Neuroprotective Effect of Protein Kinase Cδ Inhibitor Rottlerin in Cell Culture and Animal Models of Parkinson's Disease

2007 ◽  
Vol 322 (3) ◽  
pp. 913-922 ◽  
Author(s):  
Danhui Zhang ◽  
Vellareddy Anantharam ◽  
Arthi Kanthasamy ◽  
Anumantha G. Kanthasamy
Keyword(s):  
Parkinson’S Disease ◽  
Cell Culture ◽  
Parkinson's Disease ◽  
Protein Kinase ◽  
Animal Models ◽  
Neuroprotective Effect ◽  
Protein Kinase Cδ

scholarly journals Dopaminergic neurotoxicant 6-OHDA induces oxidative damage through proteolytic activation of PKCδ in cell culture and animal models of Parkinson's disease

2011 ◽  
Vol 256 (3) ◽  
pp. 314-323 ◽  
Author(s):  
Calivarathan Latchoumycandane ◽  
Vellareddy Anantharam ◽  
Huajun Jin ◽  
Anumantha Kanthasamy ◽  
Arthi Kanthasamy
Keyword(s):  
Parkinson’S Disease ◽  
Cell Culture ◽  
Parkinson's Disease ◽  
Animal Models ◽  
Oxidative Damage ◽  
Proteolytic Activation

scholarly journals Fyn kinase regulates microglial neuroinflammatory responses in cell culture and animal models of Parkinson’s disease (1055.7)

2014 ◽  
Vol 28 (S1) ◽  
Author(s):  
Nikhil Panicker ◽  
Huajun Jin ◽  
Hariharan Saminathan ◽  
Kavin Kanthasamy ◽  
Vellareddy Anantram ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Cell Culture ◽  
Parkinson's Disease ◽  
Animal Models ◽  
Fyn Kinase

scholarly journals Parkinson's Disease and Systemic Inflammation

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Carina C. Ferrari ◽  
Rodolfo Tarelli
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Models ◽  
Neuroprotective Effect ◽  
Peripheral Inflammation ◽  
Peripheral Stimulus ◽  
Inflammatory Processes ◽  
Immune Challenges ◽  
General Response ◽  
The Brain

Peripheral inflammation triggers exacerbation in the central brain's ongoing damage in several neurodegenerative diseases. Systemic inflammatory stimulus induce a general response known as sickness behaviour, indicating that a peripheral stimulus can induce the synthesis of cytokines in the brain. In Parkinson's disease (PD), inflammation was mainly associated with microglia activation that can underlie the neurodegeneration of neurons in thesubstantia nigra(SN). Peripheral inflammation can transform the “primed” microglia into an “active” state, which can trigger stronger responses dealing with neurodegenerative processes. Numerous evidences show that systemic inflammatory processes exacerbate ongoing neurodegeneration in PD patient and animal models. Anti-inflammatory treatment in PD patients exerts a neuroprotective effect. In the present paper, we analyse the effect of peripheral infections in the etiology and progression in PD patients and animal models, suggesting that these peripheral immune challenges can exacerbate the symptoms in the disease.

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