Negative Regulation of Human Hepatic Constitutive Androstane Receptor by Cholesterol Synthesis Inhibition: Role of Sterol Regulatory Element Binding Proteins

2021 ◽  
pp. DMD-AR-2020-000341
Author(s):  
Liberta Cuko ◽  
Zofia Duniec-Dmuchowski ◽  
Elizabeth A. Rondini ◽  
Asmita Pant ◽  
John K. Fallon ◽  
...  
Keyword(s):  
Cholesterol Synthesis ◽  
Binding Proteins ◽  
Regulatory Element ◽  
Constitutive Androstane Receptor ◽  
Negative Regulation ◽  
Synthesis Inhibition ◽  
Sterol Regulatory Element

scholarly journals Role of Sterol Regulatory Element Binding Proteins in the Regulation of Gα i2 Expression in Cultured Atrial Cells

2002 ◽  
Vol 91 (1) ◽  
pp. 32-37 ◽  
Author(s):  
Ho-Jin Park ◽  
Ulrike Begley ◽  
Dequan Kong ◽  
Haiyan Yu ◽  
Liya Yin ◽  
...  
Keyword(s):  
Binding Proteins ◽  
Regulatory Element ◽  
Atrial Cells ◽  
Sterol Regulatory Element

Sterol Regulatory Element-Binding Proteins Induce an Entire Pathway of Cholesterol Synthesis

2001 ◽  
Vol 287 (1) ◽  
pp. 311 ◽  
Author(s):  
Yuki Sakakura ◽  
Hitoshi Shimano ◽  
Hirohito Sone ◽  
Akimitsu Takahashi ◽  
Kuniyuki Inoue ◽  
...  
Keyword(s):  
Cholesterol Synthesis ◽  
Binding Proteins ◽  
Regulatory Element ◽  
Sterol Regulatory Element

scholarly journals Retrospective on Cholesterol Homeostasis: The Central Role of Scap

2018 ◽  
Vol 87 (1) ◽  
pp. 783-807 ◽  
Author(s):  
Michael S. Brown ◽  
Arun Radhakrishnan ◽  
Joseph L. Goldstein
Keyword(s):  
Conformational Changes ◽  
Mammalian Cells ◽  
Cholesterol Synthesis ◽  
Regulatory Element ◽  
Cholesterol Content ◽  
Proteolytic Processing ◽  
Cholesterol Homeostasis ◽  
Sterol Regulatory Element ◽  
Polytopic Membrane Protein

Scap is a polytopic membrane protein that functions as a molecular machine to control the cholesterol content of membranes in mammalian cells. In the 21 years since our laboratory discovered Scap, we have learned how it binds sterol regulatory element-binding proteins (SREBPs) and transports them from the endoplasmic reticulum (ER) to the Golgi for proteolytic processing. Proteolysis releases the SREBP transcription factor domains, which enter the nucleus to promote cholesterol synthesis and uptake. When cholesterol in ER membranes exceeds a threshold, the sterol binds to Scap, triggering several conformational changes that prevent the Scap–SREBP complex from leaving the ER. As a result, SREBPs are no longer processed, cholesterol synthesis and uptake are repressed, and cholesterol homeostasis is restored. This review focuses on the four domains of Scap that undergo concerted conformational changes in response to cholesterol binding. The data provide a molecular mechanism for the control of lipids in cell membranes.

Sterol Regulatory Element-Binding Proteins Induce an Entire Pathway of Cholesterol Synthesis

2001 ◽  
Vol 286 (1) ◽  
pp. 176-183 ◽  
Author(s):  
Yuki Sakakura ◽  
Hitoshi Shimano ◽  
Hirohito Sone ◽  
Akimitsu Takahashi ◽  
Kuniyuki Inoue ◽  
...  
Keyword(s):  
Cholesterol Synthesis ◽  
Binding Proteins ◽  
Regulatory Element ◽  
Sterol Regulatory Element
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