Combined Targeting of Epidermal Growth Factor Receptor, Signal Transducer and Activator of Transcription-3, and Bcl-XL Enhances Antitumor Effects in Squamous Cell Carcinoma of the Head and Neck

Amanda L. Boehm; Malabika Sen; Raja Seethala; William E. Gooding; Maria Freilino; Silvia Man Yan Wong; Shaomeng Wang; Daniel E. Johnson; Jennifer Rubin Grandis

doi:10.1124/mol.107.044636

Combined Targeting of Epidermal Growth Factor Receptor, Signal Transducer and Activator of Transcription-3, and Bcl-XL Enhances Antitumor Effects in Squamous Cell Carcinoma of the Head and Neck

Molecular Pharmacology ◽

10.1124/mol.107.044636 ◽

2008 ◽

Vol 73 (6) ◽

pp. 1632-1642 ◽

Cited By ~ 53

Author(s):

Amanda L. Boehm ◽

Malabika Sen ◽

Raja Seethala ◽

William E. Gooding ◽

Maria Freilino ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Signal Transducer ◽

Antitumor Effects ◽

Receptor Signal ◽

Epidermal Growth ◽

Transcription 3

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Intercellular contact augments epidermal growth factor receptor (EGFR) and signal transducer and activator of transcription 3 (STAT3)-activation which increases podoplanin-expression in order to promote squamous cell carcinoma motility

Cellular Signalling ◽

10.1016/j.cellsig.2012.12.004 ◽

2013 ◽

Vol 25 (4) ◽

pp. 760-765 ◽

Cited By ~ 8

Author(s):

Mizue Fujii ◽

Masaru Honma ◽

Hidetoshi Takahashi ◽

Akemi Ishida-Yamamoto ◽

Hajime Iizuka

Keyword(s):

Squamous Cell Carcinoma ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Intercellular Contact ◽

Signal Transducer ◽

Podoplanin Expression ◽

Epidermal Growth ◽

Transcription 3

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SCH66336, inhibitor of protein farnesylation, blocks signal transducer and activators of transcription 3 signaling in lung cancer and interacts with a small molecule inhibitor of epidermal growth factor receptor/human epidermal growth factor receptor 2

Anti-Cancer Drugs ◽

10.1097/cad.0b013e3282f1a908 ◽

2008 ◽

Vol 19 (1) ◽

pp. 9-16 ◽

Cited By ~ 12

Author(s):

Afshin Dowlati ◽

Amy Kluge ◽

David Nethery ◽

Balazs Halmos ◽

Jeffrey A. Kern

Keyword(s):

Lung Cancer ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Small Molecule ◽

Growth Factor Receptor ◽

Signal Transducer ◽

Molecule Inhibitor ◽

Epidermal Growth ◽

Transcription 3

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Alpha-1 adrenergic receptor transactivates signal transducer and activator of transcription-3 (Stat3) through activation of Src and epidermal growth factor receptor (EGFR) in hepatocytes

Journal of Cellular Physiology ◽

10.1002/jcp.21420 ◽

2008 ◽

Vol 216 (2) ◽

pp. 486-497 ◽

Cited By ~ 24

Author(s):

Chang Han ◽

William C. Bowen ◽

George K. Michalopoulos ◽

Tong Wu

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Adrenergic Receptor ◽

Growth Factor Receptor ◽

Signal Transducer ◽

Epidermal Growth ◽

Transcription 3

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Epidermal Growth Factor Receptor Cooperates with Signal Transducer and Activator of Transcription 3 to Induce Epithelial-Mesenchymal Transition in Cancer Cells via Up-regulation of TWIST Gene Expression

Cancer Research ◽

10.1158/0008-5472.can-07-0575 ◽

2007 ◽

Vol 67 (19) ◽

pp. 9066-9076 ◽

Cited By ~ 430

Author(s):

Hui-Wen Lo ◽

Sheng-Chieh Hsu ◽

Weiya Xia ◽

Xinyu Cao ◽

Jin-Yuan Shih ◽

...

