scholarly journals Nanotechnology in Drug Delivery for Liver Fibrosis

2022 ◽  
Vol 8 ◽  
Author(s):  
Lihong Gu ◽  
Feng Zhang ◽  
Jinhui Wu ◽  
Yuzheng Zhuge
Keyword(s):  
Drug Delivery ◽  
Liver Cirrhosis ◽  
Side Effects ◽  
Liver Fibrosis ◽  
Liver Injury ◽  
Liver Cancer ◽  
Targeted Drug Delivery ◽  
Development Work ◽  
Disease Course ◽  
Targeted Drug

Liver fibrosis is a reversible disease course caused by various liver injury etiologies, and it can lead to severe complications, such as liver cirrhosis, liver failure, and even liver cancer. Traditional pharmacotherapy has several limitations, such as inadequate therapeutic effect and side effects. Nanotechnology in drug delivery for liver fibrosis has exhibited great potential. Nanomedicine improves the internalization and penetration, which facilitates targeted drug delivery, combination therapy, and theranostics. Here, we focus on new targets and new mechanisms in liver fibrosis, as well as recent designs and development work of nanotechnology in delivery systems for liver fibrosis treatment.

In vitro study of doxorubicin-loaded thermo- and pH-tunable carriers for targeted drug delivery to liver cancer cells

2021 ◽  
Vol 104 ◽  
pp. 93-105
Author(s):  
Sikhumbuzo Charles Kunene ◽  
Kuen-Song Lin ◽  
Meng-Tzu Weng ◽  
Maria Janina Carrera Espinoza ◽  
Chun-Ming Wu
Keyword(s):  
Drug Delivery ◽  
Liver Cancer ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
In Vitro Study ◽  
Vitro Study ◽  
Liver Cancer Cells ◽  
Targeted Drug

scholarly journals A Prototype Therapeutic Capsule Endoscope for Ultrasound-Mediated Targeted Drug Delivery

2018 ◽  
Vol 03 (02) ◽  
pp. 1840001 ◽  
Author(s):  
Fraser Stewart ◽  
Antonella Verbeni ◽  
Yongqiang Qiu ◽  
Ben F. Cox ◽  
Jan Vorstius ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Crohn’S Disease ◽  
Side Effects ◽  
Capsule Endoscopy ◽  
Targeted Drug Delivery ◽  
Capsule Endoscope ◽  
Proof Of Concept ◽  
Gi Tract ◽  
Preliminary Results ◽  
Targeted Drug

The prevalence of gastrointestinal (GI) diseases such as Crohn’s disease, which is chronic and incurable, are increasing worldwide. Treatment often involves potent drugs with unwanted side effects. The technological–pharmacological combination of capsule endoscopy with ultrasound-mediated targeted drug delivery (UmTDD) described in this paper carries new potential for treatment of these diseases throughout the GI tract. We describe a proof-of-concept UmTDD capsule and present preliminary results to demonstrate its promise as an autonomous tool to treat GI diseases.

scholarly journals Traditional, unfairly forgotten, rarely used and promising drug delivery methods in ophthalmology: a clinical interpretation (part 1)

2019 ◽  
Vol 12 (2) ◽  
pp. 83-95 ◽  
Author(s):  
A. V. Kuroyedov ◽  
V. V. Brzhesky ◽  
E. A. Krinitsyna
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Drug Concentration ◽  
Targeted Drug Delivery ◽  
Anatomical Structure ◽  
Delivery Methods ◽  
Clinical Interpretation ◽  
Physiological Properties ◽  
Challenging Tasks ◽  
Targeted Drug

Ocular targeted drug delivery is one of the most challenging tasks for pharmaceutical researchers and practical ophthalmologists. The possibilities of drug delivery to the eye are naturally determined by the anatomical structure of the eye and its physiological properties, which restrict the period when therapeutically required drug concentration could be maintained. Combined drug delivery schemes may, potentially, improve the patient’s acceptance of treatment, reduce side effects, increase efficacy, and eventually preserve vision.

