Functional ATP-Binding Cassette Drug Efflux Transporters in Isolated Human and Rat Hepatocytes Significantly Affect Assessment of Drug Disposition

2014 ◽  
Vol 42 (3) ◽  
pp. 448-458 ◽  
Author(s):  
Patrik Lundquist ◽  
Gunilla Englund ◽  
Cristine Skogastierna ◽  
Johan Lööf ◽  
Jenny Johansson ◽  
...  
Keyword(s):  
Drug Disposition ◽  
Rat Hepatocytes ◽  
Efflux Transporters ◽  
Atp Binding ◽  
Drug Efflux ◽  
Drug Efflux Transporters ◽  
Atp Binding Cassette

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview

2012 ◽  
Vol 64 ◽  
pp. 138-153 ◽  
Author(s):  
Alfred H. Schinkel ◽  
Johan W. Jonker
Keyword(s):  
Efflux Transporters ◽  
Atp Binding ◽  
Drug Efflux ◽  
Drug Efflux Transporters ◽  
Atp Binding Cassette

scholarly journals Interactions of Alectinib with Human ATP-Binding Cassette Drug Efflux Transporters and Cytochrome P450 Biotransformation Enzymes: Effect on Pharmacokinetic Multidrug Resistance

2019 ◽  
Vol 47 (7) ◽  
pp. 699-709 ◽  
Author(s):  
Jakub Hofman ◽  
Ales Sorf ◽  
Dimitrios Vagiannis ◽  
Simona Sucha ◽  
Eva Novotna ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Multidrug Resistance ◽  
Efflux Transporters ◽  
Atp Binding ◽  
Drug Efflux ◽  
Biotransformation Enzymes ◽  
Drug Efflux Transporters ◽  
Atp Binding Cassette

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade

2016 ◽  
Vol 370 (1) ◽  
pp. 153-164 ◽  
Author(s):  
Zhaolin Chen ◽  
Tianlu Shi ◽  
Lei Zhang ◽  
Pengli Zhu ◽  
Mingying Deng ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Efflux Transporters ◽  
Atp Binding ◽  
Drug Efflux ◽  
The Past ◽  
Drug Efflux Transporters ◽  
Atp Binding Cassette

Transport of ribavirin across the rat and human placental barrier: Roles of nucleoside and ATP-binding cassette drug efflux transporters

2019 ◽  
Vol 163 ◽  
pp. 60-70 ◽  
Author(s):  
S. Karbanova ◽  
L. Cerveny ◽  
L. Jiraskova ◽  
R. Karahoda ◽  
M. Ceckova ◽  
...  
Keyword(s):  
Efflux Transporters ◽  
Atp Binding ◽  
Drug Efflux ◽  
Placental Barrier ◽  
Drug Efflux Transporters ◽  
Atp Binding Cassette

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview

2003 ◽  
Vol 55 (1) ◽  
pp. 3-29 ◽  
Author(s):  
Alfred H Schinkel ◽  
Johan W Jonker
Keyword(s):  
Efflux Transporters ◽  
Atp Binding ◽  
Drug Efflux ◽  
Drug Efflux Transporters ◽  
Atp Binding Cassette

Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases

2005 ◽  
Vol 76 (1) ◽  
pp. 22-76 ◽  
Author(s):  
Wolfgang Löscher ◽  
Heidrun Potschka
Keyword(s):  
Drug Disposition ◽  
Brain Diseases ◽  
Efflux Transporters ◽  
Drug Efflux ◽  
The Brain ◽  
Drug Efflux Transporters

scholarly journals THE MODULATION OF DRUG EFFLUX TRANSPORTER BY CURCUMIN IN MCF7 BREAST CANCER CELLS AFTER REPEATED EXPOSURE OF ENDOXIFEN AND ESTRADIOL

2018 ◽  
Vol 10 (1) ◽  
pp. 102
Author(s):  
Robby Hertanto ◽  
Wilson Bastian ◽  
Paramita . ◽  
Melva Louisa
Keyword(s):  
Breast Cancer ◽  
Cell Viability ◽  
Mrna Expression ◽  
Rna Extraction ◽  
Efflux Transporters ◽  
Drug Efflux ◽  
Mcf7 Cells ◽  
Total Rna ◽  
P Glycoprotein ◽  
Drug Efflux Transporters

Objective: The aim of the present study was to determine whether curcumin (CM) can prevent drug sensitivity of breast cancer (BC) cells when E andβ-E2 are administered together and whether the underlying mechanism involves modulation of drug efflux transporters.Methods: MCF7 BC cells were treated with the vehicle only, E+β-E2, or E+β-E2+CM repeatedly for 8 weeks. Afterward, the cells were harvested,counted, and isolated for total RNA extraction. Total RNA was then processed into cDNA and further processed for the determination of mRNAexpression patterns of drug efflux transporters (P-glycoprotein, BCRP, and MRP1).Results: Decreased sensitivity of BC cells was shown by the increased cell viability of MCF7 cells after 8 weeks. This condition was accompanied withincreased mRNA expression of P-glycoprotein, BCRP, and MRP1 in cells treated with E+β-E2, as compared with the vehicle only. CM, administered incombination with E+β-E2, resulted in decreased cell viability versus E and β-E2 and also decreased in mRNA expression of P-glycoprotein, BCRP, andMRP1.Conclusion: CM partially reversed the sensitivity loss of BC cells to E in the presence of β-E2 by modulating drug efflux transporters.

Quantitative Assessment of HIV-1 Protease Inhibitor Interactions with Drug Efflux Transporters in the Blood–Brain Barrier

2005 ◽  
Vol 22 (8) ◽  
pp. 1259-1268 ◽  
Author(s):  
Corbin J. Bachmeier ◽  
Timothy J. Spitzenberger ◽  
William F. Elmquist ◽  
Donald W. Miller
Keyword(s):  
Protease Inhibitor ◽  
Blood Brain Barrier ◽  
Quantitative Assessment ◽  
Brain Barrier ◽  
Efflux Transporters ◽  
Drug Efflux ◽  
Blood Brain ◽  
Hiv 1 ◽  
Drug Efflux Transporters

Expression of drug efflux transporters in poultry tissues

2010 ◽  
Vol 89 (1) ◽  
pp. 104-107 ◽  
Author(s):  
Aneliya M. Haritova ◽  
J. Schrickx ◽  
Johanna Fink-Gremmels
Keyword(s):  
Efflux Transporters ◽  
Drug Efflux ◽  
Poultry Tissues ◽  
Drug Efflux Transporters
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