Keyword(s):

Gene Expression ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Epithelial Mesenchymal Transition ◽

Growth Factor Receptor ◽

Signal Transducer ◽

Mesenchymal Transition ◽

Epidermal Growth ◽

Transcription 3

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Signal Transducer and Activator of Transcription 3 Is Required for the Oncogenic Effects of Non–Small-Cell Lung Cancer–Associated Mutations of the Epidermal Growth Factor Receptor

Cancer Research ◽

10.1158/0008-5472.can-05-3757 ◽

2006 ◽

Vol 66 (6) ◽

pp. 3162-3168 ◽

Cited By ~ 160

Author(s):

James V. Alvarez ◽

Heidi Greulich ◽

William R. Sellers ◽

Matthew Meyerson ◽

David A. Frank

Keyword(s):

Lung Cancer ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Small Cell ◽

Signal Transducer ◽

Small Cell Lung ◽

Epidermal Growth ◽

Transcription 3

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Immunohistochemical Analysis of Phosphotyrosine Signal Transducer and Activator of Transcription 3 and Epidermal Growth Factor Receptor Autocrine Signaling Pathways in Head and Neck Cancers and Metastatic Lymph Nodes

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-07-1543 ◽

2008 ◽

Vol 14 (5) ◽

pp. 1303-1309 ◽

Cited By ~ 32

Author(s):

Raja R. Seethala ◽

William E. Gooding ◽

Phoebe N. Handler ◽

Bobby Collins ◽

Qing Zhang ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Lymph Nodes ◽

Growth Factor Receptor ◽

Immunohistochemical Analysis ◽

Signal Transducer ◽

Autocrine Signaling ◽

Epidermal Growth ◽

Transcription 3

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Enhanced Sensitivity of Pancreatic Cancer Cells to Concurrent Inhibition of Aberrant Signal Transducer and Activator of Transcription 3 and Epidermal Growth Factor Receptor or Src

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.109.162669 ◽

2010 ◽

Vol 333 (2) ◽

pp. 373-381 ◽

Cited By ~ 24

Author(s):

Soumya Jaganathan ◽

Peibin Yue ◽

James Turkson

Keyword(s):

Pancreatic Cancer ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Signal Transducer ◽

Enhanced Sensitivity ◽

Pancreatic Cancer Cells ◽

Epidermal Growth ◽

Transcription 3

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Prognostic Significance of Epidermal Growth Factor Receptor Phosphorylation and Mutation in Head and Neck Squamous Cell Carcinoma

The Oncologist ◽

10.1634/theoncologist.2009-0058erratum ◽

2009 ◽

Vol 14 (10) ◽

pp. 1050-1050 ◽

Cited By ~ 1

Author(s):

Takanori Hama ◽

Yuki Yuza ◽

Yoshimichi Saito ◽

Jin O‐uchi ◽

Shu Kondo ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Prognostic Significance ◽

Growth Factor Receptor ◽

Epidermal Growth

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Human Papillomavirus, p16, and Epidermal Growth Factor Receptor Biomarkers and CT Perfusion Values in Head and Neck Squamous Cell Carcinoma

American Journal of Neuroradiology ◽

10.3174/ajnr.a3349 ◽

2013 ◽

Vol 34 (5) ◽

pp. 1062-1066 ◽

Cited By ~ 7

Author(s):

N.L. Hoefling ◽

J.B. McHugh ◽

E. Light ◽

B. Kumar ◽

H. Walline ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Epidermal Growth Factor Receptor ◽

Human Papillomavirus ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Cell Carcinoma ◽

Head And Neck ◽

Ct Perfusion ◽

Growth Factor Receptor ◽

Epidermal Growth

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Survey of the use of tests for human papilloma virus and epidermal growth factor receptor for squamous cell carcinoma of the head and neck in UK head and neck multidisciplinary teams

British Journal of Oral and Maxillofacial Surgery ◽

10.1016/j.bjoms.2011.02.002 ◽

2012 ◽

Vol 50 (2) ◽

pp. 119-121 ◽

Cited By ~ 3

Author(s):

Abdul Ahmed ◽

Luke Cascarini ◽

Ann Sandison ◽

Peter Clarke

Keyword(s):

Squamous Cell Carcinoma ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Human Papilloma Virus ◽

Head And Neck ◽

Growth Factor Receptor ◽

Multidisciplinary Teams ◽

Papilloma Virus ◽

Epidermal Growth

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