scholarly journals Targeted Drug Delivery to Hepatic Stellate Cells for the Treatment of Liver Fibrosis

2019 ◽  
Vol 370 (3) ◽  
pp. 695-702 ◽  
Author(s):  
Zhijin Chen ◽  
Akshay Jain ◽  
Hao Liu ◽  
Zhen Zhao ◽  
Kun Cheng
Keyword(s):  
Drug Delivery ◽  
Liver Fibrosis ◽  
Hepatic Stellate Cells ◽  
Targeted Drug Delivery ◽  
Stellate Cells ◽  
Targeted Drug

scholarly journals Nanotechnology in Drug Delivery for Liver Fibrosis

2022 ◽  
Vol 8 ◽  
Author(s):  
Lihong Gu ◽  
Feng Zhang ◽  
Jinhui Wu ◽  
Yuzheng Zhuge
Keyword(s):  
Drug Delivery ◽  
Liver Cirrhosis ◽  
Side Effects ◽  
Liver Fibrosis ◽  
Liver Injury ◽  
Liver Cancer ◽  
Targeted Drug Delivery ◽  
Development Work ◽  
Disease Course ◽  
Targeted Drug

Liver fibrosis is a reversible disease course caused by various liver injury etiologies, and it can lead to severe complications, such as liver cirrhosis, liver failure, and even liver cancer. Traditional pharmacotherapy has several limitations, such as inadequate therapeutic effect and side effects. Nanotechnology in drug delivery for liver fibrosis has exhibited great potential. Nanomedicine improves the internalization and penetration, which facilitates targeted drug delivery, combination therapy, and theranostics. Here, we focus on new targets and new mechanisms in liver fibrosis, as well as recent designs and development work of nanotechnology in delivery systems for liver fibrosis treatment.

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