Approaches for Targeted Drug Delivery to Colon

2010 ◽  
Vol 3 (1) ◽  
Author(s):  
Shyam Prasad ◽  
Vidhu Aeri ◽  
Yashwant .
Keyword(s):  
Drug Delivery ◽  
Drug Interaction ◽  
Gastrointestinal Tract ◽  
Side Effects ◽  
Drug Delivery System ◽  
Targeted Drug Delivery ◽  
Biological Membrane ◽  
Colonic Disease ◽  
Conventional Drug ◽  
Targeted Drug

The conventional drug delivery system for colonic disease may leads to absorption of drug across biological membrane of gastrointestinal tract (GIT). The absorption of drug throughout GIT may leads to increase in dose and associated side effects. Colon targeted drug delivery (CTDD) is a method of delivering medication to a patient in a manner that increases concentration of the medication in colon relative to other part of GIT. The aim of CTDD is to prolong, localize, target and have protected drug interaction to diseased tissue. The present review deals with primary as well as recent approaches of delivery of drug to colon.

Investigating drug delivery of 5-fluorouracil by assistance of an iron-modified graphene scaffold: Computational studies

2021 ◽  
pp. 1-8
Author(s):  
Mohammad Hasan Kamel Attar Kar ◽  
Mohammad Yousefi
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Targeted Drug Delivery ◽  
Molecular Orbitals ◽  
Computational Studies ◽  
Final Remark ◽  
Anti Cancer ◽  
Computational Work ◽  
Targeted Drug ◽  
Modified Graphene

This computational work was performed to investigate drug delivery of 5-fluorouracil (FU) anti-cancer by assistance of an iron(Fe)-modified graphene (G) scaffold. The models were optimized to reach the minimized energy structures in both of singular and bimolecular models. Two models of FU@G complex were obtained including O2@G and O4@G by relaxation of FU through O2 and O4 atoms towards the Fe-atom region of G surface. The obtained results of energies indicated a higher stability and strength for the O2@G model in comparison with the O4@G model. The quantitative and qualitative features of electronic molecular orbitals indicated the investigated G surface could work as a carrier of FU by reducing the unwanted side effects and also playing the sensor role. As a final remark of this work, the investigated G model could be proposed for employing in the targeted drug delivery of FU in both of carrier and sensor agents.

scholarly journals MAGNETIC MICROSPHERE AN EMERGING DRUG DELIVERY SYSTEM

2017 ◽  
Vol 10 (6) ◽  
pp. 54 ◽  
Author(s):  
Diksha Sharma ◽  
Abhishek Sharma
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
The Body ◽  
Magnetic Microspheres ◽  
Magnetic Microsphere ◽  
Targeted Drug ◽  
Novel Drug

  The drug delivery system has been advanced to release the drug according to the body requirement during the entire period of treatment and also for the delivery at the targeted site. Several novel drug delivery systems have emerged encompassing different route of administration to achieve controlled and targeted drug delivery, magnetic microsphere carrier being one of them. Magnetic microsphere is an alternative to traditional radiation methods. As the traditional radiation methods use highly penetrating radiation that is absorbed throughout the body and cause side effects hence its use is limited. Therefore, a safe and effective alternate is needed like magnetic microsphere. The excessive circulating drug particles are minimized by this delivery system. Moreover, the aim of specific targeting is to enhance the effectiveness of drug delivery and at the same time to lessen the toxicity and side effects. Magnetic carriers receive magnetic responses to a magnetic field from incorporated materials that are used for magnetic microsphere are chitosan, dextran, etc. One of the most utilized magnetic microspheres is serum albumine whether from human or other suitable animals. Drug release from the albumin microsphere can be controlled by various stabilization procedures. Overall, the targeted magnetic microsphere is much valuable novel drug delivery system for what more work have to be done. By knowing the importance of all this, the present paper reviews the mechanism, preparation, and applications of magnetic microspheres. As the targeted drug delivery system implies selective and effective localization of drug into the target at therapeutic concentrations with limited access to non-target sites. Magnetic microspheres hold great promises for reaching the goal of controlled and site-specific drug delivery.

Paclitaxel-loaded poly(γ-glutamic acid)-poly(lactide) nanoparticles as a targeted drug delivery system for the treatment of liver cancer

Biomaterials ◽  
2006 ◽  
Vol 27 (9) ◽  
pp. 2051-2059 ◽  
Author(s):  
Hsiang-Fa Liang ◽  
Chiung-Tong Chen ◽  
Sung-Ching Chen ◽  
Anandrao R. Kulkarni ◽  
Ya-Ling Chiu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Liver Cancer ◽  
Glutamic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Targeted Drug ◽  
Targeted Drug Delivery System
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