Estrogen Receptor α Polymorphism Modifies the Association between Childhood Exercise and Bone Mass: Follow-Up Study

2007 ◽  
Vol 19 (4) ◽  
pp. 444-458 ◽  
Author(s):  
Miia Suuriniemi ◽  
Harri Suominen ◽  
Anitta Mahonen ◽  
Markku Alén ◽  
Sulin Cheng
Keyword(s):  
Physical Activity ◽  
Bone Mineral Density ◽  
Bone Mass ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Areal Bone Mineral Density ◽  
Mineral Density ◽  
Follow Up Study

This follow-up study confirms our previous findings that the ER-α PvuII polymorphism (Pp) modulates the association between exercise and bone mass. The differences in bone properties of girls with consistently low physical activity (LLPA) and consistently high physical activity (HHPA) were evident only in those bearing the heterozygote ER-α genotype (Pp). In particular, areal bone mineral density of the total femur, bone mineral content and areal bone mineral density of the femoral neck, and bone mineral content and cortical thickness of the tibia shaft were significantly (p < .05) lower in the Pp girls with LLPA than in their HHPA counterparts. These findings might partly explain the genetic basis of human variation associated with exercise training.

scholarly journals Skeletal Benefits of Pre-Menarcheal Gymnastics Are Retained After Activity Cessation

2010 ◽  
Vol 22 (1) ◽  
pp. 21-33 ◽  
Author(s):  
Tamara A. Scerpella ◽  
Jodi N. Dowthwaite ◽  
Nicole M. Gero ◽  
Jill A. Kanaley ◽  
Robert J. Ploutz-Snyder
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral Content ◽  
Mechanical Loading ◽  
Bone Mineral ◽  
Mineral Content ◽  
Additional Benefit ◽  
Areal Bone Mineral Density ◽  
Childhood And Adolescence ◽  
Mineral Density ◽  
Projected Area

Mechanical loading during childhood and adolescence may yield skeletal benefits that persist beyond activity cessation and menarche. At 1 year pre- and 2 years post-menarche, nondominant forearm areal bone mineral density (aBMD), bone mineral content (BMC) and projected area (area) were compared in gymnasts (n = 9), ex-gymnasts (n = 8) and nongymnasts (n = 13). At both observations, gymnasts and ex-gymnasts had higher forearm aBMD, BMC and area than nongymnasts. gymnasts had higher postmenarcheal means than ex-gymnasts for all three parameters. Childhood mechanical loading yields skeletal advantages that persist at least 24 months after loading cessation and menarche. Continued postmenarcheal loading yields additional benefit.

Effects of tower climbing exercise on bone mass, strength, and turnover in orchidectomized growing rats

2002 ◽  
Vol 93 (3) ◽  
pp. 1152-1158 ◽  
Author(s):  
Takuya Notomi ◽  
Yuichi Okazaki ◽  
Nobukazu Okimoto ◽  
Yuri Tanaka ◽  
Toshitaka Nakamura ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Formation ◽  
Bone Mass ◽  
Bone Mineral Content ◽  
Trabecular Bone ◽  
Bone Mineral ◽  
Mineral Content ◽  
Lumbar Vertebrae ◽  
Mineral Density ◽  
Sedentary Group

To determine the effects of a tower climbing exercise on mass, strength, and local turnover of bone, 70 9-wk-old Sprague-Dawley rats were assigned to seven groups: a baseline control and three groups of sham-operated sedentary, orchidectomized (ORX)-sedentary and ORX-exercise rats. Rats voluntarily climbed a 200-cm tower to drink water from a bottle set at the top. At 4 wk, the periosteal bone formation rate (BFR), moment of inertia, bone mineral content, bone mineral density, and bending load at the midfemur were maintained in ORX-exercise rats, whereas these parameters were reduced in ORX-sedentary rats. At 8 wk, the periosteal mineral apposition rate and BFR in ORX-exercise rats were significantly higher, whereas the parameters in ORX-sedentary rats did not differ compared with sham-sedentary rats. In ORX-exercise rats, the trabecular mineralizing surface, BFR, and bone volume of the lumbar vertebrae were maintained at the same levels as those in the sham-sedentary group, whereas the osteoclast surface decreased compared with the ORX-sedentary group. However, the climbing exercise did not affect bone mineral content, bone mineral density, or the compression load of the lumbar vertebrae. These results show that, in the midfemur, the voluntary climbing exercise maintained cortical bone mass and strength by stimulating periosteal bone formation and partially prevented ORX-induced trabecular bone loss, depressing the elevation of turnover. Interestingly, in ORX rats, the climbing exercise had the opposite effect on bone formation at the periosteal femoral cortical bone, where the exercise increased the bone formation compared with vertebral trabecular bone, where the exercise decreased it.

