K252a Prevents Nigral Dopaminergic Cell Death Induced by 6-Hydroxydopamine through Inhibition of Both Mixed-Lineage Kinase 3/c-Jun NH2-Terminal Kinase 3 (JNK3) and Apoptosis-Inducing Kinase 1/JNK3 Signaling Pathways

2007 ◽  
Vol 72 (6) ◽  
pp. 1607-1618 ◽  
Author(s):  
Jing Pan ◽  
Gang Wang ◽  
Hong-Qi Yang ◽  
Zhen Hong ◽  
Qin Xiao ◽  
...  
Keyword(s):  
Cell Death ◽  
Signaling Pathways ◽  
Dopaminergic Cell ◽  
Mixed Lineage Kinase ◽  
6 Hydroxydopamine ◽  
Mixed Lineage Kinase 3

scholarly journals Mixed lineage kinase 3 negatively regulates IKK activity and enhances etoposide-induced cell death

2009 ◽  
Vol 1793 (12) ◽  
pp. 1811-1818 ◽  
Author(s):  
Eric T. Cole ◽  
Yu Zhan ◽  
Widian F. Abi Saab ◽  
Amanda C. Korchnak ◽  
Brian P. Ashburner ◽  
...  
Keyword(s):  
Cell Death ◽  
Mixed Lineage Kinase ◽  
Mixed Lineage Kinase 3

scholarly journals Intracellular signaling pathways involved in post-mitotic dopaminergic PC12 cell death induced by 6-hydroxydopamine

2008 ◽  
Vol 107 (1) ◽  
pp. 127-140 ◽  
Author(s):  
Jezabel Rodriguez-Blanco ◽  
Vanesa Martín ◽  
Federico Herrera ◽  
Guillermo García-Santos ◽  
Isaac Antolín ◽  
...  
Keyword(s):  
Cell Death ◽  
Signaling Pathways ◽  
Pc12 Cell ◽  
Intracellular Signaling ◽  
Intracellular Signaling Pathways ◽  
6 Hydroxydopamine

scholarly journals Lysine 63-linked Ubiquitination Modulates Mixed Lineage Kinase-3 Interaction with JIP1 Scaffold Protein in Cytokine-induced Pancreatic β Cell Death

2012 ◽  
Vol 288 (4) ◽  
pp. 2428-2440 ◽  
Author(s):  
Rohan K. Humphrey ◽  
Shu Mei A. Yu ◽  
Aditi Bellary ◽  
Sumati Gonuguntla ◽  
Myra Yebra ◽  
...  
Keyword(s):  
Cell Death ◽  
Scaffold Protein ◽  
Pancreatic Β Cell ◽  
Β Cell ◽  
Mixed Lineage Kinase ◽  
Mixed Lineage Kinase 3

scholarly journals Erythropoietin protects against 6-hydroxydopamine-induced dopaminergic cell death

2006 ◽  
Vol 96 (2) ◽  
pp. 428-443 ◽  
Author(s):  
Armando P. Signore ◽  
Zhongfang Weng ◽  
Teresa Hastings ◽  
Amber D. Van Laar ◽  
Qinghua Liang ◽  
...  
Keyword(s):  
Cell Death ◽  
Dopaminergic Cell ◽  
6 Hydroxydopamine

Involvement of mixed lineage kinase 3 in cancer

2013 ◽  
Vol 91 (4) ◽  
pp. 268-274 ◽  
Author(s):  
Deborah N. Chadee
Keyword(s):  
Signaling Pathways ◽  
Cellular Responses ◽  
Mapk Signaling ◽  
Mitogen Activated Protein Kinase ◽  
Migration And Invasion ◽  
Cancer Treatments ◽  
Mixed Lineage Kinase ◽  
Mitogen Activated Protein ◽  
Mixed Lineage Kinase 3 ◽  
Mapk Signaling Pathways

Mitogen-activated protein kinase (MAPK) signaling pathways are composed of a phosphorelay signaling module where an activated MAP kinase kinase kinase (MAP3K) phosphorylates and activates a MAPK kinase (MAP2K) that in turn phosphorylates and activates a MAPK. The biological outcome of MAPK signaling is the regulation of cellular responses such as proliferation, differentiation, migration, and apoptosis. The MAP3K mixed lineage kinase 3 (MLK3) phosphorylates MAP2Ks to activate multiple MAPK signaling pathways, and MLK3 also has functions in cell signaling that are independent of its kinase activity. The recent elucidation of essential functions for MLK3 in tumour cell proliferation, migration, and invasion has drawn attention to the MLKs as potential therapeutic targets for cancer treatments. The mounting evidence that suggests a role for MLK3 in tumourigenesis and establishment of the malignant phenotype is the focus of this review.

scholarly journals Glycogen Synthase Kinase-3β Induces Neuronal Cell Death via Direct Phosphorylation of Mixed Lineage Kinase 3

2007 ◽  
Vol 282 (42) ◽  
pp. 30393-30405 ◽  
Author(s):  
Rajakishore Mishra ◽  
Manoj K. Barthwal ◽  
Gautam Sondarva ◽  
Basabi Rana ◽  
Lucas Wong ◽  
...  
Keyword(s):  
Cell Death ◽  
Glycogen Synthase ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Glycogen Synthase Kinase ◽  
Glycogen Synthase Kinase 3Β ◽  
Mixed Lineage Kinase ◽  
Mixed Lineage Kinase 3
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