Alexis Ogdie ◽  
Daniel B Shin ◽  
Thorvardur Jon Love ◽  
Joel M Gelfand
Keyword(s):  
Cohort Study ◽  
Psoriatic Arthritis ◽  
Surface Area ◽  
Body Surface Area ◽  
General Practitioners ◽  
Body Surface ◽  
Strong Predictor ◽  
Population Based ◽  
Health Improvement ◽  
Psoriasis Severity

Abstract Objective Increasing psoriasis severity has been associated with comorbidities including cardiovascular disease. The objective of this study was to examine the association of psoriasis severity with the development of psoriatic arthritis (PsA). Methods A prospective population-based cohort study was performed within The Health Improvement Network, a United Kingdom medical record database. Patients aged 25–60 years with a code for psoriasis were randomly selected between 2008–2011. Questionnaires were sent to their general practitioners to confirm the diagnosis of psoriasis and provide the patient’s approximate body surface area (BSA). Incidence of PsA was calculated by BSA, and Cox proportional hazard ratios were used to examine the risk of developing PsA by BSA category after adjusting for other covariates. Results Among 10 474 questionnaires sent, 9,987 (95%) were returned, 9,069 (91%) had confirmed psoriasis, and BSA was provided for 8,881 patients: 52% had mild psoriasis, 36% moderate psoriasis, and 12% severe psoriasis. The mean age was 46, and 49% were female. Mean follow-up time was 4.2 years (SD 2.1); the incidence of PsA was 5.4 cases per 1,000 person years. After adjusting for age and sex, BSA >10% (HR 2.01, 95% CI: 1.29–3.13), BSA 3–10% (HR 1.44, 95% CI: 1.02–2.03), obesity (HR 1.64, 95% CI: 1.19–2.26), and depression (HR 1.68, 95% CI: 1.21–2.33) were associated with incident PsA. Conclusions In this large prospective cohort study, BSA assessed by general practitioners was a strong predictor of developing PsA, and obesity and depression were additive risk factors.

scholarly journals Normal values of aortic dimensions assessed by multidetector computed tomography in the Copenhagen General Population Study

2019 ◽  
Vol 20 (8) ◽  
pp. 939-948 ◽  
Author(s):  
Michael H C Pham ◽  
Christian Ballegaard ◽  
Martina C de Knegt ◽  
Per E Sigvardsen ◽  
Mathias H Sørgaard ◽  
...  
Keyword(s):  
Computed Tomography ◽  
General Population ◽  
Surface Area ◽  
Body Surface Area ◽  
Abdominal Aorta ◽  
Body Surface ◽  
Normal Values ◽  
General Population Study ◽  
Contrast Enhanced ◽  
Aortic Dimensions

Abstract Aims Accurate assessment of aortic dimensions can be achieved using contrast-enhanced computed tomography. The aim of this study was to define normal values and determinants of aortic dimensions throughout multiple key anatomical landmarks of the aorta in healthy individuals from the Copenhagen General Population Study. Methods and results The study group consisted of 902 healthy subjects selected from 3000 adults undergoing cardiovascular thoracic and abdominal computed tomography-angiography (CTA), where systematic measurements of aortic dimensions were performed retrospectively. Individuals included were without any of the following predefined cardiovascular risk factors: (i) self-reported angina pectoris; (ii) hypertension; (iii) hypercholesterolaemia; (iv) taking cardiovascular prescribed medication including diuretics, statins, or aspirin; (v) overweight (defined as body mass index ≥30 kg/m2); (vi) diabetes mellitus (self-reported or blood glucose >8 mmol/L); and (vii) chronic obstructive pulmonary disease. Maximal aortic diameters were measured at seven aortic regions: sinuses of Valsalva, sinotubular junction, ascending aorta, mid-descending aorta, abdominal aorta at the diaphragm, abdominal aorta at the coeliac trunk, and infrarenal abdominal aorta. Median age was 52 years, and 396 (40%) were men. Men had significantly larger aortic diameters at all levels compared with women (P < 0.001). Multivariable analysis revealed that sex, age, and body surface area were associated with increasing aortic dimensions. Conclusion Normal values of maximal aortic dimensions at key aortic anatomical locations by contrast-enhanced CTA have been defined. Age, sex, and body surface area were significantly associated with these measures at all levels of aorta. Aortic dimensions follow an almost identical pattern throughout the vessel regardless of sex.

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