scholarly journals Anthropometric models of bone mineral content and areal bone mineral density based on the bone mineral density in childhood study

2014 ◽  
Vol 26 (3) ◽  
pp. 1099-1108 ◽  
Author(s):  
D. F. Short ◽  
V. Gilsanz ◽  
H. J. Kalkwarf ◽  
J. M. Lappe ◽  
S. Oberfield ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral Content ◽  
Bone Mineral ◽  
Mineral Content ◽  
Areal Bone Mineral Density ◽  
Mineral Density

scholarly journals Bone mineral density acquisition in peripubertal female rhythmic gymnasts is directly associated with plasma IGF1/IGF-binding protein 3 ratio

2010 ◽  
Vol 163 (1) ◽  
pp. 157-164 ◽  
Author(s):  
Laurent Maïmoun ◽  
Olivier Coste ◽  
Florence Galtier ◽  
Thibault Mura ◽  
Denis Mariano-Goulart ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mass ◽  
Bone Mineral ◽  
Whole Body ◽  
Mineral Density ◽  
Follow Up Study ◽  
Igf Binding ◽  
Igf Binding Protein ◽  
Rhythmic Gymnasts

ObjectivesIntense physical activity in peripubertal girls may delay menarche and cause menstrual disorders and estrogen deficiency, particularly in sport disciplines that require strict weight control. It may also have a deleterious effect on bone mass acquisition. The aim of this study was to determine the time-course of bone mass accretion in peripubertal elite female rhythmic gymnasts (FRGs) over a 1-year period, as well as the anthropometric and hormone parameters that could be helpful for predicting bone mineral density (BMD) gain.Methods and designWe conducted a 1-year follow-up study in 29 FRGs (10.7–16.1 years old). Whole body composition and BMD of the whole body, proximal femur, lumbar spine, mid-radius, and skull were measured by dual energy X-ray absorptiometry (DXA). Moreover, baseline growth- and bone metabolism-related hormones such as IGF1, IGF-binding protein 3 (IGFBP3), leptin, and bone markers were measured.ResultsBMD increased significantly at all bone sites throughout puberty, particularly between Tanner stages II and IV–V (P=0.025 to P<0.001). The IGF1 level, IGF1/IGFBP3 ratio, and leptin level were higher in late pubertal stages (i.e. IV–V) compared with early stage (i.e. I). In simple and multivariate analyses, only the IGF1/IGFBP3 ratio was strongly correlated with the BMD change at all bone sites (r=0.49, P=0.02 to r=0.77, P<0.0001).ConclusionThis 1-year follow-up study of peripubertal FRGs showed that BMD gain was maximal around Tanner stage III. The plasma IGF1/IGFBP3 ratio was associated with bone mass acquisition in this period, and it may thus serve as a surrogate marker of bone mass gain in this population.

Prediction of Areal Bone Mineral Density and Bone Mineral Content in Children and Adolescents Living With HIV Based on Anthropometric Variables

2016 ◽  
Vol 19 (4) ◽  
pp. 457-464 ◽  
Author(s):  
Luiz Rodrigo Augustemak de Lima ◽  
Rodrigo de Rosso Krug ◽  
Rosane Carla Rosendo da Silva ◽  
Aroldo Prohmann de Carvalho ◽  
David Alejandro González-Chica ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral Content ◽  
Children And Adolescents ◽  
Bone Mineral ◽  
Mineral Content ◽  
Areal Bone Mineral Density ◽  
Mineral Density ◽  
Living With Hiv
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