Multimodal Biomarker Investigation on Efficacy and Mechanism of Action for the Mammalian Target of Rapamycin Inhibitor, Temsirolimus, in a Preclinical Mammary Carcinoma OncoMouse Model: A Translational Medicine Study in Support for Early Clinical Development

Clinical Development ◽

Target Of Rapamycin ◽

Early Clinical Development

Abstract 1745: Translational medicine enables rapid early clinical development of AVL-292, a highly selective, orally available inhibitor of Bruton's tyrosine kinase, in a phase 1b clinical trial

10.1158/1538-7445.am2012-1745 ◽

2012 ◽

Cited By ~ 1

Author(s):

William F. Westlin ◽

Kathryn Stiede ◽

Heather Lounsbury ◽

Steve Witowski ◽

Bruce Silver ◽

...

Keyword(s):

Clinical Trial ◽

Tyrosine Kinase ◽

Translational Medicine ◽

Clinical Development ◽

Bruton’S Tyrosine Kinase ◽

Bruton's Tyrosine Kinase ◽

Phase 1B ◽

Early Clinical Development

Clinical development of mammalian target of rapamycin inhibitors

Hematology/Oncology Clinics of North America ◽

10.1016/s0889-8588(02)00051-5 ◽

2002 ◽

Vol 16 (5) ◽

pp. 1101-1114 ◽

Cited By ~ 55

Author(s):

Janet E Dancey

Keyword(s):

Clinical Development ◽

Inhibitors of mammalian target of rapamycin: mechanism of action explains efficacy and toxicity

Current Opinion in Organ Transplantation ◽

10.1097/01.mot.0000146725.34815.ea ◽

2004 ◽

Vol 9 (4) ◽

pp. 369-382 ◽

Cited By ~ 1

Author(s):

Wojciech Lisik ◽

Barry D Kahan

Keyword(s):

Mechanism Of Action ◽

Faculty Opinions recommendation of Antagonistic roles for CTLA-4 and the mammalian target of rapamycin in the regulation of clonal anergy: enhanced cell cycle progression promotes recall antigen responsiveness.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1002644.29305 ◽

2001 ◽

Author(s):

Ron Schwartz

Keyword(s):

Cell Cycle ◽

Cell Cycle Progression ◽

Target Of Rapamycin ◽

Cycle Progression ◽

Recall Antigen ◽

Clonal Anergy

Faculty Opinions recommendation of Multiple site acetylation of Rictor stimulates mammalian target of rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.13420972.15108061 ◽

2012 ◽

Author(s):

Rony Seger ◽

Zhong Yao

Keyword(s):

Target Of Rapamycin ◽

Multiple Site

Faculty Opinions recommendation of The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.14253971.15768075 ◽

2012 ◽

Author(s):

Joseph Avruch ◽

Angela Papageorgiou

Keyword(s):

Gene Expression ◽

Transcriptional Profile ◽

Target Of Rapamycin ◽

Biosynthetic Gene ◽

Biosynthetic Gene Expression

Faculty Opinions recommendation of Loss of the repressor REST in uterine fibroids promotes aberrant G protein-coupled receptor 10 expression and activates mammalian target of rapamycin pathway.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717976173.793470470 ◽

2013 ◽

Author(s):

Phyllis Leppert

Keyword(s):

G Protein ◽

Uterine Fibroids ◽

Target Of Rapamycin ◽

G Protein Coupled Receptor ◽

G Protein Coupled

Faculty Opinions recommendation of Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717977210.793470744 ◽

2013 ◽

Author(s):

Matt Kaeberlein

Keyword(s):

Target Of Rapamycin ◽

Cognitive Components ◽

Components Of Behavior

Faculty Opinions recommendation of Response of lymphangioleiomyomatosis to a mammalian target of rapamycin inhibitor (temsirolimus) -based treatment.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725237527.793501496 ◽

2014 ◽

Author(s):

Angelo Taveira-DaSilva

Keyword(s):

Expression of phosphorylated mammalian target of rapamycin in colorectal cancer and its significance

Academic Journal of Second Military Medical University ◽

10.3724/sp.j.1008.2009.00517 ◽

2009 ◽

Vol 29 (5) ◽

pp. 517-520

Author(s):

Hong-gang XIANG ◽

Zhi-qian HU ◽

Wei-jun WANG ◽

Jian XU ◽

Jian ZHANG ◽

...

Keyword(s):

Colorectal Cancer ◽